Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
61(40)
Published: Aug. 24, 2022
Improving
the
stability
of
sensitive
catalytic
systems
is
an
emerging
research
topic
in
catalysis
field.
However,
current
design
heterogeneous
catalysts
mainly
improves
their
performance.
This
paper
presents
a
single-atom
catalyst
(SAC)
strategy
to
improve
cobalt-catalysed
fluorination
acyl
chlorides.
A
stable
Co-F
intermediate
can
be
formed
through
oxidative
Co1
-N4
@NC
SAC,
which
replace
unstable
high-valent
cobalt
system
and
avoid
use
phosphine
ligands.
In
SAC
system,
KF
employed
as
fluorinating
reagent
AgF,
applied
various
substrates
scale-up
conversion
with
high
turnover
numbers
(TON=1.58×106
).
work
also
shows
that
inorganic
SACs
have
tremendous
potential
for
organofluorine
chemistry,
it
provides
good
reference
follow-up
studies
on
structure-activity
relationship
between
chemical
reaction
mechanisms.
Chemical Society Reviews,
Journal Year:
2018,
Volume and Issue:
47(15), P. 5786 - 5865
Published: Jan. 1, 2018
This
review
provides
an
overview
of
the
use
electrochemistry
as
appealing
platform
for
expediting
carbon–hydrogen
functionalization
and
carbon–nitrogen
bond
formation.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
122(2), P. 1875 - 1924
Published: Aug. 6, 2021
Direct
photocatalyzed
hydrogen
atom
transfer
(d-HAT)
can
be
considered
a
method
of
choice
for
the
elaboration
aliphatic
C–H
bonds.
In
this
manifold,
photocatalyst
(PCHAT)
exploits
energy
photon
to
trigger
homolytic
cleavage
such
bonds
in
organic
compounds.
Selective
bond
may
achieved
by
judicious
abstractor
(key
parameters
are
electronic
character
and
molecular
structure),
as
well
reaction
additives.
Different
classes
PCsHAT
available,
including
aromatic
ketones,
xanthene
dyes
(Eosin
Y),
polyoxometalates,
uranyl
salts,
metal-oxo
porphyrin
tris(amino)cyclopropenium
radical
dication.
The
processes
(mainly
C–C
formation)
most
cases
carried
out
under
mild
conditions
with
help
visible
light.
aim
review
is
offer
comprehensive
survey
synthetic
applications
d-HAT.
Chemical Reviews,
Journal Year:
2018,
Volume and Issue:
118(7), P. 3887 - 3964
Published: April 2, 2018
New
methods
for
preparation
of
tailor-made
fluorine-containing
compounds
are
in
extremely
high
demand
nearly
every
sector
chemical
industry.
The
asymmetric
construction
quaternary
C-F
stereogenic
centers
is
the
most
synthetically
challenging
and,
consequently,
least
developed
area
research.
As
a
reflection
this
apparent
methodological
deficit,
pharmaceutical
drugs
featuring
constitute
less
than
1%
all
medicines
currently
on
market
or
clinical
development.
Here
we
provide
comprehensive
review
current
research
activity
area,
including
such
general
directions
as
electrophilic
fluorination
via
organocatalytic
and
transition-metal
catalyzed
reactions,
elaboration
substrates
alkylations,
Mannich,
Michael,
aldol
additions,
cross-coupling
biocatalytic
approaches.
Chemical Reviews,
Journal Year:
2017,
Volume and Issue:
117(13), P. 8710 - 8753
Published: June 27, 2017
Partially
fluorinated
alkanes,
arenes,
and
alkenes
can
be
transformed
by
a
variety
of
transition
metal
lanthanide
systems.
Although
the
C-H
bond
is
weaker
than
C-F
regardless
hybridization
carbon,
reaction
at
usually
more
exothermic
corresponding
bonds.
Both
bonds
are
activated
systems,
but
preference
for
activating
these
depends
on
nature
hydrocarbon
system,
so
that
directed
exclusively
toward
or
yield
mixture
products.
Additionally,
presence
fluorine
differentiates
between
different
positions
resulting
in
regioselective
activation;
paradoxically,
strongest
reacts
preferentially.
The
purpose
this
review
to
describe
field
reactions
partially
substrates
with
atoms,
ions,
molecular
complexes.
controlling
physical
properties
(thermodynamics
kinetics)
described
first,
followed
description
stoichiometric
reactions,
competition
activations
as
focus.
A
few
representative
catalytic
systems
discussed.
also
highlights
benefit
combining
experimental
theoretical
studies.
Journal of the American Chemical Society,
Journal Year:
2018,
Volume and Issue:
140(15), P. 5004 - 5008
Published: March 27, 2018
Through
fine-tuning
of
reagent
and
base
structure,
sulfonyl
fluorides
can
efficiently
fluorinate
diverse
classes
alcohols.
We
show
that
machine
learning
map
the
intricate
reaction
landscape
enable
accurate
prediction
high-yielding
conditions
for
untested
substrates.
Organic Process Research & Development,
Journal Year:
2020,
Volume and Issue:
24(4), P. 470 - 480
Published: March 5, 2020
Fluorinated
organic
molecules
are
increasingly
being
prepared
for
a
variety
of
applications,
including
pharmaceutical
products.
However,
the
supply
chain
to
access
necessary
raw
materials,
which
originate
primarily
from
calcium
fluoride,
is
often
not
considered,
may
be
difficult
at
commercial
scale,
and
has
become
destabilized
as
more
stringent
environmental
policies
justifiably
enforced.
This
manuscript
presents
an
overview
preparation
use
simple
organofluorinated
intermediates
reagents
challenges
associated
with
them.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(18), P. 9928 - 9950
Published: April 24, 2023
This
Perspective
surveys
the
progress
and
current
limitations
of
nucleophilic
fluorination
methodologies.
Despite
long
rich
history
C(sp3)–F
bond
construction
in
chemical
research,
inherent
challenges
associated
with
this
transformation
have
largely
constrained
to
a
privileged
reaction
platform.
In
recent
years,
Doyle
group─along
many
others─has
pursued
study
development
intent
generating
deeper
mechanistic
understanding,
developing
user-friendly
reagents,
contributing
invention
synthetic
methods
capable
enabling
radiofluorination.
Studies
from
our
laboratory
are
discussed
along
developments
others
field.
Fluoride
reagent
implications
identity
highlighted.
We
also
outline
space
inaccessible
by
technologies
series
future
directions
field
that
can
potentially
fill
existing
dark
spaces.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(3), P. 281 - 281
Published: Feb. 22, 2024
The
fluorine
atom
possesses
many
intrinsic
properties
that
can
be
beneficial
when
incorporated
into
small
molecules.
These
include
the
atom’s
size,
electronegativity,
and
ability
to
block
metabolic
oxidation
sites.
Substituents
feature
fluorine-containing
groups
are
currently
prevalent
in
drugs
lower
cholesterol,
relieve
asthma,
treat
anxiety
disorders,
as
well
improve
chemical
of
various
medications
imaging
agents.
dye
scaffolds
(fluorescein/rhodamine,
coumarin,
BODIPY,
carbocyanine,
squaraine
dyes)
reported
will
address
incorporation
scaffold
contribution
it
provides
its
application
an
agent.
It
is
also
important
recognize
radiolabeled
atoms
used
for
PET
early
detection
diseases.
This
review
discuss
benefits
incorporating
molecules
give
examples
fluorinated
pharmaceutical
industry
techniques.
