ChemPhotoChem,
Journal Year:
2020,
Volume and Issue:
5(4), P. 296 - 314
Published: Dec. 4, 2020
Abstract
Photopharmacological
tools
enable
the
precise
spatiotemporal
control
of
small
molecule
drugs.
Amongst
them,
caged
compounds
incorporate
a
photolabile
moiety
which
is
released
under
illumination,
thus
liberating
active
molecule.
Caging
groups
have
long
been
known
and
many
chemical
scaffolds
already
used
in
different
applications.
However,
most
initial
examples
are
cleaved
with
UV
light,
suffers
from
low
tissue
permeability
cell
damage.
Recently,
caging
that
visible
light
reported,
expand
their
utility.
In
this
review,
we
outline
strategies
to
increase
absorption
wavelengths;
compare
photophysical
properties,
discuss
synthetic
accessibility,
exemplify
some
biological
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(22), P. 12377 - 12449
Published: Jan. 1, 2021
Molecular
photoswitches
are
inherently
lipophilic
and
do
not
spontaneously
dissolve
in
water.
We
describe
the
effect
of
water
on
photochemical
properties
strategies
to
solubilize
organic
apply
them
aqueous
media.
Chemical Science,
Journal Year:
2021,
Volume and Issue:
12(45), P. 14964 - 14986
Published: Jan. 1, 2021
Various
families
of
light-driven
rotary
molecular
motors
and
the
key
aspects
motor
design
are
discussed.
Comparisons
made
between
strengths
weaknesses
each
motor.
Challenges,
applications,
future
prospects
explored.
Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
61(31)
Published: May 7, 2022
Abstract
Light
offers
unique
opportunities
for
controlling
the
activity
of
materials
and
biosystems
with
high
spatiotemporal
resolution.
Molecular
photoswitches
are
chromophores
that
undergo
reversible
isomerization
between
different
states
upon
irradiation
light,
allowing
a
convenient
means
to
control
their
influence
over
system
interest.
However,
significant
limitation
classical
is
requirement
initiate
switching
in
one
or
both
directions
using
deleterious
UV
light
poor
tissue
penetration.
Red‐shifted
hence
demand
have
attracted
keen
recent
research
In
this
Review,
we
highlight
progress
towards
development
visible‐
NIR‐activated
characterized
by
distinct
photochromic
reaction
mechanisms.
We
hope
inspire
further
endeavors
field,
full
potential
these
tools
biotechnology
chemistry
applications
be
realized.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(30)
Published: April 7, 2023
Photopharmacology
is
an
attractive
approach
for
achieving
targeted
drug
action
with
the
use
of
light.
In
photopharmacology,
molecular
photoswitches
are
introduced
into
structure
biologically
active
small
molecules
to
allow
optical
control
their
potency.
Going
beyond
trial
and
error,
photopharmacology
has
progressively
applied
rational
design
methodologies
devise
light-controlled
bioactive
ligands.
this
review,
we
categorize
photopharmacological
efforts
from
standpoint
medicinal
chemistry
strategies,
focusing
on
diffusible
photochromic
ligands
modified
that
operate
through
E-Z
bond
isomerization.
vast
majority
cases,
photoswitchable
designed
as
analogs
existing
compounds,
a
variety
approaches.
By
analyzing
in
detail
comprehensive
list
instructive
examples,
describe
state
art
discuss
future
opportunities
photopharmacology.
European Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
2022(19)
Published: Feb. 26, 2022
Abstract
Molecular
photoswitches
reversibly
convert
the
energy
of
light
into
a
variety
structural
changes
at
molecular
level.
They
can
be
integrated
smart
materials
with
broad
range
applicability.
While
most
photochromic
systems
require
UV
for
activation,
application
operational
entirely
within
visible
or
NIR
brings
considerable
benefits,
such
as
biocompatibility,
better
penetration
through
material,
propelling
sunlight,
possibility
to
design
dual
that
are
mutually
activated
frequencies
two
distinct
functions.
In
this
Review,
we
discuss
relevant
classes
photoswitches,
and
demonstrate
selection
polymers,
gels,
porous
materials,
surfaces,
energy‐storing
other
triggered
light.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(23), P. 8245 - 8294
Published: Jan. 1, 2023
Donor-acceptor
Stenhouse
adduct
(DASA)
photoswitches
have
gained
a
lot
of
attention
since
their
discovery
in
2014.
Their
negative
photochromism,
visible
light
absorbance,
synthetic
tunability,
and
the
large
property
changes
between
photoisomers
make
them
attractive
candidates
over
other
commonly
used
for
use
materials
with
responsive
or
adaptive
properties.
The
development
such
translation
into
advanced
technologies
continues
to
widely
impact
forefront
research,
DASAs
thus
attracted
considerable
interest
field
visible-light
molecular
switches
dynamic
materials.
Despite
this
interest,
there
been
challenges
understanding
complex
behavior
context
both
small
molecule
studies
Moreover,
incorporation
polymers
can
be
challenging
due
incompatibility
conditions
most
common
polymerization
techniques.
In
review,
therefore,
we
examine
critically
discuss
recent
developments
DASA-containing
polymers,
aiming
at
providing
better
interplay
properties
constituents
(matrix
photoswitch).
first
part
summarizes
current
DASA
design
switching
second
section
discusses
strategies
materials,
methods
studying
We
also
emerging
applications
polymeric
ranging
from
light-responsive
drug
delivery
systems,
photothermal
actuators,
sensors
photoswitchable
surfaces.
Last,
summarize
venture
on
steps
required
explore
novel
systems
expand
functional
application
opportunities
polymers.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(16), P. 9072 - 9080
Published: April 12, 2023
A
novel
class
of
photoswitches
based
on
a
phenylazothiazole
scaffold
that
undergoes
reversible
isomerization
under
visible-light
irradiation
is
reported.
The
photoswitch,
which
comprises
thiazole
heteroaryl
segment
directly
connected
to
phenyl
azo
chromophore,
has
very
different
spectral
characteristics,
such
as
redshifted
absorption
maximum
wavelength
and
well-separated
bands
the
trans
cis
isomers,
than
conventional
azobenzene
other
compounds.
Substituents
at
ortho
para
positions
ring
photoswitch
resulted
in
further
shift
longer
wavelengths
up
525
nm
with
small
thermal
stability
compensation.
These
showed
excellent
photostationary
distributions
half-lives
7.2
h,
reductant
stability.
X-ray
crystal
structure
analysis
revealed
isomers
exhibited
planar
geometry
T-shaped
orthogonal
geometry.
Detailed
ab
initio
calculations
demonstrated
plausible
electronic
transitions
energy
barriers,
were
consistent
experimental
observations.
fundamental
design
principles
elucidated
this
study
will
aid
development
wide
variety
for
photopharmacological
applications.
