Multicomponent
reactions
(MCRs)
provide
an
alternative
scheme
for
target
synthesis,
by
allowing
fast
and
efficient
synthetic
access
based
on
its
"one-pot"
character,
accessing
almost
unlimited
scaffold
diversity,
fostering
a
very
large
chemical
space
simple
building
blocks
available
in
numerous
derivatives,
addressing
challenging
issues
of
sustainability
("green
chemistry").
Hence,
MCR
can
be
potentially
useful
the
discovery
synthesis
biologically
active
"drug-like"
compounds.
Here,
we
highlight
examples
use
medicinal
chemistry,
from
drug
discovery,
drugs,
to
screening
libraries
biopharmaceutical
applications.
The
review
is
not
comprehensive
but
rather
personal
selection
authors
reader
overview
advantages
usefulness
MCR.
We
conclude
that
literature
analysis,
toto
,
supports
highly
underused
role
chemistry.
ChemistrySelect,
Journal Year:
2022,
Volume and Issue:
7(47)
Published: Dec. 14, 2022
Abstract
Multicomponent
reactions
(MCRs)
have
emerged
as
key
green
tool
in
organic
synthesis
for
their
methodological
simplicity.
MCRs
made
heterocycle
more
versatile.
The
most
crucial
molecule
among
the
often
used
heterocycles
is
pyridine,
which
widely
biological,
industrial,
and
pharmaceutical
sectors.
In
light
of
this,
our
mini‐review
highlights
literature
on
substituted
pyridine
published
from
year
2016
to
early
2022
via
multicomponent
approach.
Synthetic Communications,
Journal Year:
2023,
Volume and Issue:
53(5), P. 345 - 375
Published: Feb. 3, 2023
1,2,3-Triazoles
has
emerged
as
one
of
the
most
important
N-heterocyclic
compounds
with
a
broad
range
pharmacological
applications.
This
class
molecules
can
accommodate
wide
substituents
or
groups
around
core
moiety
that
pave
mode
for
synthesis
various
bioactive
compounds.
Copper(I)-catalyzed
azide-alkyne
cycloaddition
reaction
become
leading
click
chemistry
methodologies
due
to
its
high
biocompatibility,
reliability,
and
specificity.
1,4-Disubstituted
1,2,3-triazoles
via
multicomponent
generated
numerous
biological
interest
in
an
efficient
manner.
review
summarizes
recent
literature
on
regioselective
1,4-disubstituted
copper-catalyzed
reactions
since
2018.
Beilstein Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
21, P. 200 - 216
Published: Jan. 22, 2025
Over
the
past
decade,
dioxazolones
have
been
widely
used
as
N
-acylamide
sources
in
amidation
processes
of
challenging
substrates,
typically
employing
precious
transition
metals.
However,
these
catalytic
systems
often
present
several
challenges
associated
with
cost,
toxicity,
stability,
and
recyclability.
Among
3d
metals,
copper
catalysts
gaining
increasing
attention
owing
to
their
abundance,
cost-effectiveness,
sustainability.
Recently,
applied
chemical
transformation
dioxazolones,
conferring
a
convenient
protocol
towards
amidated
products.
This
review
highlights
recent
advancements
synthetic
transformations
particular
examples
salts.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 27, 2025
A
mild
CuI-catalyzed
dearomatization/peroxidation/cyclization
cascade
of
pyrrole-tethered
indoles
has
been
reached,
providing
peroxide-incorporated
indolizino[8,7-b]indole
derivatives
in
acceptable
to
good
yields
(46–76%).
Dehydrogenated
peroxide
can
be
obtained
by
the
use
a
FeCl3/TBHP
(tBuOOH)/2,2,2-trifluoroethanol
(TFE)
system
at
50
°C.
Herein,
we
report
an
efficient
methodology
for
the
preparation
of
a
heterogeneous
sustainable
magnetically
separable
Cu@PANI@Fe
3
O
4
nanocomposite,
and
its
catalytic
efficiency
in
multicomponent
reactions
synthesis
triazolo
quinolines
triazolyl
benzamide
derivatives
is
investigated.
Medicinal Chemistry,
Journal Year:
2022,
Volume and Issue:
18(10), P. 1013 - 1043
Published: March 26, 2022
In
the
last
several
decades,
interest
in
pyrrole
and
pyrrolopyrimidine
derivatives
has
increased
owing
to
their
biological
importance,
such
as
anti-tumor,
anti-microbial,
anti-inflammatory,
anti-diabetic,
anti-histaminic,
anti-malarial,
anti-Parkinson,
antioxidant
anti-viral
effects,
specially
recently
against
COVID-19.
These
tremendous
features
have
motivated
scientists
discover
more
fused
derivatives,
great
importance
of
nucleus
a
pharmacophore
many
drugs,
us
present
this
article,
highlighting
on
different
synthetic
pathways
its
compounds,
pyrrolopyrimidine,
well
medicinal
value
from
2017
till
2021.
