Springer eBooks, Journal Year: 2019, Volume and Issue: unknown, P. 159 - 180
Published: Oct. 14, 2019
Language: Английский
Natural Product Reports, Journal Year: 2012, Volume and Issue: 29(3), P. 372 - 372
Published: Jan. 1, 2012
This review covers the literature on chemically mediated ecology of cyanobacteria, including ultraviolet radiation protection, feeding-deterrence, allelopathy, resource competition, and signalling. To highlight chemical biological diversity this group organisms, evolutionary chemotaxonomical studies are presented. Several technologically relevant aspects cyanobacterial also discussed.
Language: Английский
Citations
161
International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(3), P. 731 - 731
Published: Jan. 22, 2020
Marine biofilms are composed of many species bacteria, unicellular algae, and protozoa. Biofilms can induce, inhibit, or have no effect on settlement larvae spores algae. In this review, we focus induction larval by marine bacteria eukaryotes review publications from 2010 to September 2019. This provides insights meta-analysis what is known about the settlement. Of great interest impact different components biofilms, such as diatoms, extracellular polymeric substances, quorum sensing signals, unique inductive compounds, exoenzymes, structural protein degradation products metamorphosis. Molecular aspects climate change reviewed and, finally, potential areas future investigations provided.
Language: Английский
Citations
137
Nature Communications, Journal Year: 2018, Volume and Issue: 9(1)
Published: June 20, 2018
Microbial symbionts are often a source of chemical novelty and can contribute to host defense against antagonists. However, the ecological relevance mediators remains unclear for most systems. Lagria beetles live in symbiosis with multiple strains Burkholderia bacteria that protect their offspring pathogens. Here, we describe antifungal polyketide lagriamide, provide evidence supporting it is produced by an uncultured symbiont, gladioli Lv-StB, which dominant field-collected villosa. Interestingly, lagriamide structurally similar bistramides, defensive compounds found marine tunicates. We identify gene cluster probably involved biosynthesis, horizontal acquisition these genes, show naturally occurring symbiont on egg protective soil environment. Our findings highlight potential microbial transfer as influential sources innovation.
Language: Английский
Citations
116
Current Protocols in Pharmacology, Journal Year: 2019, Volume and Issue: 86(1)
Published: Aug. 26, 2019
Many natural products have been used as drugs for the treatment of diverse indications. Although most U.S. pharmaceutical companies reduced or eliminated their in-house natural-product research over years, new approaches compound screening and chemical synthesis are resurrecting interest in exploring therapeutic value products. The aim this commentary is to review emerging strategies techniques that made a viable strategic choice inclusion drug discovery programs. Published 2019. Government.
Language: Английский
Citations
114
Natural Product Reports, Journal Year: 2013, Volume and Issue: 30(11), P. 1380 - 1380
Published: Jan. 1, 2013
Coverage period: 1965 to 2012
Language: Английский
Citations
107
Marine Drugs, Journal Year: 2016, Volume and Issue: 14(5), P. 98 - 98
Published: May 21, 2016
Marine invertebrates provide a rich source of metabolites with anticancer activities and several marine-derived agents have been approved for the treatment cancer. However, limited supply promising from their natural sources is major hurdle to preclinical clinical development. Thus, lack sustainable large-scale has an important challenge facing chemists biologists involved in marine-based drug discovery. In current review we describe main strategies aimed overcome problem. These include: marine invertebrate aquaculture, symbiont cell culture, culture-independent strategies, total chemical synthesis, semi-synthesis, number hybrid strategies. We examples illustrating application these invertebrate-derived agents. Finally, encourage scientific community develop scalable methods obtain selected metabolites, which authors’ opinion should be pursued due most activities.
Language: Английский
Citations
88
Marine Drugs, Journal Year: 2019, Volume and Issue: 17(8), P. 468 - 468
Published: Aug. 11, 2019
Marine invertebrates and their associated microorganisms are rich sources of bioactive compounds. Among them, coral its promising providers marine The present review provides an overview compounds that produced by corals coral-associated microorganisms, covering the literature from 2010 to March 2019. Accordingly, 245 natural products possess a wide range potent bioactivities, such as anti-inflammatory, cytotoxic, antimicrobial, antivirus, antifouling activities, among others, described in this review.
Language: Английский
Citations
78
Marine Drugs, Journal Year: 2023, Volume and Issue: 21(3), P. 174 - 174
Published: March 9, 2023
Diverse ecologically important metabolites, such as allelochemicals, infochemicals and volatile organic chemicals, are involved in marine organismal interactions. Chemically mediated interactions between intra- interspecific organisms can have a significant impact on community organization, population structure ecosystem functioning. Advances analytical techniques, microscopy genomics providing insights the chemistry functional roles of metabolites This review highlights targeted translational value several chemical ecology-driven research studies their sustainable discovery novel therapeutic agents. These ecology-based approaches include activated defense, allelochemicals arising from interactions, spatio-temporal variations phylogeny-based approaches. In addition, innovative techniques used mapping surface well metabolite translocation within holobionts summarized. Chemical information related to maintenance symbioses biosyntheses specialized compounds be harnessed for biomedical applications, particularly microbial fermentation compound production. Furthermore, climate change ecology organisms—especially production, functionality perception allelochemicals—and its implications drug efforts will presented.
Language: Английский
Citations
30
Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)
Published: Feb. 5, 2025
Quorum sensing, first described in marine systems five decades ago, is a well-characterized chemical communication system used to coordinate bacterial gene expression and behavior; however, the impact of quorum sensing on interkingdom interactions has been vastly understudied. In this review, we examine how these molecules mediate between bacteria eukaryotes; influencing processes such as development, disease pathogenesis, microbiome regulation within ecosystems. We describe varied mechanisms eukaryotes have evolved interfere with signaling, crucial role signals play host-virus interactions, their exchange may be governed by outer membrane vesicles, prevalent systems. Here, present dynamic portrayal beyond communication, laying groundwork for future investigations roles shaping ecosystem structure function. A review examines system, shapes eukaryote
Language: Английский
Citations
1
InTech eBooks, Journal Year: 2011, Volume and Issue: unknown
Published: Nov. 16, 2011
Every ecosystem is a complex organization of carefully mixed life forms; dynamic and particularly sensible system. Consequently, their progressive decline may accelerate climate change vice versa, influencing flora fauna composition distribution, resulting in the loss biodiversity. Climate changes effects are principal topics this volume. Written by internationally renowned contributors, Biodiversity changing planet offers attractive study cases focused on biodiversity evaluations provisions several different ecosystems, analysing current condition many forms, covering very biogeographic zones planet.
Language: Английский
Citations
112