Iron and copper: critical executioners of ferroptosis, cuproptosis and other forms of cell death

Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)

Published: Nov. 16, 2023

Abstract Regulated cell death (RCD) is a regulable that involves well-organized signaling cascades and molecular mechanisms. RCD implicated in fundamental processes such as organ production tissue remodeling, removing superfluous structures or cells, regulating numbers. Previous studies have not been able to reveal the complete mechanisms, novel methods of are constantly being proposed. Two metal ions, iron (Fe) copper (Cu) essential factors leading RCDs only induce ferroptosis cuproptosis, respectively but also lead impairment eventually diverse death. This review summarizes direct indirect mechanisms by which Fe Cu impede growth various forms mediated these two metals. Moreover, we aimed delineate interrelationships between with distinct pathways shedding light on complex intricate govern cellular survival Finally, prospects outlined this suggest approach for investigating death, may involve integrating current therapeutic strategies offer promising solution overcome drug resistance certain diseases.

Language: Английский

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Siderophore-Producing Rhizobacteria as a Promising Tool for Empowering Plants to Cope with Iron Limitation in Saline Soils: A Review

Pedosphere, Journal Year: 2019, Volume and Issue: 29(4), P. 409 - 420

Published: July 18, 2019

Language: Английский

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Recent advances in cation sensing using aggregation-induced emission

Materials Chemistry Frontiers, Journal Year: 2020, Volume and Issue: 5(2), P. 659 - 708

Published: Sept. 25, 2020

This review summarizes recent advances in AIE-based chemosensors for the detection of a wide range metal cations, outlining various sensing mechanisms and performances such as sensitivity selectivity chemosensors.

Language: Английский

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Iron metabolism and its contribution to cancer (Review)

International Journal of Oncology, Journal Year: 2019, Volume and Issue: unknown

Published: Feb. 20, 2019

Iron is an essential element for biological processes. homeostasis regulated through several mechanisms, from absorption by enterocytes to recycling macrophages and storage in hepatocytes. has dual properties, which may facilitate tumor growth or cell death. Cancer cells exhibit increased dependence on iron compared with normal cells. Macrophages potentially deliver cancer cells, resulting promotion. Mitochondria utilize cellular synthesize cofactors, including heme sulfur clusters. The latter composed of enzymes involved DNA synthesis repair, oxidation‑reduction reactions, other However, highly concentrations result death membrane lipid peroxidation, termed ferroptosis. Ferroptosis, emerging pathway treatment, similar pyroptosis, apoptosis necroptosis. In the present review, previous studies physiology metabolism its role are summarized. Additionally, significance regulation, association between carcinogenic mechanisms discussed.

Language: Английский

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Iron in the Tumor Microenvironment—Connecting the Dots

Frontiers in Oncology, Journal Year: 2018, Volume and Issue: 8

Published: Nov. 26, 2018

Iron metabolism and tumor biology are intimately linked. facilitates the production of oxygen radicals, which may either result in iron-induced cell death, ferroptosis, or contribute to mutagenicity malignant transformation. Once transformed, cells require high amounts iron for proliferation. In addition, has multiple regulatory effects on immune system, thus affecting surveillance by cells. For these reasons, inconsiderate supplementation cancer patients potential worsening disease course outcome. On other hand, chronic activation setting malignancy alters systemic homeostasis directs fluxes into myeloid While this response aims at withdrawing from cells, it impair effector functions tumor-associated macrophages will iron-restricted erythropoiesis development anemia, subsequently. This review summarizes our current knowledge interconnections with biology, discusses clinical controversies treatment anemia focuses roles solid microenvironment, also speculating yet unknown molecular mechanisms.

