Lasers in Medical Science,
Journal Year:
2025,
Volume and Issue:
40(1)
Published: Feb. 15, 2025
Abstract
Human
umbilical
cord
matrix
Wharton’s
jelly
mesenchymal
stem
cells
(WJ-MSCs)
are
commonly
utilized
in
regenerative
medicine
due
to
their
therapeutic
benefits.
However,
the
microenvironmental
stress
present
patients
with
hyperglycemia
can
significantly
reduce
cell
(MSC)
viability
under
high-glucose
conditions
body,
ultimately
reducing
effectiveness.
Enhancing
survival
rate
of
MSCs
following
transplantation
remains
a
crucial
challenge.
This
study
investigates
whether
Quantum
Hyperlight
(QHL)
counteract
detrimental
effects
high
glucose
(HG),
thereby
improving
MSC
survival,
proliferation,
and
mitochondrial
function.
We
aimed
evaluate
effect
QHL
on
cellular
viability,
activity
WJ-MSCs
exposed
HG.
were
cultured
medium
containing
normal
(NG)
(1
g/L)
HG
(4.5
g/L).
for
90
s
or
180
an
energy
density
2.4
Joules/cm
2
/minute
average
power
40
mW/cm
.
Then,
proliferating
nuclear
antigen
(PCNA),
MTT
assays,
Mitotracker
Green
staining
performed
proliferation.
The
was
increased
QHL-treated
groups
(84%
QHL-90
86%
QHL-180
s)
compared
untreated
group
(65%,
p
<
0.001).
PCNA
expression
showed
significant
increases
(
0.001)
group.
MitoTracker
intensity
higher
environment
reduced
staining.
In
context
NG
environment,
exhibited
notable
differences.
rates
when
treated
that
did
not
receive
QHL.
introduces
as
novel
approach
enhance
potential
conditions,
demonstrating
its
ability
improve
activity.
highlights
pretreatment
clinical
outcomes
medicine.
Materials Advances,
Journal Year:
2021,
Volume and Issue:
2(6), P. 1821 - 1871
Published: Jan. 1, 2021
Nanomaterials
have
emerged
as
an
amazing
class
of
materials
that
consists
a
broad
spectrum
examples
with
at
least
one
dimension
in
the
range
1
to
100
nm.
Pharmaceutics,
Journal Year:
2020,
Volume and Issue:
12(4), P. 371 - 371
Published: April 17, 2020
Nanoparticles
(NPs)
and
submicron
particles
are
increasingly
used
as
carriers
for
delivering
therapeutic
compounds
to
cells.
Their
entry
into
the
cell
represents
initial
step
in
this
delivery
process,
being
most
of
nanoparticles
taken
up
by
endocytosis,
although
other
mechanisms
can
contribute
uptake.
To
increase
efficiency
NPs
is
very
relevant
understand
involved
uptake
process.
This
review
covers
proposed
pathways
cellular
different
types
well
role
that
some
physicochemical
nanoparticle
characteristics
play
pathway
preferentially
gain
access
deliver
their
cargo
inside
cell.
Chemical Society Reviews,
Journal Year:
2018,
Volume and Issue:
47(11), P. 4198 - 4232
Published: Jan. 1, 2018
This
review
summarizes
the
latest
developments
and
addresses
current
applications
future
perspectives
of
carbon-based
hybrid
nanogels
in
biomedical
field.
Journal of Materials Chemistry B,
Journal Year:
2017,
Volume and Issue:
5(48), P. 9452 - 9476
Published: Jan. 1, 2017
Organ
ischemia
with
inadequate
oxygen
supply
followed
by
reperfusion
(which
initiates
a
complex
of
inflammatory
responses
and
oxidative
stress)
occurs
in
different
clinical
conditions
surgical
procedures
including
stroke,
myocardial
infarction,
limb
ischemia,
renal
failure,
organ
transplantation,
free-tissue-transfer,
cardiopulmonary
bypass,
vascular
surgery.
Even
though
pharmacological
treatments
protect
against
experimental
(I/R)
injury,
there
has
not
been
enough
success
their
application
for
patient
benefits.
The
main
hurdles
the
treatment
I/R
injury
are
lack
diagnosis
tools
understanding
complicated
chains
I/R-induced
signaling
events,
especially
acute
phase
after
determining
affected
regions
tissue
over
time,
then,
targeting
safe
delivery
antioxidants,
drugs,
peptides,
genes
cells
to
areas
requiring
treatment.
Besides
innate
antioxidant
free
radical
scavenging
properties,
some
nanoparticles
also
show
higher
flexibility
drug
imaging.
This
review
highlights
three
approaches
nanoparticle-mediated
injury:
(1)
as
antioxidants
reducing
stress,
(2)
targeted
therapeutic
agents
ischemic
or
cells,
(3)
imaging
at
molecular,
cellular
level
monitoring
its
evolution
using
contrasts
induced
nanoparticles.
These
can
be
combined
realize
so
called
theranostics
providing
simultaneous
delivery.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(18)
Published: April 25, 2023
Carbon-based
nanomaterials,
including
graphene,
fullerenes,
and
carbon
nanotubes,
are
attracting
significant
attention
as
promising
materials
for
next-generation
energy
storage
conversion
applications.
