ACS Omega,
Journal Year:
2022,
Volume and Issue:
7(42), P. 37050 - 37060
Published: Oct. 14, 2022
An
efficient
synthesis
of
a
variety
1,2-disubstituted-5,6-dihydropyrrolo[2,1-α]isoquinoline
derivatives
via
an
acid-promoted
cyclization
reaction
between
1,2,3,4-tetrahydroisoquinoline
(THIQ)
and
substituted
α,β-unsaturated
aldehyde
is
reported.
This
cycloaddition
allows
access
to
structurally
diverse
multisubstituted
dihydropyrrolo[2,1-α]isoquinolines
in
moderate
good
yields,
which
was
the
core
scaffold
marine
natural
alkaloid
lamellarins.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(62), P. 8119 - 8122
Published: Jan. 1, 2024
A
novel
visible-light
promoted
metal-free
radical
cascade
cyclization
reaction
has
been
developed
with
3-allyl-2-arylquinazolinones
as
a
new
class
of
acceptor.
This
photocatalytic
protocol
represents
an
efficient
approach
to
construct
phosphorylated
dihydroisoquinolino[1,2-
Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 2, 2024
New
photochemical
approaches
to
2,3-fused
quinazolinones
and
dihydroquinazolinones
are
disclosed.
The
intramolecular
hydrocyclization
proceeds
in
moderate
excellent
yields
across
diverse
alkenes
with
high
regioselectivity
diastereocontrol.
Mechanistic
studies
indicated
that
the
radical
cascade
processes
involve
thiophenol
acting
as
single-electron
transfer
hydrogen
atom
reagents.
success
of
gram-scale
synthesis
proves
strategy
can
be
used
for
practical
applications.
The Journal of Organic Chemistry,
Journal Year:
2021,
Volume and Issue:
86(11), P. 7326 - 7332
Published: May 20, 2021
A
novel
solvent-free,
TfOH-promoted
decyanative
cyclization
approach
for
the
synthesis
of
2,1-benzisoxazoles
has
been
developed.
The
reactions
are
complete
instantly
at
room
temperature
and
result
in
formation
desired
a
34–97%
isolated
yield.
Asian Journal of Organic Chemistry,
Journal Year:
2021,
Volume and Issue:
10(10), P. 2421 - 2439
Published: Aug. 30, 2021
Abstract
1,2,3,4‐tetrahydroisoquinoline
(THIQ)
and
its
derivatives
possess
a
widespread
biochemical,
pharmaceutical
biological
properties
they
are
the
key
building
blocks
in
structure
of
drugs
natural
alkaloids.
Accordingly,
construction
multi‐substituted
polycyclic
THIQs
through
functionalization
at
different
positions
especially
C1‐position
have
come
to
center
attraction
recent
studies.
In
this
review,
we've
focused
on
classification
C1‐functionalization
research
articles
from
2013
on,
including
brief
description
reaction
mechanisms
for
synthesis
based
type
substituents
1‐position
THIQ
moiety.
From
point
view,
main
categories
C1‐Functionalization
with
annulation.
ACS Omega,
Journal Year:
2022,
Volume and Issue:
7(42), P. 37050 - 37060
Published: Oct. 14, 2022
An
efficient
synthesis
of
a
variety
1,2-disubstituted-5,6-dihydropyrrolo[2,1-α]isoquinoline
derivatives
via
an
acid-promoted
cyclization
reaction
between
1,2,3,4-tetrahydroisoquinoline
(THIQ)
and
substituted
α,β-unsaturated
aldehyde
is
reported.
This
cycloaddition
allows
access
to
structurally
diverse
multisubstituted
dihydropyrrolo[2,1-α]isoquinolines
in
moderate
good
yields,
which
was
the
core
scaffold
marine
natural
alkaloid
lamellarins.
