Gut microbial metabolism in Alzheimer's disease and related dementias

Neurotherapeutics, Journal Year: 2024, Volume and Issue: 21(6), P. e00470 - e00470

Published: Oct. 1, 2024

Multiple studies over the last decade have established that Alzheimer's disease and related dementias (ADRD) are associated with changes in gut microbiome. These alterations organismal composition result abundances of functions encoded by microbial community, including metabolic capabilities, which likely impact host mechanisms. Gut microbes access dietary components other molecules made produce metabolites can enter circulation cross blood-brain barrier (BBB). In recent years, several been or shown to influence pathways relevant ADRD pathology. include short chain fatty acids, secondary bile tryptophan derivatives (such as kynurenine, serotonin, tryptamine, indoles), trimethylamine/trimethylamine N-oxide. Notably, some these BBB various effects on brain, modulating release neurotransmitters neuronal function, inducing oxidative stress inflammation, impacting synaptic function. Microbial also central nervous system through immune, enteroendocrine, enteric pathways, perturbations turn function peripheral immune responses, well integrity, homeostasis neurogenesis, glial cell maturation activation. This review examines evidence supporting notion is influenced microbiota its metabolites. The potential therapeutic advantages for preventing treating discussed, highlighting their role developing new treatments.

Language: Английский

---

Untargeted urine metabolomics reveals dynamic metabolic differences and key biomarkers across different stages of Alzheimer’s disease

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: Jan. 27, 2025

Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, with mild cognitive impairment (MCI) often serving as its precursor stage. Early intervention at the MCI stage can significantly delay AD onset. Methods This study employed untargeted urine metabolomics, data obtained from MetaboLights database (MTBLS8662), combined orthogonal partial least squares-discriminant analysis (OPLS-DA) to examine metabolic differences across different stages of progression. A decision tree approach was used identify key metabolites within enriched pathways. These were then utilized construct and validate an progression prediction model. Results The OPLS-DA model effectively distinguished characteristics stages. Pathway enrichment revealed that Drug metabolism all stages, while Retinol particularly prominent during transition Key such Theophylline, Vanillylmandelic Acid (VMA), Adenosine showed significant differencesdifferencesin early disease, whereas 1,7-Dimethyluric Acid, Cystathionine, Indole exhibited strong predictive value transition. play crucial role in monitoring Predictive models based on these demonstrated excellent classification capabilities. Conclusion systematically analyzed dynamic identified pathways potential biomarkers for intervention. Utilizing urinary findings provide theoretical basis contribute improving prevention strategies, thereby potentially delaying

Language: Английский

---

Ketogenic diet, adenosine, and dopamine in addiction and psychiatry

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 10, 2025

Adhering to the ketogenic diet can reduce or stop seizures, even when other treatments fail, via mechanism(s) distinct from available therapies. These results have led interest in for treating conditions such as Alzheimer’s disease, depression and schizophrenia. Evidence points neuromodulator adenosine a key mechanism underlying therapeutic benefits of diet. Adenosine represents unique direct link among cell energy, neuronal activity, gene expression, receptors form functional heteromers with dopamine receptors. The importance dopaminergic system is established addiction, are challenges modulating directly. A mediator that could antagonize dopamine’s effects would be useful, due its function location. Studies report improves cognition, sociability, perseverative behaviors, might improve depression. Many translational opportunities based on diet/adenosine come fore, including autism spectrum disorder, painful conditions, range hyperdopaminergic disorders.

Language: Английский

---

From Gut to Brain: The Role of Gut Dysbiosis, Bacterial Amyloids, and Metabolic Disease in Alzheimer’s Disease

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107693 - 107693

Published: March 1, 2025

Gut microbial dysbiosis, or altered gut communities, in Alzheimer's Disease suggests a pathogenic role for inflammation and products shaping neuroinflammatory environment. Similarly, metabolic diseases, such as obesity diabetes, are also associated with an increased risk of Disease. As the landscape shifts during inflammation, turn impacts processes, we explore how these interconnected pathways may contribute to progression Additionally, discuss bacterial amyloids produced by microbes, which exacerbate amyloid aggregation brain neurodegenerative processes. Furthermore, highlight potential therapeutic strategies aimed at reducing improving health, decreasing content means mitigate progression. These approaches, targeting gut-brain-metabolic axis, could offer promising avenues delaying preventing cognitive decline affected individuals.

Language: Английский

---

The Blood-Cerebrospinal Fluid Barrier Dysfunction in Brain Disorders and Stroke: Why, How, What For?

NeuroMolecular Medicine, Journal Year: 2024, Volume and Issue: 26(1)

Published: Sept. 15, 2024

Language: Английский

---

Dietary protein intake interacts with weak handgrip strength and cognitive impairment

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 102(2), P. 359 - 369

Published: Oct. 29, 2024

Handgrip strength correlates with cognitive function, but how gender and dietary protein interact it is unclear.

Language: Английский

---