Lemon Juice: A Versatile Biocatalyst and Green Solvent in Organic Transformations DOI
Baji Baba Shaik, Pule Seboletswe, Sachin Balaso Mohite

et al.

ChemistrySelect, Journal Year: 2022, Volume and Issue: 7(5)

Published: Feb. 1, 2022

Abstract Green chemistry is the basis for fast‐growing, eco‐friendly, alternative sustainable technologies development of chemical products without use or generation hazardous catalysts. The role naturally occurring fruit juice as a catalyst solvent in organic synthesis has gained focused interest across globe. Lemon juice‐mediated been widely explored recently highly significant, selective and biocatalyst synthesis. This review presents recent developments on lemon‐juice mediated transformations their application to synthesize molecules building blocks pharmaceutical interest. We believe this article will be researchers both academic industrial settings developing novel pharmacophores from green principles perspective.

Language: Английский

Cu-Catalyzed Divergent Transformations of Allenylethylene Carbonates with Diboron Reagents DOI

Si-Jie Chen,

Xiaojie Su, Yujie Dong

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(4), P. 960 - 965

Published: Jan. 19, 2024

Divergent transformations of allenylethylene carbonates with diboron reagents catalyzed by copper are disclosed. By using CuCl/IPr·HCl as the catalyst, react B2hex2 to afford 2,4-dien-1-ols product in presence Cs2CO3 base, iPrOH additive, and 1,4-dioxane solvent. And they B2pin2 form boronic half acids NaOtBu water THF The reactions corresponding products good stereoselectivities yields, further derivatizations study mechanism also demonstrated.

Language: Английский

Citations

3
Merging Organocatalysis with 1,2-Boronate Rearrangement: A Lewis Base-Catalyzed Asymmetric Multicomponent Reaction DOI Creative Commons

Hong‐Cheng Shen,

Varinder K. Aggarwal

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(40), P. 27305 - 27311

Published: Sept. 24, 2024

Catalytic asymmetric multicomponent 1,2-boronate rearrangements provide a practical approach for synthesizing highly valuable enantioenriched boronic esters. When applied to alkenyl or heteroaryl boronates, these reactions have relied mainly on transition-metal catalysis. Herein, we present an organocatalytic, Lewis base-catalyzed rearrangement, involving indoles, esters, and Morita-Baylis-Hillman carbonates, leading enantioenriched, substituted indole indoline derivatives. Using cinchona alkaloid-based catalysts, high selectivity has been achieved, enabling expansion of the chemical space around pharmaceutically relevant

Language: Английский

Citations

3
Enantioselective Borylative Functionalization of Internal Alkenes: A Platform for Constructing Vicinal Stereocenters† DOI
Yu‐Jie Zhu, Jiaxin Li, Haotian Zhao

et al.

Chinese Journal of Chemistry, Journal Year: 2024, Volume and Issue: 42(24), P. 3588 - 3604

Published: Nov. 1, 2024

Comprehensive Summary Vicinal stereogenic centers are ubiquitous structural scaffolds in both natural products and synthetic compounds, yet their enantioselective construction remains a significant challenge organic synthesis. Organoboron compounds of paramount importance chemistry due to ability undergo facile transformations, yielding diverse essential chemical bonds such as carbon‐carbon, carbon‐oxygen, carbon‐nitrogen, carbon‐halogen bonds. Transition‐metal‐catalyzed asymmetric borylative functionalizations internal alkenes offer promising strategy for the installation two adjacent chiral across carbon‐carbon By leveraging versatile transformations newly introduced boryl unit, this approach holds great potential expanding diversity vicinal scaffolds. In concise review, we aim highlight recent advancements transition‐metal‐catalyzed alkenes, underscore utility constructing centers, discuss unsolved challenges future directions field. Key Scientists

Language: Английский

Citations

3
Recent advances in the synthesis and reactivity of MIDA boronates DOI

Debasis Aich,

Parveen Kumar,

Debraj Ghorai

et al.

Chemical Communications, Journal Year: 2022, Volume and Issue: 58(96), P. 13298 - 13316

Published: Jan. 1, 2022

MIDA boronates have been widely applied as building blocks in the synthesis of natural products and pharmaceuticals precursors. This review highlights recent advances provides a comprehensive summary their reactivity.

Language: Английский

Citations

16
Lemon Juice: A Versatile Biocatalyst and Green Solvent in Organic Transformations DOI
Baji Baba Shaik, Pule Seboletswe, Sachin Balaso Mohite

et al.

ChemistrySelect, Journal Year: 2022, Volume and Issue: 7(5)

Published: Feb. 1, 2022

Abstract Green chemistry is the basis for fast‐growing, eco‐friendly, alternative sustainable technologies development of chemical products without use or generation hazardous catalysts. The role naturally occurring fruit juice as a catalyst solvent in organic synthesis has gained focused interest across globe. Lemon juice‐mediated been widely explored recently highly significant, selective and biocatalyst synthesis. This review presents recent developments on lemon‐juice mediated transformations their application to synthesize molecules building blocks pharmaceutical interest. We believe this article will be researchers both academic industrial settings developing novel pharmacophores from green principles perspective.

Language: Английский

Citations

15