Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

ACS Applied Materials & Interfaces, Journal Year: 2016, Volume and Issue: 8(33), P. 21107 - 21133

Published: June 29, 2016

Smart drug delivery systems (DDSs) have attracted the attention of many scientists, as carriers that can be stimulated by changes in environmental parameters such temperature, pH, light, electromagnetic fields, mechanical forces, etc. These smart nanocarriers release their cargo on demand when target is reached and stimulus applied. Using techniques nanotechnology, these tailored to target-specific, exhibit delayed or controlled drugs. Temperature-responsive are one most important groups nanoparticles (NPs) been investigated during past decades. Temperature either act an external heat applied from outside, internal pathological lesions a naturally elevated termperature. A low critical solution temperature (LCST) special feature some polymeric materials, temperature-responsive designed based this feature. In review, we attempt summarize recent efforts prepare innovative discuss novel applications.

Language: Английский

---

Advancing porphyrin's biomedical utility via supramolecular chemistry

Chemical Society Reviews, Journal Year: 2017, Volume and Issue: 46(21), P. 6433 - 6469

Published: Jan. 1, 2017

Enhancing existing porphyrin functionality and introducing new capabilities via supramolecular chemistry.

Language: Английский

---

Investigational nanomedicines in 2016: a review of nanotherapeutics currently undergoing clinical trials

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2016, Volume and Issue: 9(1)

Published: June 16, 2016

Nanomedicine is a relatively new field that rapidly evolving. Formulation of drugs on the nanoscale imparts many physical and biological advantages. Such advantages can in turn translate into improved therapeutic efficacy reduced toxicity. While approximately 50 nanotherapeutics have already entered clinical practice, greater number are undergoing investigation for variety indications. This review aims to examine all nanoformulations currently their outlook ultimate translation. WIREs Nanomed Nanobiotechnol 2017, 9:e1416. doi: 10.1002/wnan.1416 article categorized under: Therapeutic Approaches Drug Discovery > Emerging Technologies

Language: Английский

---

Albumin nanostructures as advanced drug delivery systems

Expert Opinion on Drug Delivery, Journal Year: 2016, Volume and Issue: 13(11), P. 1609 - 1623

Published: May 24, 2016

Introduction: One of the biggest impacts that nanotechnology has made on medicine and biology, been in area drug delivery systems (DDSs). Many drugs suffer from serious problems concerning insolubility, instability biological environments, poor uptake into cells tissues, sub-optimal selectivity for targets unwanted side effects. Nanocarriers can be designed as DDSs to overcome many these drawbacks. most versatile building blocks prepare nanocarriers is ubiquitous, readily available inexpensive protein, serum albumin.Areas covered: This review covers use different types albumin (human, bovine, rat, chicken egg) nanoparticle microparticle-based structures bind drugs. Various methods have used modify structure. A range targeting ligands attached recognized by specific cell receptors are expressed target or tissues.Expert opinion: The particular advantages include ready availability, ease chemical modification, good biocompatibility, low immunogenicity. regulatory approvals received several albumin-based therapeutic agents suggest this approach will continue successfully explored.

Language: Английский

---

Entry of nanoparticles into cells: the importance of nanoparticle properties

Polymer Chemistry, Journal Year: 2017, Volume and Issue: 9(3), P. 259 - 272

Published: Dec. 18, 2017

Knowledge of the interactions between nanoparticles (NPs) and cell membranes is great importance for design safe efficient nanomedicines.

Language: Английский

---