Modern Approaches in the Discovery and Development of Plant-Based Natural Products and Their Analogues as Potential Therapeutic Agents

Molecules, Journal Year: 2022, Volume and Issue: 27(2), P. 349 - 349

Published: Jan. 6, 2022

Natural products represents an important source of new lead compounds in drug discovery research. Several drugs currently used as therapeutic agents have been developed from natural sources; plant sources are specifically important. In the past few decades, pharmaceutical companies demonstrated insignificant attention towards product discovery, mainly due to its intrinsic complexity. Recently, technological advancements greatly helped address challenges and resulted revived scientific interest sources. This review provides a comprehensive overview various approaches selection, authentication, extraction/isolation, biological screening, analogue development through application modern drug-development principles plant-based products. Main focus is given bioactivity-guided fractionation approach along with associated major advancements. A brief outline historical snapshot prominent last decades also presented. The researcher’s opinions indicated that integrated interdisciplinary utilizing advances necessary for successful These involve efficient selection method, well-designed extraction/isolation procedure, advanced structure elucidation techniques, bioassays high-throughput capacity establish druggability patentability phyto-compounds. number including molecular modeling, virtual library, database mining being improving Renewed recent research trends clearly will play role future it anticipated further improve campaign.

Language: Английский

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Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery

Chemical Reviews, Journal Year: 2020, Volume and Issue: 121(6), P. 3495 - 3560

Published: Nov. 9, 2020

The crisis of antibiotic resistance necessitates creative and innovative approaches, from chemical identification analysis to the assessment bioactivity. Plant natural products (NPs) represent a promising source antibacterial lead compounds that could help fill drug discovery pipeline in response growing crisis. major strength plant NPs lies their rich unique chemodiversity, worldwide distribution ease access, various modes action, proven clinical effectiveness extracts which they are isolated. While many studies have tried summarize with activities, comprehensive review rigorous selection criteria has never been performed. In this work, literature 2012 2019 was systematically reviewed highlight plant-derived activity by focusing on growth inhibitory activity. A total 459 included Review, 50.8% phenolic derivatives, 26.6% terpenoids, 5.7% alkaloids, 17% classified as other metabolites. 183 is further discussed regarding activity, biosynthesis, structure-activity relationship, mechanism potential antibiotics. Emerging trends field plants also discussed. This Review brings forefront key findings for consideration future development efforts.

Language: Английский

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A Systematic Review of Plants With Antibacterial Activities: A Taxonomic and Phylogenetic Perspective

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 11

Published: Jan. 8, 2021

Background: Antimicrobial resistance represents a serious threat to human health across the globe. The cost of bringing new antibiotic from discovery market is high and return on investment low. Furthermore, development antibiotics has slowed dramatically since 1950s’ golden age discovery. Plants produce variety bioactive secondary metabolites that could be used fuel future pipeline. While many studies have focused specific aspects plants plant natural products with antibacterial properties, comprehensive review potential never before been attempted. Objectives: This systematic aims evaluate reports significant activities. Methods: Following PRISMA model, we searched three electronic databases: Web Science, PubMed SciFinder by using keywords: “plant,” “antibacterial,” “inhibitory concentration.” Results: We identified total 6,083 articles published between 1946 2019 then reviewed 66% these (4,024) focusing 2012 2019. A rigorous selection process was implemented clear inclusion exclusion criteria, yielding data 958 species derived 483 scientific articles. Antibacterial activity found in 51 79 vascular orders throughout phylogenetic tree. Most are reported within eudicots, bulk being asterids. not prominent monocotyledons. Phylogenetic distribution strongly supports concept chemical evolution clades, especially more eudicot families. Lamiaceae, Fabaceae Asteraceae were most represented families, while Cinnamomum verum , Rosmarinus vulgaris Thymus studied species. South Africa site collection. Crude extraction methanol type leaves main tissue investigated. Finally, Staphylococcus aureus targeted pathogenic bacteria studies. closely examine 70 medicinal 15 families literature. Conclusion: depicts current state knowledge regarding antibacterials provides powerful recommendations for research directions.

Language: Английский

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New insights of the application of water or ethanol-water plant extract rich in active compounds in food

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: March 28, 2023

Plants are recognized as natural sources of antioxidants (e.g., polyphenols, flavonoids, vitamins, and other active compounds) that can be extracted by green solvents like water, ethanol, or their binary mixtures. Plant extracts becoming more used food additives in various systems due to antioxidant abilities. Their application increases the shelf life products preventing undesirable changes nutritional sensory properties, such formation off-flavors lipid-rich food. This review summarizes most recent literature about water ethanol-water plant flavors, colorings, preservatives fortify beverages. study is performed with particular attention describing benefits extract-fortified meat, vegetable oils, biscuits, pastries, some beverages, yogurt, cheese, dairy products. Antioxidant-rich positively affect safety partially fully replacing synthetic antioxidants, which have lately been linked health issues toxicological carcinogenic consequences. On hand, limitations challenges using extract should considered, stability, level purity, compatibility matrix, price, aspects distinct taste, others. In future, continuous development a tendency use these ingredients expected, indicated number published works this area, particularly past decade.

