Frontiers in Chemistry,
Journal Year:
2019,
Volume and Issue:
7
Published: Feb. 22, 2019
Near-infrared
(12,500-4000
cm-1;
800-2500
nm)
spectroscopy
bears
the
hallmark
of
being
one
most
rapidly
advancing
analytical
techniques
over
last
few
decades.
Although
it
is
mainly
recognized
as
an
tool,
near-infrared
also
has
a
significant
contribution
to
physical
chemistry,
e.g.
by
delivering
invaluable
data
on
anharmonic
nature
molecular
vibrations
or
peculiarities
intermolecular
interactions.
In
all
these
contexts
often
encountered
major
barrier
in
form
intrinsic
complexity
spectra.
Large
number
overlapping
vibrational
contributions
influenced
effects
create
complex
patterns
spectral
dependencies
many
cases
hindering
our
comprehension
Quantum
mechanical
calculations
commonly
deliver
support
infrared
and
Raman
studies;
conversely,
long
been
hindered
this
regard
due
practical
limitations.
Advances
theories
hyphenation
with
ever-growing
computer
technology
have
enabled
feasible
theoretical
recent
time.
Accordingly,
witnessed
growing
quantum
investigations
aimed
at
region.
The
present
review
article
summarizes
accomplishments
emerging
field.
Applications
generalized
approaches
such
self-consistent
field
second
order
perturbation
well
their
derivatives,
dense
grid-based
studies
potential
are
overviewed.
Basic
applied
discussed
special
attention
paid
ones
which
aim
improving
spectroscopy.
A
remarkable
arises
from
applicability
computations
solving
problems
arise
both
basic
highlights
increased
value
relation
other
kinds
Advanced Functional Materials,
Journal Year:
2019,
Volume and Issue:
30(7)
Published: Dec. 18, 2019
Abstract
The
shortage
of
high
quantum
yield
(QY)
organic
fluorophores
in
the
second
near‐infrared
window
(NIR‐II)
has
become
a
bottleneck
bioimaging
field.
Now,
simple
strategy
is
proposed
to
address
this:
constitutional
isomerization
on
basis
molecular
design
philosophy
aggregation‐induced
emission.
With
combination
backbone
distortion
and
rotor
twisting,
resultant
NIR‐II
fluorophore
2TT‐
o
C6B
displays
an
emission
peak
at
1030
nm
QY
11%
nanoparticles,
one
highest
reported
so
far.
Control
molecules
confirm
that
distorted
twisted
rotors
play
equally
important
roles
determining
fluorescence
properties
fluorophores.
To
allow
for
targeting
ability
reach
deeply
located
diseases,
neutrophils
(NEs)
are
used
penetrate
brain
tissues
accumulate
inflammation
site.
Herein,
it
shown
NEs
carrying
nanoparticles
can
blood‐brain‐barrier
visualize
through
intact
scalp
skull.
Notably,
bright
contributes
significantly
enhanced
signal‐to‐background
ratio
30.6
Chemical Science,
Journal Year:
2020,
Volume and Issue:
12(10), P. 3427 - 3436
Published: June 12, 2020
Aggregation-induced
emission
(AIE)
is
a
cutting-edge
fluorescence
technology,
giving
highly-efficient
solid-state
photoluminescence.
Particularly,
AIE
luminogens
(AIEgens)
with
in
the
range
of
second
near-infrared
window
(NIR-II,
1000-1700
nm)
have
displayed
salient
advantages
for
biomedical
imaging
and
therapy.
However,
molecular
design
strategy
underlying
mechanism
regulating
balance
between
(radiative
pathway)
photothermal
effect
(non-radiative
these
narrow
bandgap
materials
remain
obscure.
In
this
review,
we
outline
latest
achievements
guidelines
photophysical
process
control
developing
highly
efficient
NIR-II
emitters
or
agents
aggregation-induced
attributes.
We
provide
insights
to
optimize
efficiency
by
multi-hierarchical
structures
from
single
molecules
(flexibilization)
aggregates
(rigidification).
also
discuss
crucial
role
intramolecular
motions
balancing
functions
The
superiority
region
demonstrated
fluorescence/photoacoustic
blood
vessels
brain
as
well
ablation
tumor.
Finally,
summary
challenges
perspectives
AIEgens
