Carbon Dots for In Vivo Bioimaging and Theranostics

Small, Journal Year: 2019, Volume and Issue: 15(32)

Published: Feb. 18, 2019

Carbon dots (CDs), a kind of carbon material discovered accidentally, exhibit unexpected advantages in fluorescence imaging/sensing such as photostability, biocompatibility, and low toxicity. For emerging theranostics, an interdiscipline created by integrating therapy diagnostics, CDs are good candidates when they combined with targeted chemo/gene/photodynamic/photothermal therapeutic moieties. Here, the development nanomedicine is reviewed from their use original imaging agents and/or drug carriers to multifunctional theranostic systems. Finally, challenges prospects next-generation CD-based theranostics for clinical applications also discussed.

Language: Английский

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Carbon dots: Biomacromolecule interaction, bioimaging and nanomedicine

Coordination Chemistry Reviews, Journal Year: 2017, Volume and Issue: 343, P. 256 - 277

Published: June 7, 2017

Language: Английский

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Carbon dots: surface engineering and applications

Journal of Materials Chemistry B, Journal Year: 2016, Volume and Issue: 4(35), P. 5772 - 5788

Published: Jan. 1, 2016

Carbon dots have attracted a great deal of attention because their high performance, cheap and facile preparation, potential applications in wide area. In order to broaden applications, especially meet specific requirements, surface engineering, including tailoring functional group coating subsequent chemical modification as required, is an effective strategy for further functionalization carbon dots. this article, representative approaches the with various groups, strategies conjugating materials onto via covalent bonds, electrostatic interactions hydrogen bonds are highlighted, well results from explorations target modulated sensing, accurate drug delivery bioimaging at resolution.

Language: Английский

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Surface modification and chemical functionalization of carbon dots: a review

Microchimica Acta, Journal Year: 2018, Volume and Issue: 185(9)

Published: Aug. 20, 2018

Language: Английский

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Label-Free Carbon-Dots-Based Ratiometric Fluorescence pH Nanoprobes for Intracellular pH Sensing

Analytical Chemistry, Journal Year: 2016, Volume and Issue: 88(15), P. 7837 - 7843

Published: June 23, 2016

Measuring pH in living cells is of great importance for better understanding cellular functions as well providing pivotal assistance early diagnosis diseases. In this work, we report the first use a novel kind label-free carbon dots intracellular ratiometric fluorescence sensing. By simple one-pot hydrothermal treatment citric acid and basic fuchsin, showing dual emission bands at 475 545 nm under single-wavelength excitation were synthesized. It demonstrated that intensities as-synthesized two emissions are pH-sensitive simultaneously. The intensity ratio (I475 nm/I545 nm) linear against values from 5.2 to 8.8 buffer solution, affording capability probes also displays show excellent reversibility photostability measurements. With nanoprobe, quantitative imaging using detection successfully applied HeLa cells. contrast most reported nanomaterials-based sensors which rely on attachment additional dyes, these carbon-dots-based low toxicity, easy synthesize, free labels.

Language: Английский

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Carbon dots: Applications in bioimaging and theranostics

International Journal of Pharmaceutics, Journal Year: 2019, Volume and Issue: 564, P. 308 - 317

Published: April 20, 2019

Language: Английский

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Recent advances in carbon dots for bioimaging applications

Nanoscale Horizons, Journal Year: 2019, Volume and Issue: 5(2), P. 218 - 234

Published: Oct. 16, 2019

This review summarized recent advances in CDs-based bioimaging including in vitro imaging delivering CDs into different types of cells and vivo applications distribution uptake CDs, imaging-guild drug delivery tumor therapeutics.

Language: Английский

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Cancer Targeting and Drug Delivery Using Carbon-Based Quantum Dots and Nanotubes

Molecules, Journal Year: 2018, Volume and Issue: 23(2), P. 378 - 378

Published: Feb. 10, 2018

Currently cancer treatment is in large part non-specific with respect to treatment. Medication often harsh on patients, whereby they suffer several undesired side effects as a result. Carbon-based nanoparticles have attracted attention recent years due their ability act platform for the attachment of drugs and/or ligands. Relatively simple models are used research, wherein carbon conjugated ligand that specific an overexpressed receptor imaging and drug delivery These confer unique properties or vehicle nontoxic nature high fluorescence qualities. Chief among ongoing research within carbon-based emerge dots (C-dots) nanotubes (CNTs). In this review, aforementioned will be discussed use doxorubicin gemcitabine based vehicles, well ligand-mediated targeted therapy. Further directions current field also discussed.

Language: Английский

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Transferrin conjugated nontoxic carbon dots for doxorubicin delivery to target pediatric brain tumor cells

Nanoscale, Journal Year: 2016, Volume and Issue: 8(37), P. 16662 - 16669

Published: Jan. 1, 2016

Among various cancers, pediatric brain tumors represent the most common cancer type in children and second cause of related deaths. Anticancer drugs therapies, such as doxorubicin (Dox), have severe side effects on patients during chemotherapy, especially for their bodies are still under development. These believed to be due lack a delivery system with high efficacy targeting selectivity, resulting serious damages normal cells. To improve transferrin (Trans) receptor mediated endocytosis can utilized drug design, receptors expressed blood barrier (BBB) often over tumor Carbon dots (C-Dots) recently emerged benign nanoparticles biomedical applications owing good water solubility, tunable surface functionalities excellent biocompatibility. The unique characteristics C-Dots make them promising candidates In this study, carbon dots-transferrin-doxorubicin covalent conjugate (C-Dots-Trans-Dox) was synthesized, characterized by different spectroscopic techniques investigated potential application anticancer treat tumors. Our vitro results demonstrate greater uptake C-Dots-Trans-Dox compared Dox alone presumably levels these Experiment showed that at 10 nM significantly more cytotoxic than alone, reducing viability 14-45%, across multiple cell lines.

Language: Английский

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Carbon dots: emerging theranostic nanoarchitectures

Drug Discovery Today, Journal Year: 2018, Volume and Issue: 23(6), P. 1219 - 1232

Published: Jan. 31, 2018

Language: Английский

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