An Investigation into the Intrinsic Peroxidase‐Like Activity of Fe‐MOFs and Fe‐MOFs/Polymer Composites DOI
Bhawana Thakur, Vikram V. Karve, Daniel T. Sun

et al.

Advanced Materials Technologies, Journal Year: 2021, Volume and Issue: 6(5)

Published: March 24, 2021

Abstract The quest for developing materials that provide a perfect trade‐off between factors such as enzyme‐like response, stability, and low cost has been long‐standing challenge in the field of biosensing. Metal‐organic frameworks (MOFs) their composites have emerged promising candidates biosensing applications due to exceptional properties tunable pore size, high specific surface area, exposed active sites. A comparative study intrinsic peroxidase‐like activity five different MOF materials: Fe‐BTC, NH 2 ‐MIL‐101(Fe), Fe‐BTC with polymers polydopamine (PDA), poly p‐phenylenediamine (PpPDA), poly(3,4‐ethylenedioxythiophene) is reported detection H O , an important biomarker biomedical diagnostics. response these toward via electrochemical colorimetric techniques mapped it found that, at neutral pH, Fe‐BTC/PEDOT composite exhibits highest sensitivity compared other this study. results indicate combination unique conducting polymer PEDOT, improves individual components. This work presents new opportunity easy‐to synthesize low‐cost MOFs/conducting provides significant insights achieve rational design desirable functional

Language: Английский

Synthesis of Novel One-Walled meso-Phenylboronic Acid-Functionalized Calix[4]pyrrole: A Highly Sensitive Electrochemical Sensor for Dopamine DOI Creative Commons
Ishfaq Ahmad Rather, Feroz Ahmad Sofi, Mohsin Ahmad Bhat

et al.

ACS Omega, Journal Year: 2022, Volume and Issue: 7(17), P. 15082 - 15089

Published: April 25, 2022

Facile access to new one-walled meso-substituted phenylboronic acid-functionalized calix[4]pyrrole (C4P) has been revealed for the first time, starting from cost-effective and easily accessible materials. The structures of both intermediate dipyrromethane (DPM) targeted functionalized C4P have confirmed by means 1H-NMR, 13C-NMR, IR, HRMS spectral data. voltammetric investigations films cast over a glassy carbon electrode (C4P-GCE) clearly establish redox stability accessibility boronic acid functional moiety present in framework. We demonstrate that presence unique functionality endows it with an excellent potential highly sensitive electrochemical sensing neurotransmitter dopamine (DA). A linear correlation between strength Faradaic signals corresponding electro-oxidation DA C4P-GCE concentration was observed range as wide 0.165-2.302 μM. exceptional reproducibility DA, nanomolar level limit detection low 15 nM.

Language: Английский

Citations

29

Stable in-vivo electrochemical sensing of tonic serotonin levels using PEDOT/CNT-coated glassy carbon flexible microelectrode arrays. DOI Creative Commons
Elisa Castagnola, Elaine M. Robbins, Daniela Krahe

et al.

Biosensors and Bioelectronics, Journal Year: 2023, Volume and Issue: 230, P. 115242 - 115242

Published: March 21, 2023

Language: Английский

Citations

20

The Role of Catecholamines in the Pathogenesis of Diseases and the Modified Electrodes for Electrochemical Detection of Catecholamines: A Review DOI
Meng Zhang, Yimeng Wang, Jie Jiang

et al.

Critical Reviews in Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 22

Published: March 10, 2024

Catecholamines (CAs), which include adrenaline, noradrenaline, and dopamine, are neurotransmitters hormones that critically regulate the cardiovascular system, metabolism, stress response in human body. The abnormal levels of these molecules can lead to development various diseases, including pheochromocytoma paragangliomas, Alzheimer's disease, Takotsubo cardiomyopathy. Due their low cost, high sensitivity, flexible detection strategies, ease integration, miniaturization, electrochemical techniques have been extensively employed CAs, surpassing traditional analytical methods. Electrochemical CAs real samples is challenging due tendency poisoning electrode. Chemically modified electrodes widely used solve problems poor sensitivity selectivity faced by bare electrodes. There a few articles provide an overview efficient enrichment but there dearth updates on role pathogenesis diseases. Additionally, still lack systematic synthesis with focus for detection. Thus, this review provides summary recent clinical published between 2017 2022. Moreover, challenges future perspectives also highlighted. This work expected useful guidance researchers entering interdisciplinary field, promoting further pathogenesis, developing more novel chemically CAs.

Language: Английский

Citations

8

Real-time in vivo detection techniques for neurotransmitters: a review DOI
Yi Su, Sumin Bian, Mohamad Sawan

et al.

The Analyst, Journal Year: 2020, Volume and Issue: 145(19), P. 6193 - 6210

Published: Jan. 1, 2020

Functional synapses in the central nervous system depend on a chemical signal exchange process that involves neurotransmitter delivery between neurons and receptor cells neuro system.

Language: Английский

Citations

46

An Investigation into the Intrinsic Peroxidase‐Like Activity of Fe‐MOFs and Fe‐MOFs/Polymer Composites DOI
Bhawana Thakur, Vikram V. Karve, Daniel T. Sun

et al.

Advanced Materials Technologies, Journal Year: 2021, Volume and Issue: 6(5)

Published: March 24, 2021

Abstract The quest for developing materials that provide a perfect trade‐off between factors such as enzyme‐like response, stability, and low cost has been long‐standing challenge in the field of biosensing. Metal‐organic frameworks (MOFs) their composites have emerged promising candidates biosensing applications due to exceptional properties tunable pore size, high specific surface area, exposed active sites. A comparative study intrinsic peroxidase‐like activity five different MOF materials: Fe‐BTC, NH 2 ‐MIL‐101(Fe), Fe‐BTC with polymers polydopamine (PDA), poly p‐phenylenediamine (PpPDA), poly(3,4‐ethylenedioxythiophene) is reported detection H O , an important biomarker biomedical diagnostics. response these toward via electrochemical colorimetric techniques mapped it found that, at neutral pH, Fe‐BTC/PEDOT composite exhibits highest sensitivity compared other this study. results indicate combination unique conducting polymer PEDOT, improves individual components. This work presents new opportunity easy‐to synthesize low‐cost MOFs/conducting provides significant insights achieve rational design desirable functional

Language: Английский

Citations

40