Published: Jan. 1, 2024
Language: Английский
Exploration, Journal Year: 2023, Volume and Issue: 3(1)
Published: Feb. 1, 2023
The methodological advancements in surface-enhanced Raman scattering (SERS) technique with nanoscale materials based on noble metals, Au, Ag, and their bimetallic alloy Au-Ag, has enabled the highly efficient sensing of chemical biological molecules at very low concentration values. By employing innovative various type Ag nanoparticles especially, high efficiency Au@Ag nanomaterials as substrate SERS biosensors have revolutionized detection components including; proteins, antigens antibodies complex, circulating tumor cells, DNA, RNA (miRNA), etc. This review is about SERS-based Au/Ag enhanced activity by focusing different factors related to them. emphasis this research describe recent developments field conceptual behind Furthermore, article we apex understanding impact variation basic features like effects size, shape varying lengths, thickness core-shell influence large-scale magnitude morphology. Moreover, detailed information applications these importantly receptor binding domain (RBD) protein COVID-19 provided.
Language: Английский
Citations
86
Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(13), P. 8297 - 8346
Published: June 15, 2023
Omics technologies have rapidly evolved with the unprecedented potential to shape precision medicine. Novel omics approaches are imperative toallow rapid and accurate data collection integration clinical information enable a new era of healthcare. In this comprehensive review, we highlight utility Raman spectroscopy (RS) as an emerging technology for clinically relevant applications using significant samples models. We discuss use RS both label-free approach probing intrinsic metabolites biological materials, labeled where signal from reporters conjugated nanoparticles (NPs) serve indirect measure tracking protein biomarkers
Language: Английский
Citations
77
ACS Nano, Journal Year: 2024, Volume and Issue: 18(15), P. 10596 - 10608
Published: April 1, 2024
Continuously monitoring neurotransmitter dynamics can offer profound insights into neural mechanisms and the etiology of neurological diseases. Here, we present a miniaturized implantable fluorescence probe integrated with metal-organic frameworks (MOFs) for deep brain dopamine sensing. The is assembled from physically thinned light-emitting diodes (LEDs) phototransistors, along functional surface coatings, resulting in total thickness 120 μm. A fluorescent MOF that specifically binds introduced, enabling highly sensitive measurement detection limit 79.9 nM. compact wireless circuit weighing only 0.85 g also developed interfaced probe, which was later applied to continuously monitor real-time levels during stimulation rats, providing critical information on dynamics. Cytotoxicity tests immunofluorescence analysis further suggest favorable biocompatibility applications. This work presents fundamental principles techniques integrating MOFs flexible electronics brain-computer interfaces may provide more customized platforms applications neuroscience, disease tracing, smart diagnostics.
Language: Английский
Citations
17
Nanoscale Advances, Journal Year: 2023, Volume and Issue: 5(8), P. 2132 - 2166
Published: Jan. 1, 2023
NIR-SERS and the concomitant tailoring of detection setup, as well tuning shape, material, architecture enhancing substrates, allow for bioanalytical studies, including cell through-tissue measurements.
Language: Английский
Citations
24
Annual Review of Analytical Chemistry, Journal Year: 2024, Volume and Issue: 17(1), P. 313 - 338
Published: May 3, 2024
A frontier of analytical sciences is centered on the continuous measurement molecules in or near cells, tissues, organs, within biological context situ, where molecular-level information indicative health status, therapeutic efficacy, and fundamental biochemical function host. Following completion Human Genome Project, current research aims to link genes functions an organism investigate how environment modulates functional properties organisms. New methods have been developed detect chemical changes with high spatial temporal resolution, including minimally invasive surface-enhanced Raman scattering (SERS) nanofibers using principles endoscopy (SERS nanoendoscopy) optical physiology optophysiology). Given large spectral data sets generated from these experiments, SERS nanoendoscopy optophysiology benefit advances science machine learning extract complex vibrational spectra measured by SERS. This review highlights new opportunities for intracellular, extracellular, vivo measurements arising combination nanosensing learning.
Language: Английский
Citations
10
ACS Nano, Journal Year: 2024, Volume and Issue: 18(34), P. 22620 - 22647
Published: Aug. 1, 2024
Monitoring neurochemicals and imaging the molecular content of brain tissues
Language: Английский
Citations
9
Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101271 - 101271
Published: March 1, 2025
Language: Английский
Citations
1
Microchemical Journal, Journal Year: 2021, Volume and Issue: 169, P. 106526 - 106526
Published: June 19, 2021
Language: Английский
Citations
31
Molecules, Journal Year: 2024, Volume and Issue: 29(5), P. 979 - 979
Published: Feb. 23, 2024
Understanding and classifying inherent tumor heterogeneity is a multimodal approach, which can be undertaken at the genetic, biochemical, or morphological level, among others. Optical spectral methods such as Raman spectroscopy aim rapid non-destructive tissue analysis, where each spectrum generated reflects individual molecular composition of an examined spot within (heterogenous) sample. Using combination supervised unsupervised machine learning well solid database spectra native glioblastoma samples, we succeed not only in distinguishing explicit areas—vital necrotic correctly predicted with accuracy 76%—but also determining different entities histomorphologically distinct class vital tissue. Measurements non-pathological, autoptic brain hereby serve healthy control since their respective spectroscopic properties form reproducible cluster The demonstrated decipherment will valuable, especially field spectroscopically guided surgery to delineate margins assist resection control.
Language: Английский
Citations
4
Chemistry - An Asian Journal, Journal Year: 2022, Volume and Issue: 17(7)
Published: Feb. 18, 2022
Abstract Surface‐enhanced Raman scattering (SERS) has received considerable attention from researchers due to its high molecular specificity, sensitivity, non‐invasiveness and multiplexing. Recently, various metal substrates have been exploited for SERS analysis imaging. Among them, gold nanomaterials are important with outstanding surface plasmon resonance effects, structural adjustability good biocompatibility, making them widely used in biomedical diagnosis clinical fields. In this minireview, we discuss the latest progress about application of gold‐based as probes research, primarily vivo disease This review mainly includes basic shapes morphologies based probes, such nanoparticles (AuNPs), nanorods (AuNRs), nanostars (AuNSs), well other nanostructures. Finally, a brief outlook future development technique context efficient diagnostics therapy guidance is provided. We hope that will facilitate design surface‐enhanced on nanomaterials.
Language: Английский
Citations
19