Magnetic sensitivity of cryptochrome 4 from a migratory songbird

Nature, Journal Year: 2021, Volume and Issue: 594(7864), P. 535 - 540

Published: June 23, 2021

Language: Английский

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Quantum Biology: An Update and Perspective

Quantum Reports, Journal Year: 2021, Volume and Issue: 3(1), P. 80 - 126

Published: Jan. 26, 2021

Understanding the rules of life is one most important scientific endeavours and has revolutionised both biology biotechnology. Remarkable advances in observation techniques allow us to investigate a broad range complex dynamic biological processes which living systems could exploit quantum behaviour enhance regulate functions. Recent evidence suggests that these non-trivial mechanical effects may play crucial role maintaining non-equilibrium state biomolecular systems. Quantum study such aspects In this review, we summarise latest progress biology, including areas enzyme-catalysed reactions, photosynthesis, spin-dependent DNA, fluorescent proteins, ion channels. Many results are expected be fundamental building blocks towards understanding life.

Language: Английский

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Magnetic field effects in biology from the perspective of the radical pair mechanism

Journal of The Royal Society Interface, Journal Year: 2022, Volume and Issue: 19(193)

Published: Aug. 1, 2022

Hundreds of studies have found that weak magnetic fields can significantly influence various biological systems. However, the underlying mechanisms behind these phenomena remain elusive. Remarkably, energies implicated in effects are much smaller than thermal energies. Here, we review observations, and suggest an explanation based on radical pair mechanism, which involves quantum dynamics electron nuclear spins transient molecules. While mechanism has been studied detail context avian magnetoreception, reviewed here show magnetosensitivity is widespread throughout biology. We field physiological functions, discussing static, hypomagnetic oscillating fields, as well isotope effects. then a potential unifying model for described effects, discuss plausible candidate molecules pairs. recent proposing provides explanations xenon anaesthesia lithium treatment hyperactivity, circadian clock, neurogenesis microtubule assembly. conclude by future lines investigation this exciting new area

Language: Английский

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Quantum life science: biological nano quantum sensors, quantum technology-based hyperpolarized MRI/NMR, quantum biology, and quantum biotechnology

Chemical Society Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The emerging field of quantum life science combines principles from physics and biology to study fundamental processes at the molecular level.

Language: Английский

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Photodriven quantum teleportation of an electron spin state in a covalent donor–acceptor–radical system

Nature Chemistry, Journal Year: 2019, Volume and Issue: 11(11), P. 981 - 986

Published: Sept. 23, 2019

Language: Английский

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Photogenerated Spin-Correlated Radical Pairs: From Photosynthetic Energy Transduction to Quantum Information Science

Journal of the American Chemical Society, Journal Year: 2021, Volume and Issue: 143(38), P. 15508 - 15529

Published: Sept. 17, 2021

More than a half century ago, the NMR spectra of diamagnetic products resulting from radical pair reactions were observed to have strongly enhanced absorptive and emissive resonances. At same time, photogenerated pairs discovered exhibit unusual electron paramagnetic resonance that also had such These non-Boltzmann, spin-polarized in both chemical systems as well photosynthetic reaction center proteins following photodriven charge separation. Subsequent studies these phenomena led variety donor-acceptor model provided broad understanding spin dynamics responsible for spectra. When distance between two radicals is restricted, observations result formation spin-correlated (SCRPs) which spin-spin exchange dipolar interactions unpaired spins play an important role dynamics. Early on, it was recognized SCRPs by ultrafast transfer are entangled created well-defined state. can serve qubit (SQPs), whose be manipulated study wide quantum intrinsic field information science. This Perspective highlights SQPs, gives examples possible manipulations using provides some thoughts on future directions.

