Bacterial Diversity Associated with the Coccolithophorid AlgaeEmiliania huxleyiandCoccolithus pelagicusf.braarudii DOI Creative Commons
David H. Green, Virginia Echavarri‐Bravo,

Debra Brennan

et al.

BioMed Research International, Journal Year: 2015, Volume and Issue: 2015, P. 1 - 15

Published: Jan. 1, 2015

Coccolithophores are unicellular calcifying marine phytoplankton that can form large and conspicuous blooms in the oceans make significant contributions to oceanic carbon cycling atmospheric CO 2 regulation. Despite their importance, bacterial diversity associated with these algae has not been explored for ecological or biotechnological reasons. Bacterial membership of Emiliania huxleyi Coccolithus pelagicus f. braarudii cultures was assessed using cultivation cultivation-independent methods. The communities were species rich compared other cultures. Community analysis identified specific taxa which cooccur all ( Marinobacter Marivita ). Hydrocarbon-degrading bacteria found presence Acidobacteria, Acidimicrobidae, Schlegelella , Thermomonas unprecedented but potentially explained by calcification coccolith production. One strain Acidobacteria cultivated is closely related a isolated from sponge. From this assessment coccolithophores, number opportunities evident, bioprospecting novel such as helping understand relationship between obligate hydrocarbonoclastic occurrence revealing have association may be suitable candidates means improve efficiency mass algal cultivation.

Language: Английский

Bioactive Metabolites from Terrestrial and Marine Actinomycetes DOI Creative Commons
Chananan Ngamcharungchit, Nutsuda Chaimusik, Watanalai Panbangred

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(15), P. 5915 - 5915

Published: Aug. 6, 2023

Actinomycetes inhabit both terrestrial and marine ecosystems are highly proficient in producing a wide range of natural products with diverse biological functions, including antitumor, immunosuppressive, antimicrobial, antiviral activities. In this review, we delve into the life cycle, ecology, taxonomy, classification actinomycetes, as well their varied bioactive metabolites recently discovered between 2015 2023. Additionally, explore promising strategies to unveil investigate new metabolites, encompassing genome mining, activation silent genes through signal molecules, co-cultivation approaches. By presenting comprehensive up-to-date hope offer potential solution uncover novel compounds essential

Language: Английский

Citations

52
Potential of marine natural products against drug-resistant fungal, viral, and parasitic infections DOI
Usama Ramadan Abdelmohsen,

Srikkanth Balasubramanian,

Tobias A. Oelschlaeger

et al.

The Lancet Infectious Diseases, Journal Year: 2016, Volume and Issue: 17(2), P. e30 - e41

Published: Dec. 12, 2016

Language: Английский

Citations

137
Cave Actinobacteria as Producers of Bioactive Metabolites DOI Creative Commons
Pharada Rangseekaew, Wasu Pathom-aree

Frontiers in Microbiology, Journal Year: 2019, Volume and Issue: 10

Published: March 22, 2019

Recently, there is an urgent need for new drugs due to the emergence of drug resistant pathogenic microorganisms and infectious diseases. Members phylum Actinobacteria are promising source bioactive compounds notably antibiotics. The search such shifted extreme or underexplored environments increase possibility discovery. Cave ecosystems have attracted interest research community because their unique characteristics microbiome residing inside including actinobacteria. At time writing, 42 species in 28 genera actinobacteira reported from cave habitats. Novel been isolated characterized. This present mini-review focuses on diversity actinobacteria metabolites produced by these associated 1999-2018.

Language: Английский

Citations

122
Marine actinobacteria associated with marine organisms and their potentials in producing pharmaceutical natural products DOI
Valliappan Karuppiah, Wei Sun, Zhiyong Li

et al.

Applied Microbiology and Biotechnology, Journal Year: 2014, Volume and Issue: 98(17), P. 7365 - 7377

Published: July 26, 2014

Language: Английский

Citations

113
Marine bacteria as source of antimicrobial compounds DOI
Paolo Stincone, Adriano Brandelli

Critical Reviews in Biotechnology, Journal Year: 2020, Volume and Issue: 40(3), P. 306 - 319

Published: Jan. 28, 2020

The marine environment encompasses a huge biological diversity and can be considered as an underexplored location for prospecting bioactive molecules. In this review, the current state of art about antimicrobial molecules from bacteria has been summarized considering main phylum sources evolved in environment. Considering last two decades, we have found most studied group producers substances with activity is Firmicutes phylum, particular strains Bacillus genus. reason that attributed to difficult cultivation typical Actinobacteria sediment, whose members are major land environments. However, reversed trend observed recent years increasing number reports settling on Actinobacteria. Great chemical structures identified, such fijimicyns lynamicyns Actinomycetes macrolactins produced by Bacillus.

