Spirocyclic compounds as innovative tools in drug discovery for medicinal chemists DOI
Marina T. Varela, Gleiston G. Dias, Luiz Fernando N. de Oliveira

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 287, P. 117368 - 117368

Published: Feb. 6, 2025

Language: Английский

Electrochemical Dearomative Spirocyclization DOI
Nan Li, Zhaojiang Shi,

Wei‐Zhen Wang

et al.

Chemistry - An Asian Journal, Journal Year: 2023, Volume and Issue: 18(9)

Published: March 15, 2023

Electrochemical dearomative spirocyclization serves as a green and sustainable approach to convert the flat, two-dimension aromatic feedstock into value-added three-dimension spirocyclic architectures. This review highlights recent advances, emphasizes mechanistic discussions, showcases synthetic applications of this emerging versatile powerful transformation.

Language: Английский

Citations

36
Recent advances in the application of deep eutectic solvents for the synthesis of Spiro heterocyclic scaffolds via multicomponent reactions DOI
Ramin Javahershenas

Journal of Molecular Liquids, Journal Year: 2023, Volume and Issue: 385, P. 122398 - 122398

Published: June 20, 2023

Language: Английский

Citations

27
Enantioselective C–H bond functionalization under Co(iii)-catalysis DOI

Bholanath Garai,

Abir Das,

Doppalapudi Vineet Kumar

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(25), P. 3354 - 3369

Published: Jan. 1, 2024

Enantioselective C–H functionalization relies on 4d and 5d metals, but with their depletion, sustainable alternatives using 3d metals are crucial.

Language: Английский

Citations

13
Synthesis of 1,7-Fused Indolines Tethered with Spiroindolinone Based on C–H Activation Strategy with Air as a Sustainable Oxidant DOI
Xing He,

Kangli Liu,

Shengnan Yan

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(3), P. 1880 - 1897

Published: Jan. 22, 2024

Herein, we present an efficient synthesis of 1,7-fused indolines tethered with a spiroindolinonyl moiety through the cascade reaction indolin-1-yl(aryl)methanimines diazo oxindoles. To best our knowledge, this is first example in which indoline skeleton was constructed along simultaneous introduction spiro element initiated by C–H bond activation indoline. In forming title product, substrate and coupling partner demonstrated unprecedented pattern latter acts as C1 synthon to participate construction spirocyclic scaffold reductive elimination key seven-membered Ru(II) species using air effective sustainable oxidant regenerate active catalyst. Moreover, studies on cytotoxicity selected products against several human cancer cell lines their potential lead compounds for development anticancer drugs. With notable features such simple economical substrates, pharmaceutically valuable sophisticated skeleton, mild conditions, cost-free oxidants, high efficiency, excellent compatibility diverse functional groups, scalability, method expected find wide applications related areas.

Language: Английский

Citations

10
Spirocyclic compounds as innovative tools in drug discovery for medicinal chemists DOI
Marina T. Varela, Gleiston G. Dias, Luiz Fernando N. de Oliveira

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 287, P. 117368 - 117368

Published: Feb. 6, 2025

Language: Английский

Citations

1