The Chemical Record,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 21, 2025
The
exploration
of
macrocycles
began
in
the
20th
century,
coinciding
with
progressive
advancement
synthetic
chemistry
methodologies.
From
numerous
strategies,
Ugi
reaction
stands
out
as
an
efficacious
four-component
(4-CR).
is
particularly
distinguished
by
its
robust
functional
group
tolerance,
enabling
creation
that
are
both
diverse
and
complex
a
singular
step.
This
review
collates
contemporary
examples
macrocycles,
all
which
have
been
crafted
using
to
construct
these
macrocyclic
frameworks.
employment
various
bifunctional
reagents
(with
same
or
different
groups),
has
introduced
plethora
cyclization
tactics,
resulting
synthesis
multitude
cage
molecules.
In
order
offer
invaluable
insights
into
construction
use
distinct
colors
for
reactants
made
entire
process
transparently
visible,
thereby
enhancing
readers'
understanding
sparking
their
interest.
Beilstein Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
21, P. 444 - 450
Published: Feb. 26, 2025
A
new
tandem
sequence
involving
the
Ugi
reaction
and
Diels-Alder
[4
+
2]
cycloaddition
based
on
vinylfuran
1,3-butadienylfuran
derivatives
was
designed
studied.
It
found
that
in
case
of
3-(furan-2-yl)acrylaldehyde,
a
one-pot
intramolecular
vinylarene
(IMDAV)
leads
to
formation
insufficiently
studied
furo[2,3-f]isoindole
derivatives.
adducts
formed
from
(E)-3-(furan-2-yl)acrylaldehyde,
maleic
acid
monoanilide,
isonitrile,
an
amine
spontaneously
underwent
IMDAV
with
high
level
stereoselectivity,
leading
single
pairs
enantiomers
4,4a,5,6,7,7a-hexahydro-3aH-furo[2,3-f]isoindole
core
excellent
yields.
Under
same
conditions,
(2E,4E)-5-(furan-2-yl)penta-2,4-dienal
gives
adduct
undergoes
IMDA
without
furan
core.
The
2,3,3a,4,5,7a-hexahydro-1H-isoindoles
reactions
allow
substituent
variation
named
isoindoles.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 13, 2025
The
enol-Ugi
condensation,
a
versatile
multicomponent
reaction,
provides
rapid
and
efficient
route
to
enamine
peptidomimetics.
In
this
study,
we
investigated
the
factors
influencing
conformational
behavior
of
three
adducts
with
distinct
structural
features.
Through
DFT
calculations
NCI
analysis,
identified
that
noncovalent
interactions,
including
hydrogen
bonds
π–π
play
pivotal
role
in
restricting
flexibility.
While
six-membered
cyclic
enamines
6
7
exhibited
varying
degrees
rotational
freedom,
indanone-derived
8
displayed
locked
conformation
resembling
retropeptidic
turn.
These
findings
highlight
potential
tailoring
mimic
biologically
relevant
peptidic
motifs,
opening
new
avenues
for
drug
discovery
design.
The Chemical Record,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 21, 2025
The
exploration
of
macrocycles
began
in
the
20th
century,
coinciding
with
progressive
advancement
synthetic
chemistry
methodologies.
From
numerous
strategies,
Ugi
reaction
stands
out
as
an
efficacious
four-component
(4-CR).
is
particularly
distinguished
by
its
robust
functional
group
tolerance,
enabling
creation
that
are
both
diverse
and
complex
a
singular
step.
This
review
collates
contemporary
examples
macrocycles,
all
which
have
been
crafted
using
to
construct
these
macrocyclic
frameworks.
employment
various
bifunctional
reagents
(with
same
or
different
groups),
has
introduced
plethora
cyclization
tactics,
resulting
synthesis
multitude
cage
molecules.
In
order
offer
invaluable
insights
into
construction
use
distinct
colors
for
reactants
made
entire
process
transparently
visible,
thereby
enhancing
readers'
understanding
sparking
their
interest.