Language: Английский

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Evaluation of metal-based antimicrobial compounds for the treatment of bacterial pathogens

Journal of Medical Microbiology, Journal Year: 2021, Volume and Issue: 70(5)

Published: May 7, 2021

Antimicrobial resistance (AMR) is one of the greatest global health challenges modern times and its prevalence rising worldwide. AMR within bacteria reduces efficacy antibiotics increases both morbidity mortality associated with bacterial infections. Despite this growing risk, few a novel mode action are being produced, leading to lack that can effectively treat infections AMR. Metals have history antibacterial use but upon discovery antibiotics, often became overlooked as agents. Meanwhile, metal-based complexes been used treatments for other diseases, such gold-containing drug auranofin, rheumatoid arthritis. Metal-based compounds modes provide an advantage treatment conventional antibiotics. In review, activity, action, potential systemic number discussed. The current limitations these highlighted determine if agents solution infections, especially those resistant

Language: Английский

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Plant-Growth-Promoting Bacteria Mitigating Soil Salinity Stress in Plants

Applied Sciences, Journal Year: 2020, Volume and Issue: 10(20), P. 7326 - 7326

Published: Oct. 19, 2020

Soil deterioration has led to problems with the nutrition of world’s population. As one most serious stressors, soil salinization a negative effect on quantity and quality agricultural production, drawing attention need for environmentally friendly technologies overcome adverse effects. The use plant-growth-promoting bacteria (PGPB) can be key factor in reducing salinity stress plants as they are already introduced practice. Plants having halotolerant PGPB their root surroundings improve diverse morphological, physiological, biochemical aspects due multiple traits. These beneficial effects related excretion bacterial phytohormones modulation expression, improvement availability nutrients, release organic compounds that modify plant rhizosphere function signaling molecules, thus contributing plant’s tolerance. This review aims elucidate mechanisms by which able increase tolerance under salinity.

Language: Английский

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The Influence of Nutritional Factors on Immunological Outcomes

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: May 31, 2021

Through food intake, humans obtain a variety of nutrients that are essential for growth, cellular function, tissue development, energy, and immune defense. A special interaction between gut-associated lymphoid occurs in the intestinal tract. Enterocytes barrier act as sensors antigens from microbiota, which they deliver to underlying system lamina propria, triggering an response. Studies investigating mechanism influence nutrition on immunological outcomes have highlighted important role macronutrients (proteins, carbohydrates, fatty acids) micronutrients (vitamins, minerals, phytochemicals, antioxidants, probiotics) modulating homeostasis. Nutrients exert their innate immunity inflammation by regulating expression TLRs, pro- anti-inflammatory cytokines, thus interfering with cell crosstalk signaling. Chemical substrates derived nutrient metabolism may cofactors or blockers enzymatic activity, influencing molecular pathways chemical reactions associated microbial killing, inflammation, oxidative stress. Immune function appears be influenced certain form parts membrane structure involved energy production prevention cytotoxicity. also contribute initiation regulation adaptive responses B T lymphocyte differentiation, proliferation activation, antibody production. The purpose this review is present available data field nutritional immunology elucidate complex dynamic relationship system, delineation will lead optimized regimens disease patient care.

Language: Английский

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Iron homeostasis and organismal aging

Ageing Research Reviews, Journal Year: 2021, Volume and Issue: 72, P. 101510 - 101510

Published: Nov. 9, 2021

Language: Английский

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Comprehensive analysis of iron utilization by Mycobacterium tuberculosis

PLoS Pathogens, Journal Year: 2020, Volume and Issue: 16(2), P. e1008337 - e1008337

Published: Feb. 18, 2020

Iron is essential for nearly all bacterial pathogens, including Mycobacterium tuberculosis (Mtb), but severely limited in the human host. To meet its iron needs, Mtb secretes siderophores, small molecules with high affinity iron, and takes up iron-loaded mycobactins (MBT) carboxymycobactins (cMBT), from environment. also capable of utilizing heme hemoglobin which contain more than 70% body. However, many components these acquisition pathways are still unknown. In this study, a high-density transposon mutagenesis coupled deep sequencing (TnSeq) showed that exhibits opposite requirements 165 genes presence versus MBT cMBT as sources. The ESX-3 secretion system was assessed siderophore-mediated uptake and, surprisingly, utilization by Mtb. Predictions derived TnSeq analysis were validated growth experiments isogenic mutants. These results (i) efflux pump MmpL5 plays dominant role siderophore secretion, (ii) Rv2047c protein mycobactin, (iii) transcriptional repressor Zur required novel genetic determinants revealed study will stimulate further important area physiology.

Language: Английский

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