Frontiers in Pharmacology,
Journal Year:
2019,
Volume and Issue:
9
Published: Jan. 11, 2019
Despite
the
progress
that
has
occurred
in
recent
years
development
of
therapies
to
treat
painful
and
inflammatory
diseases,
there
is
still
a
need
for
effective
potent
analgesics
anti-inflammatory
drugs.
It
long
been
known
several
types
antioxidants
also
possess
analgesic
properties,
indicating
strong
relationship
between
inflammation
oxidative
stress.
Understanding
underlying
mechanisms
action
drugs,
as
well
essential
targets
disease
physiopathology,
novel
therapeutic
strategies.
The
Nuclear
factor-2
erythroid
related
(Nrf2)
transcription
factor
regulates
cellular
redox
status
through
endogenous
antioxidant
systems
with
simultaneous
activity.
This
review
summarizes
molecular
pharmacological
actions
screened
link
analgesic,
anti-inflammatory,
natural
products,
other
Nrf2
regulatory
system
based
on
emerging
evidences
from
experimental
models
new
clinical
trial
data.
Diseases,
Journal Year:
2016,
Volume and Issue:
4(4), P. 34 - 34
Published: Nov. 11, 2016
It
is
widely
believed
that
consuming
foods
and
beverages
have
high
concentrations
of
antioxidants
can
prevent
cardiovascular
diseases
many
types
cancer.
As
a
result,
articles
been
published
give
the
total
antioxidant
capacities
in
vitro.
However,
behave
quite
differently
vivo.
Some
them,
such
as
resveratrol
(in
red
wine)
epigallocatechin
gallate
or
EGCG
green
tea)
activate
nuclear
erythroid-2
like
factor-2
(Nrf2)
transcription
factor.
master
regulator
endogenous
cellular
defense
mechanisms.
Nrf2
controls
expression
detoxification
genes,
by
binding
to
response
elements
(AREs)
are
commonly
found
promoter
region
(and
other)
control
those
genes.
The
mechanisms
which
relieves
oxidative
stress
limits
cardiac
injury
well
progression
heart
failure
described.
Also,
ability
statins
induce
heart,
brain,
lung,
liver
mentioned.
there
negative
side
Nrf2.
When
over-activated,
it
cause
(not
prevent)
multi-drug
resistance
Frontiers in Pharmacology,
Journal Year:
2019,
Volume and Issue:
9
Published: Jan. 11, 2019
Despite
the
progress
that
has
occurred
in
recent
years
development
of
therapies
to
treat
painful
and
inflammatory
diseases,
there
is
still
a
need
for
effective
potent
analgesics
anti-inflammatory
drugs.
It
long
been
known
several
types
antioxidants
also
possess
analgesic
properties,
indicating
strong
relationship
between
inflammation
oxidative
stress.
Understanding
underlying
mechanisms
action
drugs,
as
well
essential
targets
disease
physiopathology,
novel
therapeutic
strategies.
The
Nuclear
factor-2
erythroid
related
(Nrf2)
transcription
factor
regulates
cellular
redox
status
through
endogenous
antioxidant
systems
with
simultaneous
activity.
This
review
summarizes
molecular
pharmacological
actions
screened
link
analgesic,
anti-inflammatory,
natural
products,
other
Nrf2
regulatory
system
based
on
emerging
evidences
from
experimental
models
new
clinical
trial
data.
