The Chemical Record,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 21, 2025
The
exploration
of
macrocycles
began
in
the
20th
century,
coinciding
with
progressive
advancement
synthetic
chemistry
methodologies.
From
numerous
strategies,
Ugi
reaction
stands
out
as
an
efficacious
four-component
(4-CR).
is
particularly
distinguished
by
its
robust
functional
group
tolerance,
enabling
creation
that
are
both
diverse
and
complex
a
singular
step.
This
review
collates
contemporary
examples
macrocycles,
all
which
have
been
crafted
using
to
construct
these
macrocyclic
frameworks.
employment
various
bifunctional
reagents
(with
same
or
different
groups),
has
introduced
plethora
cyclization
tactics,
resulting
synthesis
multitude
cage
molecules.
In
order
offer
invaluable
insights
into
construction
use
distinct
colors
for
reactants
made
entire
process
transparently
visible,
thereby
enhancing
readers'
understanding
sparking
their
interest.
ACS Medicinal Chemistry Letters,
Journal Year:
2023,
Volume and Issue:
14(4), P. 376 - 385
Published: March 8, 2023
The
generation
of
multiple
bonds
in
one
reaction
step
has
attracted
massive
interest
drug
discovery
and
development.
Multicomponent
reactions
(MCRs)
offer
the
advantage
combining
three
or
more
reagents
a
one-pot
fashion
to
effectively
yield
synthetic
product.
This
approach
significantly
accelerates
synthesis
relevant
compounds
for
biological
testing.
However,
there
is
perception
that
this
methodology
will
only
produce
simple
chemical
scaffolds
with
limited
use
medicinal
chemistry.
In
Microperspective,
we
want
highlight
value
MCRs
toward
complex
molecules
characterized
by
presence
quaternary
chiral
centers.
paper
cover
specific
examples
showing
impact
technology
clinical
recent
breakthroughs
expand
scope
topologically
rich
molecular
chemotypes.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(11), P. 6230 - 6239
Published: March 9, 2023
The
library
of
imine-linked
covalent
organic
frameworks
(COFs)
has
grown
significantly
over
the
last
two
decades,
featuring
a
variety
morphologies,
pore
sizes,
and
applications.
An
array
synthetic
methods
been
developed
to
expand
scope
COF
functionalities;
however,
most
these
were
designed
introduce
functional
scaffolds
tailored
specific
application.
Having
general
approach
diversify
COFs
via
late-stage
incorporation
group
handles
would
greatly
facilitate
transformation
materials
into
platforms
for
useful
Herein,
we
report
strategy
in
Ugi
multicomponent
reaction.
To
demonstrate
versatility
this
approach,
have
synthesized
with
hexagonal
kagome
morphologies.
We
then
introduced
azide,
alkyne,
vinyl
groups,
which
could
be
readily
utilized
post-synthetic
modifications.
This
facile
enables
functionalization
any
containing
imine
linkages.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(7), P. 6581 - 6581
Published: April 1, 2023
Multicomponent
reactions
(MCRs)
have
emerged
as
a
powerful
strategy
in
synthetic
organic
chemistry
due
to
their
widespread
applications
drug
discovery
and
development.
MCRs
are
flexible
transformations
which
three
or
more
substrates
react
form
structurally
complex
products
with
high
atomic
efficiency.
They
being
increasingly
appreciated
highly
exploratory
evolutionary
tool
by
the
medicinal
community,
opening
door
sustainable,
cost-effective
rapid
synthesis
of
biologically
active
molecules.
In
recent
years,
MCR-based
strategies
found
extensive
application
field
discovery,
several
anticancer
drugs
been
synthesized
through
MCRs.
this
review,
we
present
an
overview
representative
literature
examples
documenting
different
approaches
development
new
drugs.
The Journal of Organic Chemistry,
Journal Year:
2021,
Volume and Issue:
86(20), P. 13857 - 13872
Published: June 14, 2021
Microwave-assisted
organic
synthesis
has
been
widely
studied
and
deliberated,
opening
up
some
controversial
issues
as
well.
