The role of enriched environment in neural development and repair

Frontiers in Cellular Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: July 21, 2022

In addition to genetic information, environmental factors play an important role in the structure and function of nervous system occurrence development some diseases. Enriched environment (EE) can not only promote normal neural through enhancing neuroplasticity but also a nerve repair restoring functional activities during CNS injury by morphological cellular molecular adaptations brain. Different stages after birth respond varying degrees. Therefore, we systematically review pro-developmental anti-stress value EE pregnancy, pre-weaning, “adolescence” analyze difference effects its sub-components, especially with physical exercise. our exploration potential mechanisms that neurodevelopment, have found all sub-components exert maximum throughout developmental phase, such as animals do activity before weaning, is superior respects. affects developing adult brain, resulting neuroplastic changes microscopic macroscopic anatomy, finally contributing enhanced learning memory capacity. These positive promoting influences are particularly prominent regarding neurobiological disorders. Taking cerebral ischemia example, analyzed mediators from various dimensions. We does always lead on repair, infarct size. view classic issues standardization relativity been thoroughly discussed, focus analyzing essentiality time window action clinical translation order devote future research direction rapid reasonable application.

Language: Английский

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Tai Chi enhances cognitive training effects on delaying cognitive decline in mild cognitive impairment

Alzheimer s & Dementia, Journal Year: 2022, Volume and Issue: 19(1), P. 136 - 149

Published: March 15, 2022

Abstract Introduction Cognitive training and physical exercise have shown positive effects on delaying progression of mild cognitive impairment (MCI) to dementia. Methods We explored the enhancing effect from Tai Chi when it was provided with for MCI. In first 12 months, group (CT) had training, mixed (MixT) additional training. second only a subgroup MixT. Results MixT CT groups were benefited Compared group, reference baseline. addition, short‐time prolonged further delayed decline in global cognition memory. Functional magnetic resonance imaging showed more increased regional activity both Discussion enhanced Moreover, decline.

Language: Английский

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A Systematic Look at Environmental Modulation and Its Impact in Brain Development

Trends in Neurosciences, Journal Year: 2017, Volume and Issue: 41(1), P. 4 - 17

Published: Nov. 8, 2017

Language: Английский

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Can Healthy Diets, Regular Exercise, and Better Lifestyle Delay the Progression of Dementia in Elderly Individuals?

Journal of Alzheimer s Disease, Journal Year: 2019, Volume and Issue: 72(s1), P. S37 - S58

Published: June 18, 2019

Alzheimer's disease (AD) is a progressive neurodegenerative characterized by memory loss and multiple cognitive impairments. Current healthcare costs for over 50 million people afflicted with AD are about $818 projected to be $2 billion 2050. Unfortunately, there no drugs currently available that can delay and/or prevent the progression of in elderly individuals patients. Loss synapses synaptic damage largely correlated decline Women at higher lifetime risk developing encompassing two-thirds total population. Only 1-2% patients explained genetic mutations APP, PS1, PS2 genes. Several factors have been identified, such as Apolipoprotein E4 genotype, type 2 diabetes, traumatic brain injury, depression, hormonal imbalance, reported associated late-onset AD. Strong evidence reveals antioxidant enriched diets regular exercise reduces toxic radicals, enhances mitochondrial function activity, improves populations. data on use antioxidants mouse models antioxidant(s) supplements were investigated. The randomized clinical trials was also critically assessed. Based our survey current literature findings, we cautiously conclude healthy diets, exercise, improved lifestyle dementia reduce reverse subjects mild impairment non-demented state.

Language: Английский

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Cognitive and physical impact of cognitive-motor dual-task training in cognitively impaired older adults: An overview

Neurophysiologie Clinique, Journal Year: 2020, Volume and Issue: 50(6), P. 441 - 453

Published: Oct. 26, 2020

Language: Английский

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