Light-Responsive and Dual-Targeting Liposomes: From Mechanisms to Targeting Strategies

Molecules, Journal Year: 2024, Volume and Issue: 29(3), P. 636 - 636

Published: Jan. 30, 2024

In recent years, nanocarriers have played an ever-increasing role in clinical and biomedical applications owing to their unique physicochemical properties surface functionalities. Lately, much effort has been directed towards the development of smart, stimuli-responsive that are capable releasing cargos response specific stimuli. These intelligent-responsive can be further surface-functionalized so as achieve active tumor targeting a sequential manner, which simply modulated by By applying this methodological approach, these different target-specific organs, tissues, or cells exhibit on-demand controlled drug release may enhance therapeutic effectiveness reduce systemic toxicity. Light, external stimulus, is one most promising triggers for use nanomedicine stimulate from nanocarriers. Light-triggered achieved through light irradiation at wavelengths, either UV, visible, even NIR region, depending on photophysical photo-responsive molecule embedded nanocarrier system, structural characteristics, material composition system. review, we highlighted emerging functional nanocarriers, with emphasis light-responsive liposomes dual-targeted liposomes. Moreover, provided up-to-date photo-triggered strategies mechanisms light-triggered NIR-responsive Lastly, addressed current challenges, advances, future perspectives deployment targeted delivery therapy.

Language: Английский

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Photochromic Carbon Nanomaterials: An Emerging Class of Light‐Driven Hybrid Functional Materials

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(32)

Published: June 7, 2024

Abstract Photochromic molecules have remarkable potential in memory and optical devices, as well driving manipulating molecular motors or actuators many other systems using light. When photochromic are introduced into carbon nanomaterials (CNMs), the resulting hybrids provide unique advantages create new functions that can be employed specific applications devices. This review highlights recent developments diverse CNMs. CNMs also introduced. The fundamentals of different discussed, including design principles types interactions between via covalent non‐covalent bonding such π−π stacking, amphiphilic, electrostatic, hydrogen bonding. Then properties CNMs, e.g., photopatterning, fluorescence modulation, actuation, photoinduced surface‐relief gratings, their energy storage (solar thermal fuels, photothermal batteries, supercapacitors), nanoelectronics (transistors, junctions, photo‐switchable conductance, electron transfer), sensors, bioimaging highlighted. Finally, an outlook on challenges opportunities future is presented. discusses a vibrant interdisciplinary research field expected to stimulate further nanoscience, advanced nanotechnology, intelligently responsive materials,

Language: Английский

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Smart materials for light absorptive rewritable paper: Chromic mechanisms and structural design

Materials Science and Engineering R Reports, Journal Year: 2024, Volume and Issue: 158, P. 100774 - 100774

Published: Feb. 17, 2024

Language: Английский

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General Principles for the Design of Visible‐Light‐Responsive Photoswitches: Tetra‐ortho‐Chloro‐Azobenzenes

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(48), P. 21663 - 21670

Published: Aug. 28, 2020

Molecular photoswitches enable reversible external control of biological systems, nanomachines, and smart materials. Their development is driven by the need for low energy (green-red-NIR) light switching, to allow non-invasive operation with deep tissue penetration. The lack clear design principles adaptation optimization such systems limits further applications. Here we provide a rulebook tetra-ortho-chloroazobenzenes, an emerging class visible-light-responsive photochromes, elucidating role that substituents play in defining their key characteristics: absorption spectra, band overlap, photoswitching efficiencies, half-lives unstable cis isomers. This achieved through joint photochemical theoretical analyses representative library molecules featuring varying electronic nature. A set guidelines presented enables tuning properties desired application informed photochrome engineering.

Language: Английский

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Proton-conduction photomodulation in spiropyran-functionalized MOFs with large on–off ratio

Chemical Science, Journal Year: 2019, Volume and Issue: 11(5), P. 1404 - 1410

Published: Dec. 18, 2019

A spiropyran functionalized metal–organic framework is presented, allowing to photomodulate the aqueous proton conductivity by two orders of magnitude.

Language: Английский

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