Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(21), P. 7461 - 7503
Published: Jan. 1, 2023
Over
the
past
few
decades,
advent
of
C–H
activation
has
led
to
a
rethink
among
chemists
about
synthetic
strategies
employed
for
multi-step
transformations.
Organic Chemistry Frontiers,
Journal Year:
2021,
Volume and Issue:
8(16), P. 4582 - 4606
Published: Jan. 1, 2021
Functionalized
cyclic
amines
are
the
essential
structural
moieties
of
numerous
biologically
active
compounds.
This
review
summarized
most
recent
advances
in
C–H,
C–N
and
C–C
bond
functionalization
saturated
amines.
Organic Chemistry Frontiers,
Journal Year:
2022,
Volume and Issue:
9(18), P. 5041 - 5052
Published: Jan. 1, 2022
This
review
highlights
the
encouraging
advances
in
hydride
transfer-involved
dearomatization
reaction
during
past
decade,
content
of
which
is
categorized
according
to
acceptors,
namely
vinylogous
imines
and
quinone
methides.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(14), P. 2432 - 2437
Published: April 5, 2023
An
unprecedented
hydride
transfer-triggered
cross-dehydrogenative
coupling
of
two
C(sp3)-H
bonds
to
target
nine-membered
rings
has
been
developed.
Salient
features
this
methodology
include
atom
and
step
economy
metal-free
redox-neutral
conditions,
with
water
as
the
byproduct
proceeding
well
even
decomposed
aldehydes.
Science,
Journal Year:
2024,
Volume and Issue:
384(6697), P. 815 - 820
Published: May 16, 2024
Generally,
the
acidity
of
carbon-hydrogen
bonds
is
most
sensitive
to
functionality
just
one
or
two
away.
Here,
we
present
an
approach
formation
carbon-carbon
σ
by
remote
proton
elimination,
a
distinct
mode
activation
enabled
distal
acidification
through
five
bonds.
Application
elimination
cyclodecyl
cations
unveiled
appealing
method
for
synthesis
decalins.
The
transformation
regioconvergent,
proceeds
without
need
directing
group
precious
metal,
and
demonstrates
exquisite
site
selectivity.
An
in-depth
computational
study
illuminated
reaction
mechanism.
Additionally,
describe
complete
stereoisomeric
enrichment
decalin
products
epimerization
mediated
hydrogen
atom
transfer.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(9), P. 1824 - 1827
Published: Feb. 28, 2024
A
synthetic
strategy
for
forming
multisubstituted
naphthalenes
based
on
hydride
shift
mediated
C(sp3)–H
bond
functionalization
was
developed.
This
consists
of
three
successive
transformations:
(1)
an
intramolecular
functionalization;
(2)
a
decarboxylative
fragmentation;
and
(3)
oxidation
reaction.
When
benzylidene
malonates
having
2-alkoxyethyl
group
at
the
ortho
position
were
treated
with
catalytic
amount
Al(OTf)3,
shift/cyclization
reaction
proceeded
smoothly
to
afford
tetralin
derivatives
in
good
chemical
yields.
The
resulting
tetralins
easily
converted
into
by
exposing
them
modified
Krapcho
decarboxylation
conditions
(LiCl,
DMSO,
heating
under
O2
atmosphere).
one-pot
operation
these
two
reactions
also
realized.
Bulletin of the Chemical Society of Japan,
Journal Year:
2022,
Volume and Issue:
95(2), P. 296 - 305
Published: Jan. 12, 2022
Abstract
An
efficient
catalytic
internal
redox
reaction
(hydride
shift
mediated
C(sp3)–H
bond
functionalization)
has
been
developed,
which
the
following
salient
features:
(1)
functionalization,
(2)
Lewis
and/or
Brønsted
acid
catalyzed
(transition
metals
employed
in
conventional
C–H
functionalization
are
not
required),
and
(3)
construction
of
complex
polycycles
that
otherwise
difficult
to
synthesize
by
methods.
Our
recent
efforts
on
development
novel
types
hydride
shift/cyclization
system
described.
