Visible light photocatalysis in the late-stage functionalization of pharmaceutically relevant compounds

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 50(2), P. 766 - 897

Published: Dec. 22, 2020

Recent developments and future prospects of visible-light photocatalysis in the late-stage functionalization pharmaceuticals natural bioactive compounds.

Language: Английский

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Recent advances in the synthesis of biologically and pharmaceutically active quinoline and its analogues: a review

RSC Advances, Journal Year: 2020, Volume and Issue: 10(35), P. 20784 - 20793

Published: Jan. 1, 2020

Recently, quinoline has become an essential heterocyclic compound due to its versatile applications in the fields of industrial and synthetic organic chemistry. It is a vital scaffold for leads drug discovery plays major role field medicinal Nowadays there are plenty articles reporting syntheses main functionalization biological pharmaceutical activities. So far, wide range synthesis protocols have been reported literature construction this scaffold. For example, Gould-Jacob, Friedländer, Pfitzinger, Skraup, Doebner-von Miller Conrad-Limpach well-known classical used up now principal Transition metal catalysed reactions, metal-free ionic liquid mediated ultrasound irradiation reactions green reaction also useful compound. The part review focuses on highlights above-mentioned procedures findings tackle drawbacks side effects environment. Furthermore, various selected quinolines derivatives with potential activities will be presented.

Language: Английский

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Visible-light-induced decarboxylative acylation of quinoxalin-2(1H)-ones with α-oxo carboxylic acids under metal-, strong oxidant- and external photocatalyst-free conditions

Green Chemistry, Journal Year: 2020, Volume and Issue: 22(5), P. 1720 - 1725

Published: Jan. 1, 2020

An eco-friendly visible-light-induced decarboxylative acylation of quinoxalin-2(1H)-ones and α-oxo carboxylic acids with air as the oxidant under external-photocatalyst-free conditions was established.

Language: Английский

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Visible-light-induced three-component reaction of quinoxalin-2(1H)-ones, alkenes and CF3SO2Na leading to 3-trifluoroalkylated quinoxalin-2(1H)-ones

Chinese Chemical Letters, Journal Year: 2020, Volume and Issue: 32(1), P. 258 - 262

Published: Nov. 20, 2020

Language: Английский

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Visible-light-initiated 4CzIPN catalyzed multi-component tandem reactions to assemble sulfonated quinoxalin-2(1H)-ones

Chinese Chemical Letters, Journal Year: 2021, Volume and Issue: 33(3), P. 1479 - 1482

Published: Aug. 12, 2021

Language: Английский

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Recent Advances in the Catalytic Synthesis of Arylsulfonyl Compounds

ACS Catalysis, Journal Year: 2021, Volume and Issue: 11(7), P. 4169 - 4204

Published: March 19, 2021

Arylsulfonyl compounds are among the most important in pharmaceutical and medicinal chemistry. Hence, a wide variety of sulfonylation methods have been reported recently. This review summarizes arylsulfonylation methodologies developed last 5 years includes two major categories. The first entails direct second multicomponent arylsulfonylation. In arylsulfonylation, arylsulfonyl reagents react with C–H activated compounds, alkynes, alkenes through coupling or addition reactions. reactions, arylation various substrates sulfur dioxide surrogates, such as DABSO, Na2S2O5, K2S2O5. hydrazides, aryl boronic acids, silanes, halides widely employed that surrogates to generate an source, ensuing reactions proceed via pathways analogous those

Language: Английский

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Visible-light-initiated tandem synthesis of difluoromethylated oxindoles in 2-MeTHF under additive-, metal catalyst-, external photosensitizer-free and mild conditions

Chinese Chemical Letters, Journal Year: 2021, Volume and Issue: 32(6), P. 1907 - 1910

Published: Jan. 18, 2021

Language: Английский

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Photocatalyst-Free Visible-Light-Promoted C(sp²)–S Coupling: A Strategy for the Preparation of S-Aryl Dithiocarbamates

Organic Letters, Journal Year: 2019, Volume and Issue: 21(19), P. 7938 - 7942

Published: Sept. 25, 2019

We have successfully developed a green and efficient multicomponent reaction protocol to synthesize S-aryl dithiocarbamates under visible light. Most appealingly, the can proceed smoothly without adding any transition-metal catalysts, ligands, or photocatalysts while minimizing chemical wastes metal residues in end products. The advantages of this method meet requirements sustainable synthetic chemistry, it provides straightforward way create valuable dithiocarbamates.

Language: Английский

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Recent Advances in the Synthesis of C2‐Functionalized Pyridines and Quinolines Using N‐Oxide Chemistry

Advanced Synthesis & Catalysis, Journal Year: 2020, Volume and Issue: 363(1), P. 2 - 39

Published: Oct. 12, 2020

Abstract While remarkable progress has recently been made for the direct C−H‐functionalization of azines, its application is still limited by a lack accessible functional groups (primarily carbon‐based) and poor regioselectivity. In contrast, C2‐functionalized pyridines quinolines can be easily synthesized treating readily available N ‐oxides with various reagents under appropriate activation conditions. This review seeks to comprehensively document synthetic methods introducing at C2 position quinolines. this work, we highlight recent developments in C2‐functionalization pyridine quinoline address both mechanisms regioselectivity reactions. We also describe pathways reactive species involved these processes number medically relevant nitrogen heteroaromatics. magnified image

Language: Английский

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Visible-light-promoted direct C–H/S–H cross-coupling of quinoxalin-2(1H)-ones with thiols leading to 3-sulfenylated quinoxalin-2(1H)-ones in air

Organic Chemistry Frontiers, Journal Year: 2019, Volume and Issue: 6(24), P. 3950 - 3955

Published: Jan. 1, 2019

A new and efficient visible-light-mediated strategy has been developed for the synthesis of 3-sulfenylated quinoxalin-2(1H)-ones via rhodamine B catalyzed C–H/S–H cross-coupling with thiols in air at room temperature.

Language: Английский

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