New Journal of Chemistry,
Journal Year:
2022,
Volume and Issue:
46(24), P. 11877 - 11882
Published: Jan. 1, 2022
Unique
polyheterocyclic
compounds
were
efficiently
synthesized
by
cascade
reaction
of
the
in
situ
generation
a
special
kind
azomethine
ylide,
1,3-dipolar
cycloaddition
and
annulation
phenoxide.
European Journal of Organic Chemistry,
Journal Year:
2021,
Volume and Issue:
2021(24), P. 3472 - 3477
Published: June 7, 2021
Abstract
A
protocol
for
the
stereoselective
synthesis
of
alkylidenephthalides
and
indanediones
has
been
developed
through
reaction
o
‐hydroxychalcones
their
styrenyl
analogues,
respectively,
with
3‐sulfonylphthalide.
The
mechanism
former
involves
Michael
addition‐E
2
elimination
sequence,
while
latter
a
[4+1]
Hauser‐Kraus
annulation.
mechanistic
studies
reveal
that
strategically
positioned
phenolic
group
plays
pivotal
role
in
observed
reactivities.
alkylidenephthalides,
which
are
latent
1,4‐dicarbonyl
compounds,
were
further
converted
to
triarylfurans
under
Paal‐Knorr
conditions
good
excellent
yields.
This
unravels
several
key
features
such
as
substrate
specific
product
formation,
namely,
from
chalcones,
vinylogous
chalcones
3‐sulfonylphthalide
well
surrogates
furan
synthesis.
ChemistrySelect,
Journal Year:
2021,
Volume and Issue:
6(47), P. 13589 - 13594
Published: Dec. 16, 2021
Abstract
A
simple
and
convenient
protocol
has
been
demonstrated
for
the
construction
of
spiro[chroman‐3,2′‐indanedione]
via
Oxa‐Michael/Michael
cascade
reaction
sequence
using
2‐arylidene‐1,3‐indanedione
(
E
)‐2‐(2‐nitrovinyl)phenol.
This
[4+2]
cyclisation
results
in
generation
two
stereocentres
along
with
an
all
carbon
quaternary
centre
good
to
high
chemical
yields
upto
93
%.
triple
approach
was
carried
out
[1+1+4]
protocol.