Language: Английский

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Multifunctional nanoparticle-mediated combining therapy for human diseases

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Jan. 1, 2024

Abstract Combining existing drug therapy is essential in developing new therapeutic agents disease prevention and treatment. In preclinical investigations, combined effect of certain known drugs has been well established treating extensive human diseases. Attributed to synergistic effects by targeting various pathways advantages, such as reduced administration dose, decreased toxicity, alleviated resistance, combinatorial treatment now being pursued delivering combat major clinical illnesses, cancer, atherosclerosis, pulmonary hypertension, myocarditis, rheumatoid arthritis, inflammatory bowel disease, metabolic disorders neurodegenerative Combinatorial involves combining or co-delivering two more for a specific disease. Nanoparticle (NP)-mediated delivery systems, i.e., liposomal NPs, polymeric NPs nanocrystals, are great interest wide range due targeted delivery, extended release, higher stability avoid rapid clearance at infected areas. This review summarizes targets diseases, clinically approved combinations the development multifunctional emphasizes strategies based on severe Ultimately, we discuss challenging NP-codelivery translation provide potential approaches address limitations. offers comprehensive overview recent cutting-edge NP-mediated combination

Language: Английский

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Effects of Withania somnifera (Ashwagandha) on Stress and the Stress- Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia

Current Neuropharmacology, Journal Year: 2021, Volume and Issue: 19(9), P. 1468 - 1495

Published: July 12, 2021

Background: Withania somnifera (WS), also known as Ashwagandha, is commonly used in Ayurveda and other traditional medicine systems. WS has seen an increase worldwide usage due to its reputation adaptogen. This popularity elicited increased scientific study of biological effects, including a potential application for neuropsychiatric neurodegenerative disorders. Objective: review aims provide comprehensive summary preclinical clinical studies examining the effects WS, specifically stress, anxiety, depression, insomnia. Methods: Reports human trials animal were collected primarily from PubMed, Scopus, Google Scholar databases. Results: root leaf extracts exhibited noteworthy anti-stress anti-anxiety activity studies. improved symptoms depression insomnia, though fewer investigated these applications. may alleviate conditions predominantly through modulation hypothalamic-pituitary-adrenal sympathetic-adrenal-medullary axes, well GABAergic serotonergic pathways. While some link specific withanolide components benefits, there evidence presence additional, yet unidentified, active compounds WS. Conclusion: benefits reviewed studies, significant variability examined prevents consensus on optimum preparation or dosage treating conditions. generally appears safe use; however, it will be important investigate herb-drug interactions involving if alongside pharmaceutical interventions. Further elucidation needed.

Language: Английский

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Essential Oils as Multicomponent Mixtures and Their Potential for Human Health and Well-Being

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 24, 2022

Essential oils (EOs) and their individual volatile organic constituents have been an inherent part of our civilization for thousands years. They are widely used as fragrances in perfumes cosmetics contribute to a healthy diet, but also act active ingredients pharmaceutical products. Their antibacterial, antiviral, anti-inflammatory properties qualified EOs early on both, the causal symptomatic therapy number diseases, prevention. Obtained from natural, mostly plant materials, constitute typical example multicomponent mixture (more than one constituent substances, MOCS) with up several hundreds compounds, which sophisticated composition make property particular complete EO. The integrative use MOCS will play major role human veterinary medicine now future is already some cases, e.g. , aromatherapy treatment psychosomatic complaints, inhalation respiratory or topically administered manage adverse skin diseases. diversity molecules different functionalities exhibits broad range multiple physical chemical properties, base multi-target activity opposed single isolated compounds. Whether how such broad-spectrum effect reflected natural mixtures kind pharmacological potential they provide be considered context ONE Health more detail this review.

Language: Английский

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Mechanisms and regulation of defensins in host defense

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Aug. 14, 2023

As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth cells, neutrophils, and epithelial contributing to defense. Their biological functions in innate immunity, as well their structure activity relationships, along with mechanisms action therapeutic potential, have been great interest recent years. To highlight the key research into role human animal health, we first describe history, structural features, evolution, antimicrobial mechanisms. Next, cover immune homeostasis, chemotaxis, mucosal barrier function, gut microbiota regulation, intestinal development regulation cell death. Further, discuss clinical relevance potential various diseases, including infectious disease, inflammatory bowel diabetes obesity, chronic lung periodontitis cancer. Finally, summarize current knowledge regarding nutrient-dependent defensins, fatty acids, amino microelements, plant extracts, probiotics, while considering application such regulation. Together, review summarizes functions, mechanism actions significance challenges developing defensins-based therapy, thus providing crucial insights biology utility.

Language: Английский

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3D printed MCT oleogel as a co-delivery carrier for curcumin and resveratrol

Biomaterials, Journal Year: 2022, Volume and Issue: 287, P. 121616 - 121616

Published: June 2, 2022

Language: Английский

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High-Throughput Screening of Natural Product and Synthetic Molecule Libraries for Antibacterial Drug Discovery

Metabolites, Journal Year: 2023, Volume and Issue: 13(5), P. 625 - 625

Published: May 2, 2023

Due to the continued emergence of resistance and a lack new promising antibiotics, bacterial infection has become major public threat. High-throughput screening (HTS) allows rapid large collection molecules for bioactivity testing holds promise in antibacterial drug discovery. More than 50% antibiotics that are currently available on market derived from natural products. However, with easily discoverable being found, finding sources seen limited success. Finding activity also proven be challenging. In addition exploring products synthetic biology, omics technology helped study biosynthetic machinery existing enabling construction unnatural synthesizers bioactive identification molecular targets agents. On other hand, newer smarter strategies have been continuously pursued screen molecule libraries druggable targets. Biomimetic conditions explored mimic real model better ligand–target interaction enable designing more effective drugs. This narrative review describes various traditional contemporaneous approaches high-throughput It further discusses critical factors HTS assay design, makes general recommendation, possible alternatives

Language: Английский

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