“Green Is the Color”: An Update on Ecofriendly Aspects of Organoselenium Chemistry

Molecules, Journal Year: 2022, Volume and Issue: 27(5), P. 1597 - 1597

Published: Feb. 28, 2022

Organoselenium compounds have been successfully applied in biological, medicinal and material sciences, as well a powerful tool for modern organic synthesis, attracting the attention of scientific community. This great success is mainly due to breaking paradigm demonstrated by innumerous works, that selenium were toxic would potential impact on environment. In this update review, we highlight relevance these several fields research possibility synthesize them through more environmentally sustainable methodologies, involving catalytic processes, flow chemistry, electrosynthesis, use alternative energy sources, including mechanochemical, photochemistry, sonochemical microwave irradiation.

Language: Английский

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Multiphasic Continuous‐Flow Reactors for Handling Gaseous Reagents in Organic Synthesis: Enhancing Efficiency and Safety in Chemical Processes

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 63(11)

Published: Dec. 14, 2023

The use of reactive gaseous reagents for the production active pharmaceutical ingredients (APIs) remains a scientific challenge due to safety and efficiency limitations. implementation continuous-flow reactors has resulted in rapid development gas-handling technology because several advantages such as increased interfacial area, improved mass- heat transfer, seamless scale-up. This enables shorter more atom-economic synthesis routes compounds. Herein, we provide an overview literature from 2016 onwards well gases functionalization APIs.

Language: Английский

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Green carbon science: fundamental aspects

National Science Review, Journal Year: 2023, Volume and Issue: 10(9)

Published: Feb. 24, 2023

Carbon energy has contributed to the creation of human civilization, and it can be considered that configuration carbon system is one important laws govern operation everything in universe. The core opposition unity two aspects: oxidation reduction. reduction based on ternary elemental composed three elements carbon, hydrogen oxygen. Its produces numerous reactions reaction products. Ancient Chinese philosophy helps us understand depth essence green science, explore its scientific basis, identify related platforms for technology development.

Language: Английский

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Enantioselective Flow Synthesis of a Tetrahydroquinoline SERM Enabled by Immobilized Chiral Phosphoric Acid Catalysis and Diboronic Acid Mediated Selective Nitro Reduction

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(4), P. 1024 - 1030

Published: Jan. 13, 2024

Abstract An asymmetric enantioselective flow process is reported for the formal synthesis of a 1,2,3,4‐tetrahydroquinoline selective estrogen receptor modulator. Starting from an easily available 2‐nitrochalcone, first part comprised telescoped nitro reduction/intramolecular cyclocondensation sequence using diboronic acid as simple reductant. Subsequent transfer hydrogenation in presence immobilized phosphoric organocatalyst followed by N ‐alkylation furnished targeted chiral intermediate. The approach ensures flexibility regarding scale synthesis, whilst minimizing need intermediate purifications and ensuring environmentally benign metal‐free conditions.

Language: Английский

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Towards sustainable quantum dots: Regulatory framework, toxicity and emerging strategies

Materials Science and Engineering R Reports, Journal Year: 2025, Volume and Issue: 163, P. 100940 - 100940

Published: Jan. 29, 2025

Language: Английский

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