Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(6), P. 873 - 873
Published: June 13, 2023
N-heterocyclic
scaffolds
represent
a
privileged
architecture
in
the
process
of
drug
design
and
development.
It
has
widespread
occurrence
synthetic
natural
products,
either
those
that
are
established
or
progressing
as
potent
candidates.
Additionally,
numerous
novel
analogues
with
remarkable
physiological
significance
extended
pharmaceutical
applications
escalating
progressively.
Hence,
classical
protocols
need
to
be
improvised
according
modern
requirements
for
efficient
eco-friendly
approaches.
Numerous
methodologies
technologies
emerged
address
green
sustainable
production
various
pharmaceutically
medicinally
important
compounds
last
few
years.
In
this
context,
current
review
unveils
greener
alternatives
direct
access
categorically
differentiated
derivatives
its
application
establishment
biologically
active
molecules
design.
The
methods
accentuated
includes
microwave-assisted
reactions,
solvent-free
approaches,
heterogeneous
catalysis,
ultrasound
biocatalysis.
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(7), P. 2596 - 2607
Published: Jan. 1, 2023
This
work
describes
a
mild
aging-hydrolysis
integrated
approach
to
selectively
produce
N
-acetyl-
d
-glucosamine
from
chitin
in
cheap
and
abundant
CaCl
2
-based
molten
salt
hydrate
solvents.
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(11), P. 4453 - 4462
Published: Jan. 1, 2023
A
novel
enzyme-mimicking
photocatalyst
was
developed
to
subtly
regulate
reactive
species
formation
at
the
atomic
level
for
control
of
selectivity
in
oxidation/ammoxidation
synthesize
biomass-derived
nitriles,
aldehydes,
or
imines
room
temperature.
Energy & Fuels,
Journal Year:
2020,
Volume and Issue:
34(9), P. 10441 - 10458
Published: Aug. 20, 2020
Biomass
is
regarded
as
an
abundant
feedstock
for
producing
renewable
biofuels
and
chemicals.
Thanks
to
their
inherent
chemical
functionality
reactivity,
biomass
resources
also
have
infinite
possibilities
replace
fossil
N-containing
compounds
by
the
introduction
of
nitrogen
heteroatoms.
Thermo-chemical
conversion
derived
substrates
with
ammonia
into
has
been
identified
a
promising
strategy
received
growing
research
interest.
This
review
summarizes
recent
progress
in
different
from
biobased
via
thermo-chemical
(TCC-A)
process,
which
provides
some
valuable
information
researchers
accomplish
sustainable
synthesis
value-added
compounds.
The
substrate
scope
covers
bioderived
small
molecules
raw
biomass.
reaction
mechanism
typical
pathway
preparation
those
compounds,
such
pyridines,
pyrroles,
indoles,
nitriles,
amines,
are
summarized
outlined.
Finally,
critical
challenges
stimulating
perspectives
provided.
Advanced Synthesis & Catalysis,
Journal Year:
2020,
Volume and Issue:
363(2), P. 411 - 424
Published: Nov. 14, 2020
Abstract
Organic
azides
are
highly
reactive,
which
have
long
established
as
versatile
building
blocks
in
the
assembly
of
structurally
diverse
N‐containing
heterocycles.
The
conversion
organic
into
high‐value
compounds
is
great
importance
and
a
subject
enormous
current
interest.
Transition
metal‐catalyzed
C(
sp
2
)−H
amination/annulation
provides
powerful
tool
for
transformation
wide
range
biologically
important
heterocyclic
frameworks.
In
this
review,
we
aim
to
summarize
recent
progress
on
azides‐mediated
N‐heterocycle
synthesis
enabled
by
transition
metal
catalysts.
Representative
strategies
discussed
detail,
including
catalytic
systems,
reaction
scopes,
limitations
mechanisms.
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