Advanced Synthesis & Catalysis,
Journal Year:
2020,
Volume and Issue:
363(1), P. 62 - 119
Published: Oct. 31, 2020
Abstract
The
use
of
clean
and
renewable
light
sources
is
increasingly
common
in
organic
synthesis
due
to
its
safety,
practicality
economy.
Recently,
photoredox
catalysis
has
shown
great
application
values
transformations
because
advantages
environmentally
friendly
abundant
resources.
Indoles
their
derivatives
(indolines,
oxindoles
isatins)
are
the
core
skeletons
some
important
compounds
widely‐present
various
natural
products
pharmaceuticals
with
different
biological
activities.
Therefore,
research
on
modification
indoles
particularly
for
chemists
pharmacologists.
This
review
summarizes
effects
photocatalysis
indole
recent
decades.
These
accomplished
by
using
metal
photocatalysts
(
i.
e
.,
Ir,
Ru,
Ni,
Cu,
Fe,
Au,
Rh,
TiO
2
,
etc.)
or
non‐metallic
Rose
Bengal,
Eosin
Y,
quinones,
naphthols,
N‐heterocyclic
carbenes,
carbazoles,
pyrylium
salts,
etc.),
without
need
photocatalysts.
detailed
mechanisms
these
photo‐catalyzed/promoted
reactions
also
highlighted
deeply.
And
we
hope
this
will
be
helpful
researchers
interested
promising
field
photocatalyzed
transformations.
magnified
image
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(14), P. 3515 - 3521
Published: Jan. 1, 2023
A
mild
and
simple
electrochemical
system
has
been
developed
for
the
efficient
cyclization
of
2-ethynylanilines
to
selectively
access
3-iodoindoles
or
indoles.
Science Advances,
Journal Year:
2024,
Volume and Issue:
10(19)
Published: May 10, 2024
Atropisomeric
indoles
defined
by
a
N─N
axis
are
an
important
class
of
heterocycles
in
synthetic
and
medicinal
chemistry
material
sciences.
However,
they
remain
heavily
underexplored
due
to
limited
methods
challenging
stereocontrol
over
the
short
bonds.
Here,
we
report
highly
atroposelective
access
axially
chiral
via
asymmetric
Larock
reaction.
This
protocol
leveraged
powerful
role
phosphoramidite
ligand
attenuate
common
dissociation
original
reaction,
forming
with
excellent
functional
group
tolerance
high
enantioselectivity
palladium-catalyzed
intermolecular
annulation
between
readily
available
o
-iodoaniline
alkynes.
The
multifunctionality
prepared
allowed
diverse
post-coupling
transformations,
affording
broad
array
functionalized
indoles.
Experimental
computational
studies
have
been
conducted
explore
reaction
mechanism,
elucidating
enantio-determining
rate-limiting
steps.
Current Research in Pharmacology and Drug Discovery,
Journal Year:
2022,
Volume and Issue:
3, P. 100119 - 100119
Published: Jan. 1, 2022
Indole-containing
small
molecules
have
been
reported
to
diverse
pharmacological
activities.
The
aromatic
heterocyclic
scaffold,
which
resembles
various
protein
structures,
has
received
attention
from
organic
and
medicinal
chemists.
Exploration
of
indole
derivatives
in
drug
discovery
rapidly
yielded
a
vast
array
biologically
active
compounds
with
broad
therapeutic
potential.
Nature
is
the
major
source
scaffolds,
but
classical
advanced
synthesis
methods
for
indoles
also
reported.
One-pot
widely
considered
an
efficient
approach
synthetic
chemistry
used
synthesize
some
compounds.
rapid
emergence
drug-resistant
tuberculosis
challenge
be
addressed.
Identifying
novel
targets
candidates
therefore
crucial.
Researchers
extensively
explored
as
potential
anti-tubercular
agents
or
drugs.