Language: Английский

Citations

107
Molecules to Ecosystems: Actinomycete Natural Products In situ DOI Creative Commons

Scott W. Behie,

Bailey Bonet,

Vineetha M. Zacharia

et al.

Frontiers in Microbiology, Journal Year: 2017, Volume and Issue: 7

Published: Jan. 16, 2017

Actinomycetes, filamentous actinobacteria found in numerous ecosystems around the globe, produce a wide range of clinically useful natural products (NP). In environments, actinomycetes live dynamic communities where environmental cues and ecological interactions likely influence NP biosynthesis. Our current understating these cues, roles NP, is its infancy. We postulate that understanding context which actinomycete metabolites are made fundamental to advancing discovery novel NP. this review we explore relevance their secondary from varying ecosystems, suggest investigating ecology warrants particular attention with respect metabolite discovery. Furthermore, focus on chemical situ analysis consider implications for biosynthesis at ecosystem scales.

Language: Английский

Citations

92
Antifungal potential of marine natural products DOI
Ebaa M. El‐Hossary, Cheng Cheng, Mostafa M. Hamed

et al.

European Journal of Medicinal Chemistry, Journal Year: 2016, Volume and Issue: 126, P. 631 - 651

Published: Nov. 14, 2016

Language: Английский

Citations

89
Actinobacteria Isolated From Laminaria ochroleuca: A Source of New Bioactive Compounds DOI Creative Commons
Mariana Girão, Inês Ribeiro, Tiago Ribeiro

et al.

Frontiers in Microbiology, Journal Year: 2019, Volume and Issue: 10

Published: April 9, 2019

Nature is the major reservoir of biologically active molecules. The urgent need finding novel molecules for pharmaceutical application prompting research underexplored environments, such as marine ecosystems. Here, we investigated cultivable actinobacteria associated with macroalgae Laminaria ochroleuca and assessed their potential to produce compounds antimicrobial or anticancer activities. A specimen L. was collected in a rocky shore northern Portugal, fragments tissues from different parts (holdfast, stipe, blades) were surface sterilized plated three culture media selective actinobacteria. total 90 actinobacterial strains isolated, most which affiliated genus Streptomyces. Isolates genera Isoptericola, Rhodococcus, Nonomuraeae, Nocardiopsis, Microbispora, Microbacterium also obtained. Organic extracts isolates tested activity using agar-based disk diffusion method, followed by determination minimum inhibitory concentration (MIC) values. Forty-five inhibited growth Candida albicans and/or Staphylococcus aureus, MIC values ranging <0.5 1000 μg mL-1. on two human cancer cell lines. Twenty-eight affected viability at least one line (breast carcinoma T-47D neuroblastoma SH-SY5Y) non-carcinogenic endothelial (hCMEC/D3). Seven cells only. This study revealed that rich source promising activities suggests may be valuable and, consequently, new biotechnological importance.

Language: Английский

Citations

80
Microbial Natural Products as Potential Inhibitors of SARS-CoV-2 Main Protease (Mpro) DOI Creative Commons
Ahmed M. Sayed, Hani A. Alhadrami, Ahmed O. El‐Gendy

et al.

Microorganisms, Journal Year: 2020, Volume and Issue: 8(7), P. 970 - 970

Published: June 29, 2020

The main protease (Mpro) of the newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was subjected to hyphenated pharmacophoric-based and structural-based virtual screenings using a library microbial natural products (>24,000 compounds). Subsequent filtering resulted hits according Lipinski’s rules applied select only drug-like molecules. Top-scoring were further filtered out depending on their ability show constant good binding affinities towards molecular dynamic simulation (MDS)-derived enzyme’s conformers. Final MDS experiments performed ligand–protein complexes (compounds 1–12, Table S1) verify modes calculate free energy. Consequently, final selection six compounds (1–6) proposed possess high potential as anti-SARS-CoV-2 drug candidates. Our study provides insight into role Mpro structural flexibility during interactions with possible inhibitors sheds light structure-based design anti-coronavirus disease 2019 (COVID-19) therapeutics targeting SARS-CoV-2.

Language: Английский

Citations

72
Actinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds DOI Creative Commons
Denis V. Axenov‐Gribanov,

Irina V. Voytsekhovskaya,

Bogdan Tokovenko

et al.

PLoS ONE, Journal Year: 2016, Volume and Issue: 11(2), P. e0149216 - e0149216

Published: Feb. 22, 2016

Actinobacteria isolated from unstudied ecosystems are one of the most interesting and promising sources novel biologically active compounds. Cave unusual rarely studied. Here, we report isolation characterization ten new actinobacteria strains an ancient underground lake moonmilk speleothem biggest conglomeratic karstic cave in Siberia with a focus on biological activity obtained metabolite dereplication strain. Streptomyces genera isolates demonstrated antibacterial antifungal activities. Some were able to inhibit growth pathogenic Candida albicans.

Language: Английский

Citations

78