Marine Life Science & Technology,
Journal Year:
2023,
Volume and Issue:
5(1), P. 85 - 93
Published: Jan. 20, 2023
Further
insights
on
the
secondary
metabolites
of
a
soft
coral-derived
fungus
Aspergillus
versicolor
under
guidance
MS/MS-based
molecular
networking
led
to
isolation
seven
known
cycloheptapeptides,
namely,
asperversiamides
A-C
(1-3)
and
asperheptatides
A-D
(4-7)
an
unusual
pyrroloindoline-containing
new
cycloheptapeptide,
asperpyrroindotide
A
(8).
The
structure
8
was
elucidated
by
comprehensive
spectroscopic
data
analysis,
its
absolute
configuration
determined
advanced
Marfey's
method.
semisynthetic
transformation
1
into
successfully
achieved
reaction
conditions
were
optimized.
Additionally,
series
derivatives
(10-19)
asperversiamide
(1)
semi-synthesized
their
anti-tubercular
activities
evaluated
against
Mycobacterium
tuberculosis
H37Ra.
preliminary
structure-activity
relationships
revealed
that
serine
hydroxy
groups
tryptophan
residue
are
important
activity.The
online
version
contains
supplementary
material
available
at
10.1007/s42995-022-00157-8.
Marine Drugs,
Journal Year:
2021,
Volume and Issue:
20(1), P. 29 - 29
Published: Dec. 25, 2021
In
the
past
decade,
several
antibodies
directed
against
PD-1/PD-L1
interaction
have
been
approved.
However,
therapeutic
also
exhibit
some
shortcomings.
Using
small
molecules
to
regulate
pathway
may
be
another
way
mobilize
immune
system
fight
cancer.52,765
marine
natural
products
were
screened
PD-L1(PDBID:
6R3K).
To
identify
compounds,
a
structure-based
pharmacophore
model
was
generated,
following
by
virtual
screening
and
molecular
docking.
Then,
absorption,
distribution,
metabolism,
excretion
(ADME)
test
carried
out
select
most
suitable
compounds.
Finally,
dynamics
simulation
performed
validate
binding
property
of
top
compound.Initially,
12
based
on
model.
two
compounds
selected
for
further
evaluation
docking
scores.
After
ADME
toxicity
studies,
molecule
51320
verification.
By
analysis,
maintains
stable
conformation
with
target
protein,
so
it
has
chance
become
an
inhibitor
PD-L1.Through
modeling,
screening,
docking,
ADMET
approaches,
(MD)
simulation,
compound
can
used
as
PD-L1.
PeerJ,
Journal Year:
2022,
Volume and Issue:
10, P. e13405 - e13405
Published: May 31, 2022
Food
safety
is
a
significant
challenge
worldwide,
from
plantation
to
cultivation,
especially
for
perishable
products
such
as
tomatoes.
New
eco-friendly
strategies
are
needed,
and
beneficial
microorganisms
might
be
sustainable
solution.
This
study
demonstrates
bacteria
activity
in
the
tomato
plant
rhizosphere.
Further,
it
investigates
rhizobacteria’s
structure,
function,
diversity
soil.
Rhizobacteria
that
promote
growth
development
of
plants
referred
growth-promoting
(PGPR).
They
form
series
associations
with
other
organisms
soil
through
mutualistic
relationship
where
both
parties
benefit
living
together.
It
implies
antagonistic
activities
rhizobacteria
deter
pathogens
invading
their
roots.
Some
PGPR
regarded
biological
control
agents
hinder
spoilage
can
act
an
alternative
agricultural
chemicals
may
detrimental
health
humans,
animals,
some
microbes
rhizosphere
These
also
help
acquire
essential
nutrients
like
potassium
(K),
magnesium
(Mg),
phosphorus
(P),
nitrogen
(N).
offer
solution
low
production
tackle
food
insecurity
farming
problems.
In
this
review,
overview
soil-inhabiting
focused
on
improving
Solanum
lycopersicum
.