Language: Английский

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No evidence for magnetic field effects on the behaviour of Drosophila

Nature, Journal Year: 2023, Volume and Issue: 620(7974), P. 595 - 599

Published: Aug. 9, 2023

Abstract Migratory songbirds have the remarkable ability to extract directional information from Earth’s magnetic field 1,2 . The exact mechanism of this light-dependent compass sense, however, is not fully understood. most promising hypothesis focuses on quantum spin dynamics transient radical pairs formed in cryptochrome proteins retina 3–5 Frustratingly, much supporting evidence for theory circumstantial, largely because extreme challenges posed by genetic modification wild birds. Drosophila has therefore been recruited as a model organism, and several influential reports cryptochrome-mediated effects fly behaviour widely interpreted support pair-based birds 6–23 Here we report results an extensive study testing 97,658 flies moving two-arm maze 10,960 performing spontaneous escape known negative geotaxis. Under meticulously controlled conditions with vast sample sizes, unable find magnetically sensitive Moreover, after reassessment statistical approaches sizes used studies that tried replicate, suggest many—if all—of original were false positives. Our findings cast considerable doubt existence sensing thus strongly night-migratory remain organism choice elucidating magnetoreception.

Language: Английский

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Introduction of magneto-fluorescence fluctuation microspectroscopy for investigating quantum effects in biology

Nature Photonics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Magnetic field effects on radical pairs in chemical systems are generally well understood and have been successfully investigated with various spectroscopic techniques. However, understanding their quantum nature biological is still its infancy, which due to the limitation of high-sensitivity instrumentation. Another reason for this lack complexity biochemical reactions minute magnetic field-induced changes pair (as low as or lower than a percent). The system design presented here new optical capture mechanical biology high signal-to-noise ratio. Our magneto-fluorescence fluctuation microspectroscopic approach has capability measuring 0.2% fluorescence signals near single-photon level avalanche diodes, demonstrated by 23 molecules. An additional detection form an EMCCD camera offers spatially resolved novel post hoc digital lock-in amplifier phase-sensitive detection. aforementioned attributes photochemical model systems. instrument uncovers importance photodegradation protein–flavin interactions via effects, will prove paramount when searching similar locales.

Language: Английский

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Magnetic sensitivity mediated by the Arabidopsis blue-light receptor cryptochrome occurs during flavin reoxidation in the dark

Planta, Journal Year: 2018, Volume and Issue: 249(2), P. 319 - 332

Published: Sept. 7, 2018

Arabidopsis cryptochrome mediates responses to magnetic fields that have been applied in the absence of light, consistent with flavin reoxidation as primary detection mechanism. Cryptochromes are highly conserved blue-light-absorbing flavoproteins which linked perception electromagnetic stimuli numerous organisms. These include sensing direction earth's field migratory birds and intensity insects plants. When exposed cryptochromes undergo reduction/reoxidation redox cycles leading biological activation generate radical pairs thought be basis for sensitivity. However, nature magnetically sensitive steps at they act during cycle currently a matter debate. Here, we investigate response cryptochrome-1 vivo static 500 μT (10 × field) using both plant growth light-dependent phosphorylation an assay. Cryptochrome light were enhanced by field, indicated increased inhibition hypocotyl elongation phosphorylation. when dark intervals given intermittently, was observed even exclusively between exposures. This indicates reaction step photocycle must occur reoxidation, likely involves formation reactive oxygen species.

Language: Английский

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Radical-Pair-Based Magnetoreception Amplified by Radical Scavenging: Resilience to Spin Relaxation

The Journal of Physical Chemistry B, Journal Year: 2017, Volume and Issue: 121(44), P. 10215 - 10227

Published: Oct. 13, 2017

Birds and several other species are equipped with the remarkable ability to sense geomagnetic field for purpose of navigation orientation. The primary detection mechanism this compass is uncertain but appears originate from a truly quantum process involving spin-correlated radical pairs. In order elicit sensitivity weak magnetic fields, such as Earth's field, underlying spin dynamics must be protected fast decoherence. work, we elucidate effects relaxation on recently suggested reaction scheme three radicals, instead pair, doublet-quartet interconversion under interactions, spin-selective scavenging reaction. We show that, besides giving rise vastly enhanced anisotropy, extended more resilient than conventional pair mechanism. Surprisingly, anisotropic effect can by in one radicals pair. discuss finding context magnetoreception. Radical protect system against thereby providing credible model involvement relaxing pairs, FADH•/O2•-, radical-pair based This will help explain behavioral observations that seem incompatible previously proposed flavin semiquinone/tryptophanyl

Language: Английский

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