RSC Advances,
Journal Year:
2021,
Volume and Issue:
12(2), P. 692 - 697
Published: Dec. 23, 2021
A
novel
copper-catalyzed
thioetherification
reaction
has
been
developed
to
afford
benzyl
thioethers
in
moderate
excellent
yields.
Under
the
mild
and
easy-to-operate
conditions,
a
variety
of
are
efficiently
prepared
from
readily
available
alcohols
(primary,
secondary,
tertiary)
thiols
presence
Cu(OTf)2
as
Lewis
acid
catalysis.
This
C-S
bond
formation
protocol
furnishes
exceptional
chemoselectivity,
preliminary
mechanism
studies
show
that
should
proceed
through
Lewis-acid-mediated
SN1-type
nucleophilic
attack
carbocations
formed
situ.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(9), P. 5864 - 5871
Published: Feb. 20, 2024
Sulfur,
alongside
oxygen
and
nitrogen,
holds
a
prominent
position
as
one
of
the
key
heteroatoms
in
nature
medicinal
chemistry.
Its
significance
stems
from
its
ability
to
adopt
different
oxidation
states,
rendering
it
valuable
both
polarity
handle
hydrogen
bond
donor/acceptor.
Nevertheless,
poisonous
free
electron
pairs
makes
sulfur
containing
substrates
inaccessible
for
many
catalytic
protocols.
Strong
(at
low
temperatures)
irreversible
chemisorption
catalyst's
surface
is
particular
detrimental
heterogeneous
catalysts,
possessing
only
few
catalytically
active
sites.
Herein,
we
present
novel
Ru-S
catalyst
that
tolerates
multiple
functionalities,
including
thioethers,
thiophenes,
sulfoxides,
sulfones,
sulfonamides,
sulfoximines,
hydrogenation
quinolines.
The
utility
products
was
further
demonstrated
by
subsequent
diversifications
functionalities.
Russian Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
92(12), P. RCR5104 - RCR5104
Published: Dec. 1, 2023
After
the
appearance
of
green
chemistry
concept,
which
was
introduced
in
vocabulary
early
1990s,
its
main
statements
have
been
continuously
developed
and
modified.
Currently,
there
are
10–12
cornerstones
that
should
form
basis
for
an
ideal
chemical
process.
This
review
analyzes
accumulated
experience
achievements
towards
design
products
processes
reduce
or
eliminate
use
generation
hazardous
substances.
The
presents
views
leading
Russian
scientists
specializing
various
fields
this
subject,
including
homogeneous
heterogeneous
catalysis,
fine
basic
organic
synthesis,
electrochemistry,
polymer
chemistry,
based
on
bio-renewable
feedstocks
energetic
compounds
materials.
A
new
approach
to
quantitative
evaluation
environmental
friendliness
by
authors
is
described.
<br>
bibliography
includes
1761.
ACS Catalysis,
Journal Year:
2021,
Volume and Issue:
11(16), P. 10377 - 10382
Published: Aug. 5, 2021
An
example
of
homogeneous
Mo-catalyzed
direct
N-alkylation
anilines
or
nitroarenes
with
alcohols
is
presented.
The
DFT
aimed
design
suggested
the
easily
accessible
bis-NHC-Mo(0)
complex
features
a
strong
hydride-donating
ability,
achieving
effective
challenging
alcohols.
enhanced
strategy
should
be
useful
in
designing
highly
active
systems
for
borrowing
hydrogen
transformations.
The Journal of Organic Chemistry,
Journal Year:
2021,
Volume and Issue:
86(2), P. 1516 - 1527
Published: Jan. 7, 2021
A
simple
and
efficient
method
for
the
regioselective
thiolation
of
p-quinone
methides
with
sodium
aryl/alkyl
sulfinates
has
been
established
using
an
acid/phosphine-induced
radical
route
under
transition-metal-free
conditions.
broad
range
(p-QMs)
are
compatible
reaction,
giving
expected
products
good
to
excellent
yields.
Control
experiments
were
also
performed
gain
insights
into
generation
mechanism
thiyl
radicals
hydrogen-atom
transfer
process.
This
protocol
provides
a
safe
feasible
way
formation
carbon–sulfur
bonds.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 22, 2025
The
C–S
bond
is
of
significant
importance
due
to
its
unique
properties
and
diverse
roles
in
chemistry,
biology,
materials
science.
In
this
work,
we
present
an
efficient
synthetic
protocol
a
rapidly
dehydrative
coupling
reaction
with
alcohols
thiols
water
catalyzed
by
triaryl-carbenium
ion
pair.
Under
metal-free
conditions,
wide
range
thioethers
were
obtained
good
yields
(up
99%)
excellent
functional
group
tolerance,
including
the
fast
modification
amino
acid
derivatives
molecules.
This
method
allowed
reactions
be
conducted
low
catalyst
loading,
down
1.0
mol
%,
was
practical
for
gram-scale
synthesis.
Furthermore,
performed
under
biocompatible
making
approach
highly
suitable
potential
bioconjugation.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(13), P. 9450 - 9461
Published: June 13, 2024
Visible-light-promoted
thiolation
of
benzyl
chlorides
with
thiosulfonates
is
disclosed
via
an
electron
donor-acceptor
complex
strategy.
In
addition
to
efficiently
delivering
a
series
arylbenzylsulfide
compounds,
versatile
thioglycosides
were
also
successfully
constructed
by
applying
the
metal-
and
photocatalyst-free
protocol.
Preliminary
mechanistic
studies
suggest
that
radical-radical
coupling
process
was
involved
in
this
transformation.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 8, 2025
An
efficient
dehydroxythiolation
between
alcohols
and
disulfides
using
the
widely
abundant
cheapest
iron
as
a
reaction
mediator
was
developed.
The
one-pot
thiolation
proceeded
effectively
via
C-O
bond
activation
with
aid
of
cyanuric
chloride
(TCT)
hydroxyl-activating
agent
to
give
corresponding
thioethers
in
modest
excellent
yields,
displaying
both
wide
substrate
scope
(applicable
benzyl
alcohol,
allyl
primary
alkyl
alcohol)
good
functional
group
tolerance.
In
addition,
diselenide
also
proven
be
an
appropriate
for
protocol,
could
subjected
scale-up
synthesis.
Preliminary
mechanistic
examination
revealed
that
transiently
formed
TCT-derived
ether
A,
which
is
generated
situ
TCT
possibly
serves
pivotal
intermediate
cross-electrophile
thioetherification.