Nowadays,
microwave
chemistry
is
a
mature
technology
that
well
demonstrated
in
many
cases
with
numerous
advantages
terms
of
the
reaction
rate
yield.
The
strategies
toward
scaling
find
an
ally
continuous-flow
reactor
comparing
dielectric
conductive
heating.
Pharmaceuticals,
Journal Year:
2022,
Volume and Issue:
15(8), P. 1009 - 1009
Published: Aug. 17, 2022
Multicomponent
reactions
9i.e.,
those
that
engage
three
or
more
starting
materials
to
form
a
product
contains
significant
fragments
of
all
them),
have
been
widely
employed
in
the
construction
compound
libraries,
especially
context
diversity-oriented
synthesis.
While
relatively
less
exploited,
their
use
target-oriented
synthesis
offers
advantages
terms
synthetic
efficiency.
This
review
provides
critical
summary
multicomponent
for
preparation
active
pharmaceutical
principles.
Russian Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
92(12), P. RCR5104 - RCR5104
Published: Dec. 1, 2023
After
the
appearance
of
green
chemistry
concept,
which
was
introduced
in
vocabulary
early
1990s,
its
main
statements
have
been
continuously
developed
and
modified.
Currently,
there
are
10–12
cornerstones
that
should
form
basis
for
an
ideal
chemical
process.
This
review
analyzes
accumulated
experience
achievements
towards
design
products
processes
reduce
or
eliminate
use
generation
hazardous
substances.
The
presents
views
leading
Russian
scientists
specializing
various
fields
this
subject,
including
homogeneous
heterogeneous
catalysis,
fine
basic
organic
synthesis,
electrochemistry,
polymer
chemistry,
based
on
bio-renewable
feedstocks
energetic
compounds
materials.
A
new
approach
to
quantitative
evaluation
environmental
friendliness
by
authors
is
described.
<br>
bibliography
includes
1761.
Organic & Biomolecular Chemistry,
Journal Year:
2023,
Volume and Issue:
21(17), P. 3477 - 3502
Published: Jan. 1, 2023
This
review
article
presents
an
in-depth
analysis
of
the
strategies
and
methodologies
for
using
chiral
phosphoric
acids
as
organocatalysts
in
asymmetric
syntheses
from
recent
literature.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(4), P. 4246 - 4262
Published: Jan. 17, 2024
Alginates
are
linear
anionic
polysaccharides,
which
well-known
for
their
biocompatible,
nontoxic,
and
biodegradable
nature.
The
polymer
consists
of
alternating
units
β-(1
→
4)-linked
D-mannuronic
acid
(M)
α-(1
L-guluronic
(G)
that
have
hydroxyl
carboxyl
groups
as
the
main
functional
groups.
As
a
large
number
free
present
in
polymeric
chain,
is
predominantly
hydrophilic.
food
pharmaceutical
industries
been
most
extensive
utilizers
alginates
to
produce
gelling
thickening
agents.
However,
by
imparting
hydrophobicity
alginates,
range
applications
can
be
widened.
Although
there
reviews
on
alginate
its
chemical
modifications,
focusing
hydrophobically
associated
not
presented.
commonly
used
modifications
incorporate
include
esterification,
Ugi
reaction,
reductive
amination,
graft
copolymerization.
modified
play
an
important
role
delivery
hydrophobic
drugs
pesticides
modification
increases
affinity
toward
components
helps
sustained
release.
Due
nontoxic
edible
nature,
they
find
use
industry
emulsion
stabilizer
stabilize
oil-in-water
emulsions
improve
creaming
ability.
Further,
alginate-based
materials
such
membranes,
aerogels,
films
functionality
applicability
water
treatment
packaging.
This
Review
aims
highlight
methods
done
impart
alginate,
different
sectors
ranging
from
drug
packaging
discussed.
