Organic & Biomolecular Chemistry, Journal Year: 2023, Volume and Issue: 21(47), P. 9428 - 9432
Published: Jan. 1, 2023
An efficient strategy for divergent aromatic ring nitrosation and nitration of amides was developed using NOBF 4 as the electrophile under silver-catalyzed conditions.
Language: Английский
Organic Process Research & Development, Journal Year: 2020, Volume and Issue: 24(9), P. 1558 - 1585
Published: July 28, 2020
Recent drug recalls (e.g., valsartan and ranitidine) linked to the discovery of nitrosamine impurities have led increased regulatory scrutiny in manufacturing process marketed medicines, notably for determining any sources risk (or related N-nitroso compound) formation within process. This review seeks aid assessment through identifying known conditions reactants which compounds can be formed.
Language: Английский
Citations
90
Organic Chemistry Frontiers, Journal Year: 2020, Volume and Issue: 7(18), P. 2873 - 2898
Published: Jan. 1, 2020
Significant progress in the chemistry of nitro radicals has been witnessed past decades, providing efficient and rapid access to nitro-containing compounds. This review describes recent advances nitro-involved radical reactions, summarizes various transformations.
Language: Английский
Citations
47
Journal of Saudi Chemical Society, Journal Year: 2021, Volume and Issue: 25(2), P. 101194 - 101194
Published: Jan. 9, 2021
A class of novel benzimidazole-containing flavonoid derivatives were constructed. Antibacterial bioassay showed that most the target compounds displayed good inhibitory effects against Xanthomonas axonopodis pv. citri (Xac), Ralstonia solanacearum (Rs) and oryzae (Xoo). Remarkably, compound 4e outstanding antibacterial activity Rs, with EC50 14.5 µg/mL, which was better than thiodiazole-copper (118.9 µ/mL), bismerthiazol (55.1 µg/mL) myricetin (82.3 µg/mL). At same time, mechanism confirmed by scanning electron microscopy (SEM). Antiviral results demonstrated 4n remarkable curative, protective inactivating activities tobacco mosaic virus (TMV), a 500 µg/mL effective concentration 54.1, 57.6 75.3%, respectively. The test revealed these values or close to ningnanmycin (49.0, 55.8 82.7%, respectively). Microscale thermophoresis (MST) also binding TMV coat protein (TMV-CP) gave Kd value 1.049 ± 0.582 µmol/L, (1.058 0.286 µmol/L). This study are promising agricultural antiviral agents.
Language: Английский
Citations
37
Journal of Molecular Liquids, Journal Year: 2022, Volume and Issue: 348, P. 118447 - 118447
Published: Jan. 4, 2022
Language: Английский
Citations
24
Advanced Synthesis & Catalysis, Journal Year: 2020, Volume and Issue: 362(22), P. 5036 - 5043
Published: June 23, 2020
Abstract An acid‐free N‐nitrosation/nitration of the N−H bonds in secondary amines with Fe(NO 3 ) ⋅ 9H 2 O as nitroso/nitro source through an electrocatalyzed radical coupling reaction was developed. Cyclic aliphatic and N‐heteroaromatic compounds were N‐nitrosated N‐nitrated, respectively, under mild conditions. Control competition experiments, well kinetic studies, demonstrate that N‐nitrosation N‐nitration involve two different pathways involving N + . radicals. Moreover, electrocatalysis method enables preferential activation bond over electrode thus provides high selectivity for specific atoms. Finally, this strategy exhibits a broad scope green straightforward approach to generate useful ‐nitroso/nitro good yields. magnified image
Language: Английский
Citations
28
ACS Sustainable Chemistry & Engineering, Journal Year: 2020, Volume and Issue: unknown
Published: July 16, 2020
An effective and simple visible light-induced heterogeneous g-C3N4-catalyzed decarboxylative reaction of quinoxalin-2(1H)-ones with N-aryl glycines was developed. When the performed in DMSO/H2O EtOH, products dihydroquinoxalin-2(1H)-ones tetrahydroimidazo[1,5-a]quinoxalin-4(5H)-ones were unprecedentedly obtained good yields, respectively. This solvent-dependent system offers advantages, including easy operation, short time, high chemoselectivity, a recyclable catalyst, metal-/base-/oxidant-free, mild conditions.
Language: Английский
Citations
18
Organic Chemistry Frontiers, Journal Year: 2020, Volume and Issue: 7(17), P. 2467 - 2473
Published: Jan. 1, 2020
A
strategy
has
been
developed
to
synthesize
α-carbonylfuran
and
isoxazole
using
Language: Английский
Citations
17
Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 112(5), P. 1333 - 1340
Published: March 4, 2023
Language: Английский
Citations
5
Organic Chemistry Frontiers, Journal Year: 2021, Volume and Issue: 8(20), P. 5821 - 5830
Published: Jan. 1, 2021
Within the scope of nitration reactions, efficiency sensitive heteroaromatics such as indoles is often eroded by various competitive oxidative decomposition pathways.
Language: Английский
Citations
11
Chemistry - An Asian Journal, Journal Year: 2022, Volume and Issue: 17(16)
Published: May 25, 2022
An on-water approach has been developed that allows a nitration of tyrosines and phenols under mild conditions. We envisioned the assembly tyrosine/tyrosyl radical couples with interfacial water molecules would realize biomimetic stacking hydrogen atom transfer (HAT) transition state to facilitate electron-transfer process. The optimal organic nitrite, 2-methoxyethyl resulted in rapid coupling tyrosyl radicals ⋅NO2 at oil-water interface afford nitrated phenols. Many characteristics found our strategy are distinct from other complementary systems include nitration. These enticing roles reaction process introduce new avenues explore design synthetic chemistry systems.
Language: Английский
Citations
8