Indole
scaffolds
containing
non-covalent
(decaprenylphosphoryl-β-D-ribose2'-epimerase)
DprE1
inhibitor
1,4-azaindole
currently
clinical
trials
treat
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: April 28, 2022
Abstract
Photosensitization
of
organogold
intermediates
is
an
emerging
field
in
catalysis.
In
this
context,
access
to
2,3-disubstituted
indoles
from
o
-alkynyl
aniline
and
iodoalkyne
derivatives
via
a
gold-catalyzed
sequence
under
visible-light
irradiation
the
absence
exogenous
photocatalyst
was
uncovered.
A
wide
scope
process
observed.
Of
note,
2-iodo-ynamides
can
be
used
as
electrophiles
cross-coupling
reaction.
The
resulting
N
lend
themselves
post-functionalization
affording
valuable
scaffolds,
notably
benzo[a]carbazoles.
Mechanistic
studies
converge
on
fact
that
potassium
sulfonyl
amide
generates
emissive
aggregates
reaction
medium.
Static
quenching
these
by
vinylgold(I)
intermediate
yields
excited
state
latter,
which
react
with
electrophile
oxidative
addition
reductive
elimination
forge
key
C-C
bond.
This
reactant-induced
photoactivation
opens
rich
perspectives
reactions.
Organic & Biomolecular Chemistry,
Journal Year:
2023,
Volume and Issue:
21(44), P. 8918 - 8923
Published: Jan. 1, 2023
An
efficient
electrochemical
selenocyclization
strategy
for
the
synthesis
of
3-selenylindoles
from
2-ethynylanilines
and
diselenides
has
been
developed
in
simple
tube-
or
beaker-type
undivided
cells
under
ambient
conditions.
Notably,
these
sustainable
transformations
are
completed
within
a
short
time
with
low
equivalents
charges,
electrolytes,
exhibiting
broad
substrate
scope
excellent
functional
group
compatibility.
Moreover,
gram-scale
electrosynthesis
late-stage
functionalization
complex
molecules
further
demonstrate
practical
synthetic
potential
this
facile
system.
Organic
and
inorganic
compounds
are
widely
used
as
corrosion
inhibitors.
It
is
important
to
mention
that
most
of
the
toxic
non-environmental
friendly;
therefore,
their
current
use
inhibitors
strictly
inhibited
because
increasing
ecological
awareness
strict
environmental
regulations.
Most
organic
become
effective
by
adsorbing
on
metallic
surface.
Adsorption
mostly
follows
Langmuir
adsorption
isotherm
model.
Polar
functional
groups
multiple
bonds
act
centers
during
metal
inhibitor
interactions.
Present
chapter
deals
with
comparison
various
aspects
inhibition
using
Asian Journal of Organic Chemistry,
Journal Year:
2021,
Volume and Issue:
10(6), P. 1282 - 1318
Published: April 1, 2021
Abstract
This
review
is
intended
to
highlight
the
most
useful
approaches
for
synthesis
of
indole
derivatives
(azaindoles,
carbazoles,
carbolines,
indazoles,
3
H
‐indoles,
indolines,
indolizines,
isoindoles,
and
isoindolines),
which
were
described
by
using
transition‐metal
catalyzed
cyclization
reactions
alkynes
nitrogen
compounds.
The
methodologies
carried
out
under
metal‐free
conditions
will
also
be
illustrated
herein.
cover
data
published
mostly
in
past
decade.
Asian Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
11(2)
Published: Jan. 5, 2022
Abstract
2‐Alkynylanilines
as
versatile
building
blocks
have
been
widely
applied
for
the
construction
of
nitrogen
atom‐containing
heterocycles
in
organic
synthesis.
The
focus
this
review
is
on
application
2‐alkynylaniline
and
its
derivatives
metal‐catalyzed
or
metal‐free
synthesis
various
including
indoles,
oxindoles,
indazoles,
benzisoxazoles,
quinolines,
benzoxazines,
benzothiazines,
quinazolines,
cinnolines,
seven‐
eight‐membered
heterocycles.