They
possess
unique
physicochemical
properties,
such
structural
stability
flexibility,
high
porosity,
tunable
features,
which
render
them
well
suited
in
these
hot
research
fields.
Technological
advances
at
atomic
electronic
levels
crucial
developing
more
efficient
durable
devices.
This
comprehensive
review
provides
a
state-of-the-art
overview
of
advanced
carbon-based
nanomaterials
various
applications,
focusing
on
supercapacitors,
lithium
sodium-ion
batteries,
hydrogen
evolution
reactions.
Particular
emphasis
is
placed
the
strategies
employed
to
enhance
performance
through
nonmetallic
elemental
doping
N,
B,
S,
P
either
individual
or
codoping,
modifications
creation
defect
sites,
edge
functionalization,
inter-layer
distance
manipulation,
aiming
provide
general
guidelines
designing
devices
by
above
approaches
achieve
optimal
performance.
Furthermore,
this
delves
into
challenges
future
prospects
advancement
electrodes
conversion.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(5), P. 8069 - 8086
Published: April 7, 2021
Therapeutic
options
for
the
highly
pathogenic
human
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
causing
current
pandemic
disease
(COVID-19)
are
urgently
needed.
COVID-19
is
associated
with
viral
pneumonia
and
distress
significant
morbidity
mortality.
The
proposed
treatments
have
shown
little
or
no
effect
in
clinic
so
far.
Additionally,
bacterial
fungal
pathogens
contribute
to
SARS-CoV-2-mediated
complex.
antibiotic
resistance
treatment
increasing
at
an
alarming
rate.
Therefore,
carbon-based
nanomaterials
(CBNs),
such
as
fullerene,
carbon
dots,
graphene,
their
derivatives
constitute
a
promising
alternative
due
wide-spectrum
antimicrobial
activity,
biocompatibility,
biodegradability,
capacity
induce
tissue
regeneration.
Furthermore,
mode
of
action
mainly
physical
(e.g.,
membrane
distortion),
characterized
by
low
risk
resistance.
In
this
Review,
we
evaluated
literature
on
antiviral
activity
broad-spectrum
properties
CBNs.
CBNs
had
against
13
enveloped
positive-sense
single-stranded
RNA
viruses,
including
SARS-CoV-2.
toxicity
humans
therapeutics
complex
other
bacteria,
fungi,
those
that
multidrug-resistant.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(22), P. 12371 - 12430
Published: Aug. 24, 2023
Nowadays,
the
increasing
emergence
of
antibiotic-resistant
pathogenic
microorganisms
requires
search
for
alternative
methods
that
do
not
cause
drug
resistance.
Phototherapy
strategies
(PTs)
based
on
photoresponsive
materials
have
become
a
new
trend
in
inactivation
due
to
their
spatiotemporal
controllability
and
negligible
side
effects.
Among
those
phototherapy
strategies,
photocatalytic
antimicrobial
therapy
(PCAT)
has
emerged
as
an
effective
promising
strategy
recent
years.
In
process
treatment,
are
excited
by
different
wavelengths
lights
produce
reactive
oxygen
species
(ROS)
or
other
toxic
killing
various
microbes,
such
bacteria,
viruses,
fungi,
parasites,
algae.
Therefore,
this
review
timely
summarizes
latest
progress
PCAT
field,
with
emphasis
development
antimicrobials
(PCAMs),
underlying
mechanisms,
design
multiple
practical
applications
local
infections
therapy,
personal
protective
equipment,
water
purification,
coatings,
wound
dressings,
food
safety,
antibacterial
textiles,
air
purification.
Meanwhile,
we
also
present
challenges
perspectives
widespread
implementation
therapeutics.
We
hope
result
review,
will
flourish
weapon
against
antibiotic
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(18), P. 11047 - 11136
Published: Sept. 7, 2023
Advances
in
nanotechnology
and
nanomaterials
have
attracted
considerable
interest
play
key
roles
scientific
innovations
diverse
fields.
In
particular,
increased
attention
has
been
focused
on
carbon-based
exhibiting
extended
structures
unique
properties.
Among
these
materials,
zero-dimensional
structures,
including
fullerenes,
carbon
nano-onions,
nanodiamonds,
dots,
possess
excellent
bioaffinities
superior
fluorescence
properties
that
make
suitable
for
application
to
environmental
biological
sensing,
imaging,
therapeutics.
This
review
provides
a
systematic
overview
of
the
classification
structural
properties,
design
principles
preparation
methods,
optical
sensing
applications
nanomaterials.
Recent
interesting
breakthroughs
sensitive
selective
imaging
heavy
metal
pollutants,
hazardous
substances,
bioactive
molecules
as
well
information
encryption,
super-resolution
photoacoustic
phototherapy
nanomedicine
delivery
are
main
focus
this
review.
Finally,
future
challenges
prospects
materials
highlighted
envisaged.
presents
comprehensive
basis
directions
designing,
developing,
applying
fascinating
fluorescent
sensors
fabricated
based
specific
requirements
numerous
research
