Molecules,
Journal Year:
2023,
Volume and Issue:
28(16), P. 6127 - 6127
Published: Aug. 18, 2023
The
functionalisation
of
C–H
bonds
has
been
an
enormous
achievement
in
synthetic
methodology,
enabling
new
retrosynthetic
disconnections
and
affording
simple
equivalents
for
synthons.
Hydrogen
atom
transfer
(HAT)
is
a
key
method
forming
alkyl
radicals
from
substrates.
Classic
reactions,
including
the
Barton
nitrite
ester
reaction
Hofmann–Löffler–Freytag
reaction,
among
others,
provided
early
examples
HAT.
However,
recent
developments
photoredox
catalysis
electrochemistry
have
made
HAT
powerful
tool
capable
introducing
wide
range
functional
groups
into
bonds.
Moreover,
greater
mechanistic
insights
stimulated
development
increasingly
site-selective
protocols.
Site-selectivity
can
be
achieved
through
tuning
electron
density
at
certain
using
additives,
judicious
choice
reagent,
solvent
system.
Herein,
we
describe
latest
methods
functionalizing
C–H/Si–H/Ge–H
indirect
between
2018–2023,
as
well
critical
discussion
reagents,
aspects,
substrate
scopes,
background
contexts
The Journal of Organic Chemistry,
Journal Year:
2021,
Volume and Issue:
86(13), P. 9055 - 9066
Published: June 23, 2021
A
visible-light-induced
decarboxylation
reaction
was
developed
for
the
synthesis
of
alkylated
benzimidazo[2,1-a]isoquinoline-6(5H)-ones
and
indolo[2,1-a]isoquinolin-6(5H)-ones
under
metal-free
conditions.
Impressively,
metal
catalysts
traditionally
volatile
organic
solvents
could
be
effectively
avoided.
Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
61(31)
Published: June 1, 2022
We
report
here
the
use
of
simple
and
readily
available
alkyl
sulfoxides
as
precursors
to
radicals
their
application
in
preparation
pyridine
derivatives.
show
that
sulfoxides,
N-methoxy
pyridinium
salts
fluoride
anions
form
electron
donor-acceptor
(EDA)
complexes
solution,
which,
upon
visible
light
irradiation,
undergo
a
radical
chain
process
afford
various
derivatives
smoothly.
This
reaction
displays
broad
scope
with
respect
both
pyridiniums.
The
synthetic
versatility
handle
chemistry
adds
power
precursors.
Glycosyl
are
converted
corresponding
pyridyl
C-glycosides
high
stereoselectivities.
Computational
experimental
studies
provide
insights
into
mechanism.
Green Chemistry,
Journal Year:
2022,
Volume and Issue:
24(3), P. 1302 - 1307
Published: Jan. 1, 2022
An
environmentally
friendly
multicomponent
reaction
protocol
to
synthesize
S
-alkyl
dithiocarbamate
derivatives
from
Katritzky
salt,
CS
2
,
and
secondary
amines
under
visible
light
irradiation
conditions
has
been
developed.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(16), P. 6127 - 6127
Published: Aug. 18, 2023
The
functionalisation
of
C–H
bonds
has
been
an
enormous
achievement
in
synthetic
methodology,
enabling
new
retrosynthetic
disconnections
and
affording
simple
equivalents
for
synthons.
Hydrogen
atom
transfer
(HAT)
is
a
key
method
forming
alkyl
radicals
from
substrates.
Classic
reactions,
including
the
Barton
nitrite
ester
reaction
Hofmann–Löffler–Freytag
reaction,
among
others,
provided
early
examples
HAT.
However,
recent
developments
photoredox
catalysis
electrochemistry
have
made
HAT
powerful
tool
capable
introducing
wide
range
functional
groups
into
bonds.
Moreover,
greater
mechanistic
insights
stimulated
development
increasingly
site-selective
protocols.
Site-selectivity
can
be
achieved
through
tuning
electron
density
at
certain
using
additives,
judicious
choice
reagent,
solvent
system.
Herein,
we
describe
latest
methods
functionalizing
C–H/Si–H/Ge–H
indirect
between
2018–2023,
as
well
critical
discussion
reagents,
aspects,
substrate
scopes,
background
contexts
