3D printing of hydrogels: Rational design strategies and emerging biomedical applications

Materials Science and Engineering R Reports, Journal Year: 2020, Volume and Issue: 140, P. 100543 - 100543

Published: Feb. 18, 2020

3D printing alias additive manufacturing can transform virtual models created by computer-aided design (CAD) into physical objects in a layer-by-layer manner dispensing with conventional molding or machining. Since the incipiency, significant advancements have been achieved understanding process of and relationship component, structure, property application objects. Because hydrogels are one most feasible classes ink materials for this field has rapidly advancing, Review focuses on hydrogel designs development advanced hydrogel-based biomaterial inks bioinks printing. It covers techniques including laser (stereolithography, two-photon polymerization), extrusion (3D plotting, direct writing), inkjet printing, bioprinting, 4D bioprinting. provides comprehensive overview discussion tailorability material, mechanical, physical, chemical biological properties to enable The range hydrogel-forming polymers covered encompasses biopolymers, synthetic polymers, polymer blends, nanocomposites, functional cell-laden systems. representative biomedical applications selected demonstrate how is being exploited tissue engineering, regenerative medicine, cancer research, vitro disease modeling, high-throughput drug screening, surgical preparation, soft robotics flexible wearable electronics. Incomparable thermoplastics, thermosets, ceramics metals, playing pivotal role creation (bio)systems customizable way. An outlook future directions presented.

Language: Английский

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Scaffold Fabrication Technologies and Structure/Function Properties in Bone Tissue Engineering

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(21)

Published: March 8, 2021

Abstract Bone tissue engineering (BTE) is a rapidly growing field aiming to create biofunctional that can integrate and degrade in vivo treat diseased or damaged tissue. It has become evident scaffold fabrication techniques are very important dictating the final structural, mechanical properties, biological response of implanted biomaterials. A comprehensive review current accomplishments on techniques, their structure, function properties for BTE provided herein. Different types biomaterials ranging from inorganic natural synthetic polymers related composites processing presented. Emergent scaffolding such as electrospinning, freeze‐drying, bioprinting, decellularization also discussed. Strategies improve vascularization potential immunomodulation, which considered grand challenge scaffolding,

Language: Английский

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Gelatin-polysaccharide composite scaffolds for 3D cell culture and tissue engineering: Towards natural therapeutics

Bioengineering & Translational Medicine, Journal Year: 2018, Volume and Issue: 4(1), P. 96 - 115

Published: Nov. 30, 2018

Abstract Gelatin is a promising material as scaffold with therapeutic and regenerative characteristics due to its chemical similarities the extracellular matrix (ECM) in native tissues, biocompatibility, biodegradability, low antigenicity, cost‐effectiveness, abundance, accessible functional groups that allow facile modifications other biomaterials or biomolecules. Despite advantages of gelatin, poor mechanical properties, sensitivity enzymatic degradation, high viscosity, reduced solubility concentrated aqueous media have limited applications encouraged development gelatin‐based composite hydrogels. The drawbacks gelatin may be surmounted by synergistically combining it wide range polysaccharides. addition polysaccharides advantageous mimicking ECM, which largely contains proteoglycans glycoproteins. Moreover, gelatin–polysaccharide benefit from resilience, stability, thermal expansion, improved hydrophilicity, antimicrobial anti‐inflammatory wound healing potential. Here, we discuss how provides approach for developing superior biomaterials. We review gelatin–polysaccharides scaffolds their cell culture tissue engineering, providing an outlook future this family advanced natural therapeutics.

Language: Английский

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Articular cartilage and osteochondral tissue engineering techniques: Recent advances and challenges

Bioactive Materials, Journal Year: 2021, Volume and Issue: 6(12), P. 4830 - 4855

Published: May 28, 2021

In spite of the considerable achievements in field regenerative medicine past several decades, osteochondral defect regeneration remains a challenging issue among diseases musculoskeletal system because spatial complexity units composition, structure and functions. order to repair hierarchical tissue involving different layers articular cartilage, cartilage-bone interface subchondral bone, traditional clinical treatments including palliative reparative methods have showed certain improvement pain relief filling. It is development engineering that has provided more promising results regenerating neo-tissues with comparable compositional, structural functional characteristics native tissues. Here this review, some basic knowledge anatomical classification will be first introduced. Then we highlight recent progress from perspectives scaffold design, cell encapsulation signaling factor incorporation bioreactor application. Clinical products for analyzed summarized later. Moreover, discuss current obstacles future directions regenerate damaged

Language: Английский

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Thermoresponsive polysaccharides and their thermoreversible physical hydrogel networks

Carbohydrate Polymers, Journal Year: 2018, Volume and Issue: 207, P. 143 - 159

Published: Nov. 19, 2018

Language: Английский

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Cationic, anionic and neutral polysaccharides for skin tissue engineering and wound healing applications

International Journal of Biological Macromolecules, Journal Year: 2021, Volume and Issue: 192, P. 298 - 322

Published: Oct. 11, 2021

Language: Английский

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Advances in bioactive glass-containing injectable hydrogel biomaterials for tissue regeneration

Acta Biomaterialia, Journal Year: 2021, Volume and Issue: 136, P. 1 - 36

Published: Sept. 23, 2021

Language: Английский

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Polysaccharide-based hydrogel with photothermal effect for accelerating wound healing

Carbohydrate Polymers, Journal Year: 2022, Volume and Issue: 299, P. 120228 - 120228

Published: Oct. 14, 2022

Language: Английский

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A Guide to Polysaccharide-Based Hydrogel Bioinks for 3D Bioprinting Applications

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(12), P. 6564 - 6564

Published: June 12, 2022

Three-dimensional (3D) bioprinting is an innovative technology in the biomedical field, allowing fabrication of living constructs through approach layer-by-layer deposition cell-laden inks, so-called bioinks. An ideal bioink should possess proper mechanical, rheological, chemical, and biological characteristics to ensure high cell viability production tissue with dimensional stability shape fidelity. Among several types bioinks, hydrogels are extremely appealing as they have many similarities extracellular matrix, providing a highly hydrated environment for proliferation tunability terms mechanical rheological properties. Hydrogels derived from natural polymers, polysaccharides, particular, excellent platform mimic given their low cytotoxicity, hydrophilicity, diversity structures. In fact, polysaccharide-based trendy materials 3D since abundant combine adequate physicochemical biomimetic features development novel Thus, this review portrays most relevant advances hydrogel bioinks bioprinting, focusing on last five years, emphasis properties, advantages, limitations, considering polysaccharide families classified according source, namely seaweed, higher plants, microbial, animal (particularly crustaceans) origin.

Language: Английский

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Intervertebral disc degeneration—Current therapeutic options and challenges

Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11

Published: July 6, 2023

Degeneration of the intervertebral disc (IVD) is a normal part aging. Due to spine's declining function and development pain, it may affect one's physical health, mental socioeconomic status. Most degeneration (IVDD) therapies today focus on symptoms low back pain rather than underlying etiology or mechanical disc. The deteriorated typically not restored by conservative surgical that largely correcting structural abnormalities. To enhance clinical outcome quality life patient, several therapeutic modalities have been created. In this review, we discuss genetic environmental causes IVDD describe promising modern endogenous exogenous approaches including their applicability relevance process.

Language: Английский

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