ChemistrySelect, Journal Year: 2021, Volume and Issue: 6(13), P. 3267 - 3270
Published: April 7, 2021
Abstract A tandem conjugate addition/aromatization/acyl transfer reaction between 3‐aryl‐2‐nitropropanoates and quinone monoimines was described. In the presence of NMM, proceeded smoothly to give various 1,2‐diarylnitroethanes in low good yields. The structure one product determined by an X‐ray crystal structural analysis. Accordingly, a plausible mechanism proposed.
Language: Английский
Molecules, Journal Year: 2024, Volume and Issue: 29(11), P. 2481 - 2481
Published: May 24, 2024
Quinone imines are important derivatives of quinones with a wide range applications in organic synthesis and the pharmaceutical industry. The attack nucleophilic reagents on quinone tends to lead aromatization skeleton, resulting both high reactivity unique imines. extreme value construction nitrogen- or oxygen-containing heterocycles has attracted widespread attention, remarkable advances have been reported recently. This review provides an overview application cyclic compounds via domino annulation reaction.
Language: Английский
Citations
0
The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(24), P. 18640 - 18648
Published: Nov. 26, 2024
We have developed a hemin-catalyzed biomimetic oxidative annulation of 2,3-dihydroxybenzoic acid with an array cyclic enamines to form isochromanones in good excellent yields and high regioselectivity. This formal [4+2] cycloaddition protocol showed efficiency remarkable functional group tolerance. Mechanistic studies indicate the involvement single-electron oxidation pathway. Preliminary biological investigations that 3ag 3ca exhibited antineoplastic activities against MCF-7 cell lines IC50 values 25.21 29.09 μM, respectively.
Language: Английский
Citations
0
ChemistrySelect, Journal Year: 2021, Volume and Issue: 6(13), P. 3267 - 3270
Published: April 7, 2021
Abstract A tandem conjugate addition/aromatization/acyl transfer reaction between 3‐aryl‐2‐nitropropanoates and quinone monoimines was described. In the presence of NMM, proceeded smoothly to give various 1,2‐diarylnitroethanes in low good yields. The structure one product determined by an X‐ray crystal structural analysis. Accordingly, a plausible mechanism proposed.
Language: Английский
Citations
0