Synergistic Chemotherapy and Photodynamic Therapy of Endophthalmitis Mediated by Zeolitic Imidazolate Framework‐Based Drug Delivery Systems

Small, Journal Year: 2019, Volume and Issue: 15(47)

Published: Oct. 7, 2019

Endophthalmitis, derived from the infections of pathogens, is a common complication during use ophthalmology-related biomaterials and after ophthalmic surgery. Herein, aiming at efficient photodynamic therapy (PDT) bacterial biofilm eradication endophthalmitis, pH-responsive zeolitic imidazolate framework-8-polyacrylic acid (ZIF-8-PAA) material constructed for infection-targeted delivery ammonium methylbenzene blue (MB), broad-spectrum photosensitizer antibacterial agent. Polyacrylic (PAA) incorporated into system to achieve higher pH responsiveness better drug loading capacity. MB-loaded ZIF-8-PAA nanoparticles are modified with AgNO3 /dopamine in situ reduction silver (AgNPs), followed by secondary modification vancomycin/NH2 -polyethylene glycol (Van/NH2 -PEG), leading formation composite nanomaterial, ZIF-8-PAA-MB@AgNPs@Van-PEG. Dynamic light scattering, transmission electron microscopy, UV-vis spectral analysis used explore synthesis, release, related properties. In terms biological performance, vitro studies against three kinds bacteria, i.e., Escherichia coli, Staphylococcus aureus, methicillin-resistant S. suggest an obvious superiority PDT/AgNPs any single strategy. Both retinal pigment epithelium cellular biocompatibility experiments vivo mice endophthalmitis models verify function nanomaterials.

Language: Английский

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Engineering the drug carrier biointerface to overcome biological barriers to drug delivery

Advanced Drug Delivery Reviews, Journal Year: 2020, Volume and Issue: 167, P. 89 - 108

Published: June 11, 2020

Language: Английский

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Antibacterial Hybrid Hydrogels

Macromolecular Bioscience, Journal Year: 2020, Volume and Issue: 21(1)

Published: Sept. 3, 2020

Abstract Bacterial infectious diseases and bacterial‐infected environments have been threatening the health of human beings all over world. In view increased bacteria resistance caused by overuse or improper use antibiotics, antibacterial biomaterials are developed as substitutes for antibiotics in some cases. Among them, hydrogels attracting more attention due to easy preparation process diversity structures changing their chemical cross‐linkers via covalent bonds noncovalent physical interactions, which can endow them with various specific functions such high toughness stretchability, injectability, self‐healing, tissue adhesiveness rapid hemostasis, loading controlled drug release, superior biocompatibility antioxidation well good conductivity. this review, recent progress hydrogel including fabrication methodologies, interior structures, performances, mechanisms, applications is summarized. According bacteria‐killing modes hydrogels, several representative silver nanoparticles‐based hydrogel, photoresponsive photothermal photocatalytic, self‐bacteria‐killing inherent peptides cationic polymers, antibiotics‐loading focused on. Furthermore, current challenges discussed future perspectives field also proposed.

Language: Английский

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Cationization-Enhanced Type I and Type II ROS Generation for Photodynamic Treatment of Drug-Resistant Bacteria

ACS Nano, Journal Year: 2022, Volume and Issue: 16(6), P. 9130 - 9141

Published: May 18, 2022

Photodynamic therapy as an emerging phototheranostic approach holds great potential for antibacterial treatment, but is limited by compromised reactive oxygen species (ROS) generation in aggregate and hypoxic microenvironment. Herein, we report a molecular cationization to boost the ROS, especially type I ROS of aggregation-induced emission (AIE) photosensitizers photodynamic treatment drug-resistant bacteria. Such reinforces electron-accepting ability cationic moiety, promotes intersystem crossing (ISC), increases electron separation transfer processes. The resultant CTBZPyI exhibits largely enhanced with predominant hydroxyl radical over its neutral counterpart aggregate. Moreover, also confers bacterial binding moderate inactivation dark. Further light irradiation leads superb performance, which healing process MRSA-infected wound. strategy expected be general design highly effective infection treatment.

Language: Английский

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Magnetic Microswarm Composed of Porous Nanocatalysts for Targeted Elimination of Biofilm Occlusion

ACS Nano, Journal Year: 2021, Volume and Issue: 15(3), P. 5056 - 5067

Published: Feb. 26, 2021

Biofilm is difficult to thoroughly cure with conventional antibiotics due the high mechanical stability and antimicrobial barrier resulting from extracellular polymeric substances. Encouraged by great potential of magnetic micro-/nanorobots in various fields their enhanced action swarm form, we designed a microswarm consisting porous Fe3O4 mesoparticles (p-Fe3O4 MPs) explored its application biofilm disruption. Here, p-Fe3O4 MPs swarm) was generated actuated simple rotating field, which exhibited capability remote actuation, cargo capacity, strong localized convections. Notably, could eliminate biofilms efficiency synergistic effects chemical physical processes: (i) generating bactericidal free radicals (•OH) for killing bacteria cells degrading MPs; (ii) physically disrupting promoting •OH penetration deep into motion. As demonstration targeted treatment, be clear along geometrical route on 2D surface sweep away clogs 3D U-shaped tube. This platform holds treating occlusions particularly inside tiny tortuous cavities medical industrial settings.

Language: Английский

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