Catalysts,
Journal Year:
2022,
Volume and Issue:
12(5), P. 510 - 510
Published: May 2, 2022
C−H
methylation
of
sp2
and
sp3
carbon
centers
is
significant
in
many
biological
processes.
Methylated
drug
candidates
show
unique
properties
due
to
the
change
solubility,
conformation
metabolic
activities.
Several
photo-catalyzed,
electrochemical,
mechanochemical
metal-free
techniques
that
are
widely
utilized
strategies
medicinal
chemistry
for
arenes
heteroarenes
have
been
covered
this
review.
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(9), P. 5517 - 5563
Published: Jan. 1, 2021
Following
notable
cases
of
remarkable
potency
increases
in
methylated
analogues
lead
compounds,
this
review
documents
the
state-of-the-art
C–H
methylation
technology.
Chemical Communications,
Journal Year:
2023,
Volume and Issue:
59(36), P. 5343 - 5364
Published: Jan. 1, 2023
The
activation
and
transformation
of
organic
chemical
bonds
is
a
fundamental
scientific
problem.
In
the
past
several
decades,
C-S
bond
cleavage
for
construction
C-C
C-heteroatom
has
received
tremendous
attention
in
chemistry.
Although
significant
progress
been
made
field
transition
metal
strategies,
variety
novel
transition-metal-free
strategies
have
also
developed
using
halogenated
reagents,
oxidants,
acids,
bases.
Moreover,
photochemical
electrochemical
methods
to
achieve
organosulfur
compounds.
To
date,
however,
no
comprehensive
review
reported.
Therefore,
we
herein
provide
major
advances
compounds,
including
thioethers,
sulfoxides,
sulfones,
thioacetals,
sulfonium
salts,
sulfur
ylides.
Advanced Synthesis & Catalysis,
Journal Year:
2019,
Volume and Issue:
362(1), P. 65 - 86
Published: Sept. 20, 2019
Abstract
Dimethyl
sulfoxide
(DMSO)
has
had
a
long
history
of
use
as
polar
solvent
and
active
pharmaceutical
ingredient
in
the
past
decades.
However,
this
decade
DMSO
attracted
attention
scientists
source
oxygen,
carbon
or
sulfur
wide
range
organic
reactions.
In
review,
we
have
summarized
classified
latest
findings
area
based
on
applications
single
dual
synthon.
magnified
image
Chemistry - A European Journal,
Journal Year:
2021,
Volume and Issue:
27(46), P. 11751 - 11772
Published: June 2, 2021
Abstract
In
the
field
of
medicinal
chemistry,
precise
installation
a
trideuteromethyl
group
is
gaining
ever‐increasing
attention.
Site‐selective
incorporation
deuterated
“magic
methyl”
can
provide
profound
pharmacological
benefits
and
be
considered
an
important
tool
for
drug
optimization
development.
This
review
provides
structured
overview,
according
to
trideuteromethylation
reagent,
currently
established
methods
site‐selective
carbon
atoms.
addition
CD
3
,
selective
introduction
2
H
CDH
groups
also
considered.
For
all
methods,
corresponding
mechanism
scope
are
discussed
whenever
reported.
As
such,
this
starting
point
synthetic
chemists
further
advance
methodologies.
At
same
time,
aims
guide
chemists,
offering
them
available
C−CD
formation
strategies
preparation
new
or
modified
drugs.
Organic Letters,
Journal Year:
2021,
Volume and Issue:
23(10), P. 3960 - 3964
Published: May 3, 2021
A
selective
and
efficient
synthesis
of
diaryl
1,3,5-oxadiazines
was
established
for
the
first
time
from
simple
readily
available
amidines
in
wet
DMSO.
DMSO
employed
as
a
dual
carbon
synthon
water
offered
oxygen
atom
to
construct
oxadiazine
ring.
The
reaction
involved
two
new
C–N
C–O
bond
formations.
Chemical Communications,
Journal Year:
2022,
Volume and Issue:
58(21), P. 3497 - 3500
Published: Jan. 1, 2022
A
regioselective
deuteration
at
the
β-
and
γ-position
of
pyridines
is
reported.
Efficient
occurred
with
a
combination
KOtBu
DMSO-d6,
replenishing
prevailing
α-deuteration
pyridine
systems.
Preliminary
mechanistic
studies
suggested
that
dimsyl
carbanion
acts
as
one
key
intermediates.
Organic & Biomolecular Chemistry,
Journal Year:
2019,
Volume and Issue:
18(2), P. 205 - 210
Published: Nov. 28, 2019
An
effective
approach
to
realize
the
direct
methylation
of
imidazo[1,2-a]pyridines
and
quinoxalin-2(1H)-ones
with
peroxides
under
metal-free
conditions
is
described.
In
this
protocol,
serve
as
both
radical
initiator
methyl
source.
Methylated
imidazopyridines
were
smoothly
synthesized
in
moderate
good
yields.
A
free
reaction
mechanism
was
proposed
describe
process.
Green Chemistry,
Journal Year:
2020,
Volume and Issue:
22(11), P. 3506 - 3511
Published: Jan. 1, 2020
Herein
described
a
novel
and
an
efficient
route
for
the
site
selective
functionalization
of
aza-heteroarenes
using
combination
PEG-400,
O2and
TsOH·H2O.
ACS Catalysis,
Journal Year:
2021,
Volume and Issue:
11(17), P. 10713 - 10732
Published: Aug. 13, 2021
Methylation
is
an
important
process
in
biology.
To
date,
radical-type
methylation
protocols
have
been
developed
the
late-stage
modifications
of
privileged
scaffolds
pharmaceutical
research
and
medicinal
materials
sciences.
As
a
result,
chemistry
methyl-radical-involved
conversions,
which
was
significant
topic
interest
over
past
few
years,
has
greatly
developed.
This
review
focuses
on
most
recent
developments
catalytic
radical
or
demethylation
that
were
mediated
by
methyl
radicals.
We
classify
reactions
according
to
origination
species
illustrate
diversity
radical-based
mechanisms;
these
generation
pathways
include
(1)
photo-/electro-catalysis,
(2)
transition-metal
catalysis,
(3)
transition-metal-free
methylations,
(4)
demethylation-triggered
cyclization/cascade
reactions.
In
addition
mechanisms,
some
representative
methyl-containing
molecules
produced
from
specific
are
presented
analyzed.
