Chinese Journal of Chemistry,
Journal Year:
2021,
Volume and Issue:
39(10), P. 2781 - 2788
Published: June 27, 2021
Main
observation
and
conclusion
In
this
article,
we
report
a
base‐promoted
sequential
cyclization/aldol‐type
condensation/isomerization
cascade
reaction
of
N
‐propargyl‐β‐enaminones
with
aryl
aldehydes.
The
key
step
in
protocol
is
the
generation
1,4‐oxazepine
anions
from
under
basic
conditions,
which
are
captured
by
method
allows
formation
one
pyridone
core
C—C
double
bond
“one
pot”,
preparation
variety
densely
decorated
derivatives
moderate
to
good
yields
broad
functional
group
tolerance.
Green Chemistry,
Journal Year:
2019,
Volume and Issue:
22(1), P. 118 - 122
Published: Nov. 29, 2019
A
practical
method
for
the
clean
preparation
of
multisubstituted
pyrroles
via
an
iodine-catalyzed
multicomponent
reaction
under
metal-
and
solvent-free
conditions
was
developed.
In
gram-scale
synthesis,
can
be
easily
collected
through
simple
extraction.
Chemical Science,
Journal Year:
2019,
Volume and Issue:
10(39), P. 9104 - 9108
Published: Jan. 1, 2019
Highly
chemoselective
Ru(ii)-catalyzed
deacylative
annulation
of
1,3-diones
with
sulfoxonium
ylides
was
achieved
to
afford
(hetero)aryl
substituted
furans.
The Journal of Organic Chemistry,
Journal Year:
2019,
Volume and Issue:
85(2), P. 1216 - 1223
Published: Dec. 6, 2019
A
ruthenium(II)-catalyzed
annulation
between
two
molecules
of
sulfoxonium
ylides
is
achieved,
generating
a
variety
substituted
isocoumarins
in
reasonable
yields.
This
strategy
features
dual
C–H/C–C
activation
one
pot
and
has
wide
substrate
scope
good
functional
group
tolerance.
Chemical Communications,
Journal Year:
2021,
Volume and Issue:
57(72), P. 9112 - 9115
Published: Jan. 1, 2021
The
C–N
bond
cyanation
of
tertiary
enaminones
has
been
realized
for
the
stereoselective
synthesis
both
(
E
)-
and
Z
)-β-cyano
enones
under
mild
metal-free
conditions,
providing
highly
practical
approaches
β-cyano
enones.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 19, 2025
A
rhodium-catalyzed
annulation
of
2H-azirines
with
enaminones
is
presented.
This
protocol
affords
a
convenient
approach
to
the
diversity-oriented
synthesis
4-acyl-
and
4-formyl
pyrroles
good
functional
group
tolerance.
The
utility
this
reaction
has
been
demonstrated
by
scale-up
preparation,
late-stage
modification
natural
molecules,
diverse
derivatives.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 10, 2025
Compared
with
the
well-developed
cyclization
of
functionalized
propargylamines,
use
unactivated
tertiary
propargylamines
to
access
pyrroles
remains
challenging.
Herein,
we
report
an
efficient
method
for
constructing
tetrasubstituted
via
a
DBU-mediated
intramolecular
cycloaddition
N-alkyl
propargylamines.
This
reaction
employs
dihydropyrrole
intermediates,
followed
by
oxidation
produce
in
presence
2,3-dichloro-5,6-dicyano-p-benzoquinone.
In
addition,
broad
substrate
scope,
high
atom
economy,
selectivity,
and
simple
operation
are
also
advantages
this
protocol.
Organic Letters,
Journal Year:
2019,
Volume and Issue:
21(21), P. 8603 - 8606
Published: Oct. 15, 2019
We
report
a
highly
efficient
copper-catalyzed
three-component
reaction
of
alkylamines,
acetylenedicarboxylates,
and
α-bromocarbonyls
for
the
assembly
fully
substituted
1,3-dihydro-2H-pyrrol-2-ones.
A
variety
alkylamines
ammonium
salt
are
functionalized
with
acetylenedicarboxylates
α-bromocarbonyls.
N-aryl
enaminoesters
also
successfully
alkylated
This
protocol
is
understood
to
proceed
through
radical
Heck-type
coupling
in-situ-generated
bulky
trisubstituted
alkenes
tertiary
alkyl
bromides,
which
realized
first
time.
Chemistry - A European Journal,
Journal Year:
2019,
Volume and Issue:
26(9), P. 1941 - 1946
Published: Dec. 23, 2019
Abstract
Compared
with
the
ripeness
of
olefin
metathesis,
exploration
construction
carbon–carbon
double
bonds
through
catalytic
carbonyl–olefin
metathesis
reaction
remains
stagnant
and
has
received
scant
attention.
Herein,
a
highly
efficient
AuCl
3
‐catalyzed
intramolecular
ring‐closing
is
described.
This
method
features
easily
accessible
starting
materials,
simple
operation,
good
functional‐group
tolerance
short
times,
provides
target
cyclopentenes,
polycycles,
benzocarbocycles,
N‐heterocycle
derivatives
in
to
excellent
yields.
Chemical Communications,
Journal Year:
2020,
Volume and Issue:
56(29), P. 4078 - 4081
Published: Jan. 1, 2020
A
novel
method
for
the
synthesis
of
3-(2-quinolyl)
chromones
through
a
tandem
[3+2]
cycloaddition/ring-opening/O-arylation
from
ynones
and
quinoline
N-oxides
has
been
developed.
This
protocol
proceeds
under
transition
metal-
additive-free
conditions
can
be
amplified
to
gram
level
in
91%
yield.
3-(1-Isoquinolyl)
3-(2-pyridyl)
are
also
successfully
synthesized
using
isoquinoline
pyridine
basic
conditions.
Various
heteroarene-contaning
were
afforded
30-98%
yields,
which
difficult
obtained
compounds
interest
pharmaceutical
chemistry
chemical
biology.
