Oxidant-Based Cytotoxic Agents During Aging: From Disturbed Energy Metabolism to Chronic Inflammation and Disease Progression DOI Creative Commons

Jürgen Arnhold

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 547 - 547

Published: April 9, 2025

In humans, aging is an inevitable consequence of diminished growth processes after reaching maturity. The high order biomolecules in cells and tissues continuously disturbed by numerous physical chemical destructive impacts. Host-derived oxidant-based cytotoxic agents (reactive species, transition free metal ions, heme) contribute considerably to this damage. These are under the control immediately acting antagonizing principles, which important ensure cell tissue homeostasis. review, I apply concept host-derived their interplay with principles process. During aging, energy metabolism supply dioxygen nutrients increasingly disturbed. addition, a chronic inflammatory state develops, condition known as inflammaging. balance between protective mechanisms analyzed depending on age-based physiological alterations ATP production. Disturbances associated development age-related diseases comorbidities. An enhanced production reactive species from dysfunctional mitochondria, cellular redox homeostasis, adaptations hypoxia highlighted. Examples how disturbances pathogenesis persons advanced age given.

Language: Английский

Elucidating emerging signaling pathways driving endothelial dysfunction in cardiovascular aging DOI

Anna De Bartolo,

Tommaso Angelone, Carmine Rocca

et al.

Vascular Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 107462 - 107462

Published: Jan. 1, 2025

Language: Английский

Citations

1
What Is the Impact of Obesity-Related Comorbidities on the Risk of Premature Aging in Patients with Severe Obesity?: A Cross-Sectional Study DOI Creative Commons
Alicja Dudek, Barbara Zapała, Aleksandra Gorostowicz

et al.

Medicina, Journal Year: 2025, Volume and Issue: 61(2), P. 293 - 293

Published: Feb. 8, 2025

Background and Objectives: The relationships between aging, chronic diseases, obesity remain complex poorly understood. This study aimed to investigate the impact of comorbidities on premature aging in individuals with severe obesity. Materials Methods: cross-sectional included 99 bariatric patients (SG) 30 healthy volunteers (HC). SG was further divided into subgroups based comorbidity status. Various markers biological including interleukin-6 (IL-6), C-reactive protein (CRP), telomere length (TL), attention speed, executive functions, metabolic age, were evaluated. Results: Both presented elevated levels IL-6 CRP, shorter TLs, lower outcomes functioning tests, greater age than subjects. However, no significant differences observed without comorbidities. highlighted BMI increased inflammation revealed that hypertension are associated cognitive decline. Conclusions: These findings suggest obesity, regardless comorbidities, contributes aging. presence linked function decline, emphasizing multifaceted implications for process.

Language: Английский

Citations

0
Cell-specific role of apoptosis in the process of atherosclerosis DOI Creative Commons
Theofilos Kanavos, Effrosyni Birbas

Aging advances., Journal Year: 2025, Volume and Issue: 2(1), P. 21 - 28

Published: March 1, 2025

Atherosclerosis is a chronic disease of the arterial wall characterized by accumulation fatty and fibrous material in intima. It primary cause cardiovascular disease, which associated with high mortality morbidity rates, particularly aging populations. Apoptosis tightly regulated form programmed cell death that eliminates unneeded or harmful cells. Its role process atherosclerosis has been subject numerous recent studies. In this context, impact apoptosis on was comprehensively examined through narrative literature review. The effect depends types involved stage disease. Endothelial apoptosis, exacerbated aging, may disrupt integrity vascular lining thereby facilitate infiltration lipids into subendothelial space promote plaque vulnerability. Evidence suggests smooth muscle cells can inhibit their migration proliferation attenuate formation early but also induce instability thinning cap advanced stages Macrophage plays dual depending its timing as it limit lesion cellularity suppress progression initial while exacerbating necrotic core development vulnerability late stages. Although more studies are required to fully elucidate atherosclerosis, therapeutic manipulation appears be promising strategy for addressing multifactorial

Language: Английский

Citations

0
Oxidant-Based Cytotoxic Agents During Aging: From Disturbed Energy Metabolism to Chronic Inflammation and Disease Progression DOI Creative Commons

Jürgen Arnhold

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 547 - 547

Published: April 9, 2025

In humans, aging is an inevitable consequence of diminished growth processes after reaching maturity. The high order biomolecules in cells and tissues continuously disturbed by numerous physical chemical destructive impacts. Host-derived oxidant-based cytotoxic agents (reactive species, transition free metal ions, heme) contribute considerably to this damage. These are under the control immediately acting antagonizing principles, which important ensure cell tissue homeostasis. review, I apply concept host-derived their interplay with principles process. During aging, energy metabolism supply dioxygen nutrients increasingly disturbed. addition, a chronic inflammatory state develops, condition known as inflammaging. balance between protective mechanisms analyzed depending on age-based physiological alterations ATP production. Disturbances associated development age-related diseases comorbidities. An enhanced production reactive species from dysfunctional mitochondria, cellular redox homeostasis, adaptations hypoxia highlighted. Examples how disturbances pathogenesis persons advanced age given.

Language: Английский

Citations

0