Marine Life Science & Technology,
Journal Year:
2022,
Volume and Issue:
4(3), P. 356 - 372
Published: Aug. 1, 2022
Marine
sponges
are
productive
sources
of
bioactive
secondary
metabolites
with
over
200
new
compounds
isolated
each
year,
contributing
23%
approved
marine
drugs
so
far.
This
review
describes
statistical
research,
structural
diversity,
and
pharmacological
activity
sponge
derived
natural
products
from
2009
to
2018.
Approximately
2762
have
been
reported
180
genera
this
decade,
which
the
main
types
alkaloids
terpenoids,
accounting
for
50%
total.
More
than
half
molecules
showed
biological
activities
including
cytotoxic,
antibacterial,
antifungal,
antiviral,
anti-inflammatory,
antioxidant,
enzyme
inhibition,
antimalarial
activities.
As
summarized
in
review,
macrolides
peptides
had
higher
proportions
other
chemical
classes.
Every
class
displayed
cytotoxicity
as
dominant
activity.
Alkaloids
were
major
contributors
antioxidant
while
steroids
primarily
responsible
pest
resistance
Alkaloids,
most
diverse
The
statistic
research
by
published
class,
taxonomy,
presented.
Structural
novelty
significant
bioactivities
some
representative
highlighted.
rich
novel
serve
animal
hosts
microorganisms,
highlighting
undisputed
potential
development.
Biotechnology Advances,
Journal Year:
2023,
Volume and Issue:
67, P. 108205 - 108205
Published: June 24, 2023
Numerous
biotic
and
abiotic
stress
in
some
geographical
regions
predisposed
their
agricultural
matrix
to
challenges
threatening
plant
productivity,
health,
quality.
In
curbing
these
threats,
different
customary
agrarian
principles
have
been
created
through
research
development,
ranging
from
chemical
inputs
genetic
modification
of
crops
the
recently
trending
smart
technology.
But
peculiarities
associated
with
methods
made
agriculturists
rely
on
rhizospheric
microbiome
services,
particularly
bacteria.
Several
bacterial
resources
like
Proteobacteria,
Firmicutes,
Acidobacteria,
Actinomycetes
(Streptomycetes)
are
prominent
as
bioinoculants
or
application
by-products
alleviating
biotic/abiotic
extensively
studied,
a
dearth
rare
metabolites.
Rare
known
for
colossal
genome,
containing
well-preserved
genes
coding
prolific
secondary
metabolites
many
agroactive
functionalities
that
can
revolutionize
industry.
Therefore,
imperativeness
this
review
express
occurrence
distributions
diversity,
soil-associated
habitats,
successional
track
rhizosphere
under
diverse
stress,
metabolite
characteristics
remediate
productivity.
Marine Drugs,
Journal Year:
2021,
Volume and Issue:
19(6), P. 342 - 342
Published: June 15, 2021
Cancer
has
always
been
a
threat
to
human
health
with
its
high
morbidity
and
mortality
rates.
Traditional
therapy,
including
surgery,
chemotherapy
radiotherapy,
plays
key
role
in
cancer
treatment.
However,
it
is
not
able
prevent
tumor
recurrence,
drug
resistance
treatment
side
effects,
which
makes
very
attractive
challenge
search
for
new
effective
specific
anticancer
drugs.
Nature
valuable
source
of
multiple
pharmaceuticals,
most
the
drugs
are
natural
products
or
derived
from
them.
Marine-derived
compounds,
such
as
nucleotides,
proteins,
peptides
amides,
have
also
shed
light
on
they
receiving
fast-growing
interest
due
their
bioactive
properties.
Their
mechanisms
contain
anti-angiogenic,
anti-proliferative
anti-metastasis
activities;
cell
cycle
arrest;
induction
apoptosis.
This
review
provides
an
overview
development
marine-derived
compounds
properties,
both
applications
mechanisms,
discovered
technologies.
