Recent Development of Halide Perovskite Materials and Devices for Ionizing Radiation Detection

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(4), P. 1207 - 1261

Published: Feb. 2, 2023

Ionizing radiation such as X-rays and γ-rays has been extensively studied used in various fields medical imaging, radiographic nondestructive testing, nuclear defense, homeland security, scientific research. Therefore, the detection of high-energy with high-sensitivity low-cost-based materials devices is highly important desirable. Halide perovskites have emerged promising candidates for due to large light absorption coefficient, resistivity, low leakage current, high mobility, simplicity synthesis processing compared commercial silicon (Si) amorphous selenium (

Language: Английский

---

Cancer therapeutics based on diverse energy sources

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(19), P. 8201 - 8215

Published: Jan. 1, 2022

Light has been utilized for cancer treatment owing to its advantages. Low penetration depth of light restricts application in treatment. To overcome the drawback, various treatments based on each energy sources have developed.

Language: Английский

---

Advancing X-ray Luminescence for Imaging, Biosensing, and Theragnostics

Accounts of Chemical Research, Journal Year: 2022, Volume and Issue: 56(1), P. 37 - 51

Published: Dec. 19, 2022

X-ray luminescence is an optical phenomenon in which chemical compounds known as scintillators can emit short-wavelength light upon the excitation of photons. Since X-rays exhibit well-recognized advantages deep penetration toward tissues and a minimal autofluorescence background biological samples, has been increasingly becoming promising tool for tackling challenges fields imaging, biosensing, theragnostics. In recent years, emergence nanocrystal have further expanded application scenarios luminescence, such high-resolution autofluorescence-free detection biomarkers, noninvasive phototherapy tissues. Meanwhile, holds great promise breaking depth dependency deep-seated lesion treatment achieving synergistic radiotherapy with phototherapy.In this Account, we provide overview advances developing advanced applications theragnostics, optogenetics neuromodulation. We first introduce solution-processed lead halide all-inorganic perovskite that are able to convert photons multicolor luminescence. developed nanoscintillator-based detector imaging internal structure electronic circuits samples. development flexible using solution-processable lanthanide-doped nanoscintillators featuring long-lived image three-dimensional irregularly shaped objects. also outline general principles high-contrast vivo combines functional biomolecules aptamers, peptides, antibodies. High-quality nanoprobes were engineered achieve high-sensitivity various enabled avoidance interference from matrix photon scattering. By marrying probes stimuli-responsive materials, multifunctional theragnostic nanosystems constructed on-demand gas excellent therapeutic effects. taking advantage capability penetrate skull, demonstrated controllable, wireless optogenetic neuromodulation while obviating damage traditional fibers. Furthermore, discussed detail some future terms scintillator synthesis surface modification, mechanism studies, their other potential useful guidance advancing

Language: Английский

---

Recent Progress and Trends in X-ray-Induced Photodynamic Therapy with Low Radiation Doses

ACS Nano, Journal Year: 2022, Volume and Issue: 16(12), P. 19691 - 19721

Published: Nov. 15, 2022

The prominence of photodynamic therapy (PDT) in treating superficial skin cancer inspires innovative solutions for its congenitally deficient shadow penetration the visible-light excitation. X-ray-induced (X-PDT) has been proven to be a successful technique reforming conventional PDT deep-seated tumors by creatively utilizing penetrating X-rays as external excitation sources and witnessed rapid developments over past several years. Beyond proof-of-concept demonstration, recent advances X-PDT have exhibited trend minimizing X-ray radiation doses quite low values. As such, scintillating materials used bridge photosensitizers play significant role, do diverse well-designed irradiation modes smart strategies improving tumor microenvironment. Here this review, we provide comprehensive summary achievements highlight trending efforts using radiation. We first describe concept relationships with radiodynamic radiotherapy then dissect mechanism absorption conversion materials, reactive oxygen species evaluation X-PDT, side effects clinical concerns on Finally, discuss detailed overview progress regarding low-dose present perspectives possible translation. It is expected that pursuit will facilitate breakthroughs, both fundamentally clinically, effective treatment near future.

Language: Английский

---

Engineered Bacteria for Enhanced Radiotherapy against Breast Carcinoma

ACS Nano, Journal Year: 2022, Volume and Issue: 16(1), P. 801 - 812

Published: Jan. 14, 2022

Radiotherapy is widely applied for multiple malignant tumors ablation in the clinic. However, redundant doses of X-rays might destroy normal tissue periphery tumor sites. Here, we developed an integrated nanosystem (Bac@BNP) composed engineered bacteria (Bac) and Bi2S3 nanoparticles (BNPs) sensitizing radiotherapy. Bac could target colonize sites alternatively, which overexpressed cytolysin A (ClyA) protein to regulate cell cycle from a radioresistant phase radiosensitive phase. Simultaneously, peptide-modified BNPs, as radiosensitizer with high-Z element, was released surface owing matrix metalloproteinase-2 (MMP-2) response microenvironment. Under X-ray irradiation, BNPs enhance radiotherapy sensitivity by triggering intracellular generation reactive oxygen species (ROS), coupled DNA damage. In this constructed nanosystem, combination Bac@BNP irradiation led significant suppression breast carcinoma murine models reduced side effects.

Language: Английский

---