Advanced Synthesis & Catalysis,
Journal Year:
2022,
Volume and Issue:
364(7), P. 1319 - 1325
Published: Feb. 23, 2022
Abstract
An
atom
and
step
economy
cascade
trifluoromethylation/cyclization
of
unactivated
alkene
with
Langlois
reagent
as
a
CF
3
source
is
described.
A
variety
polycyclic
quinazolinones
were
successfully
synthesized
in
52–81%
yields
under
transition
metal‐
oxidant‐free
conditions.
The
used
this
strategy
possesses
the
advantages
bench‐stablity,
cost‐effectivity
high‐efficiency.
Additionally,
gram‐scale
reaction,
broad
substrate
scope
good
functional
group
tolerance
demonstrated
synthetic
usefulness
protocol.
magnified
image
Angewandte Chemie International Edition,
Journal Year:
2019,
Volume and Issue:
58(14), P. 4700 - 4704
Published: Jan. 30, 2019
Abstract
In
oxidative
electrochemical
organic
synthesis,
radical
intermediates
are
often
oxidized
to
cations
on
the
way
final
product
formation.
Herein,
we
describe
an
approach
transform
electrochemically
generated
into
neutral
products
by
reaction
with
a
metal
catalyst.
This
combines
oxidation
Cu
catalysis
effect
formal
aza‐Wacker
cyclization
of
internal
alkenes.
The
catalyst
is
essential
for
transforming
secondary
and
primary
alkyl
A
wide
range
5‐membered
N‐heterocycles
including
oxazolidinone,
imidazolidinone,
thiazolidinone,
pyrrolidinone,
isoindolinone
can
be
prepared
under
mild
conditions.
The Chemical Record,
Journal Year:
2021,
Volume and Issue:
21(9), P. 2290 - 2305
Published: March 16, 2021
Abstract
Organic
electrosynthesis
has
gained
increasing
research
interest
as
it
harvests
electric
current
redox
regents,
thereby
providing
a
sustainable
alternative
to
conventional
approaches.
Compared
with
direct
electrosynthesis,
indirect
employs
mediator(s)
lower
the
overpotentials
for
substrate
activation,
and
enhance
reaction
efficiency
functional
group
compatibility
by
shifting
heterogenous
electron
transfer
process
be
homogenous.
As
one
of
most
versatile
cost‐efficient
mediators,
halogen
mediators
are
always
combined
an
irreversible
halogenation
reaction.
Thus,
electrochemical
between
substrates
doesn't
directly
controlled
two
standard
potentials
difference.
In
this
account,
our
recent
developments
in
area
halogen‐mediated
summarized.
The
anodically
generated
species
from
halogenide
salts
have
abilities
undergo
electron‐transfer
(ET)
or
hydrogen‐atom‐
(HAT)
processes.
features,
scopes,
limitations,
mechanistic
rationalisations
discussed
account.
We
hope
studies
will
contribute
future
broaden
scope
electrosynthesis.
Green Chemistry,
Journal Year:
2020,
Volume and Issue:
22(5), P. 1548 - 1552
Published: Jan. 1, 2020
Cobalt
catalyzed
electrochemical
[4
+
2]
annulation
of
sulfonamides
with
alkynes
is
demonstrated
in
this
work,
which
provided
a
practical
and
environmentally
friendly
way
to
synthesize
structurally
diverse
sultams.
The Chemical Record,
Journal Year:
2021,
Volume and Issue:
21(9), P. 2502 - 2525
Published: June 21, 2021
Abstract
Electrosynthesis
can
be
considered
a
powerful
and
sustainable
methodology
for
the
synthesis
of
small
organic
molecules.
Due
to
its
intrinsic
ability
generate
highly
reactive
species
under
mild
conditions
by
anodic
oxidation
or
cathodic
reduction,
electrosynthesis
is
particularly
interesting
otherwise
challenging
transformations.
One
such
challenge
installation
fluorinated
alkyl
groups,
which
has
gained
significant
attention
in
medicinal
chemistry
material
science
due
their
unique
physicochemical
features.
Unsurprisingly,
several
electrochemical
fluoroalkylation
methods
have
been
established.
In
this
review,
we
survey
recent
developments
established
field
mono‐,
di‐,
trifluoromethylation,
perfluoroalkylation
Advanced Synthesis & Catalysis,
Journal Year:
2022,
Volume and Issue:
364(7), P. 1319 - 1325
Published: Feb. 23, 2022
Abstract
An
atom
and
step
economy
cascade
trifluoromethylation/cyclization
of
unactivated
alkene
with
Langlois
reagent
as
a
CF
3
source
is
described.
A
variety
polycyclic
quinazolinones
were
successfully
synthesized
in
52–81%
yields
under
transition
metal‐
oxidant‐free
conditions.
The
used
this
strategy
possesses
the
advantages
bench‐stablity,
cost‐effectivity
high‐efficiency.
Additionally,
gram‐scale
reaction,
broad
substrate
scope
good
functional
group
tolerance
demonstrated
synthetic
usefulness
protocol.
magnified
image
