Deacylative arylation and alkynylation of unstrained ketones DOI Creative Commons
B. L. Zhang,

Hui Bai,

Bei‐Bei Zhan

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(17)

Published: April 26, 2024

Ketones are ubiquitous in bioactive natural products, pharmaceuticals, chemical feedstocks, and synthetic intermediates. Hence, deacylative coupling reactions enable the versatile elaboration of a plethora chemicals to access complex drug candidates products. Here, we present arylation alkynylation strategies for synthesis wide range alkyl-tethered arenes alkynes from cyclic ketones methyl under dual nickel/photoredox catalysis. This reaction begins by generating pre-aromatic intermediate (PAI) through condensation ketone

Language: Английский

Electrochemical generation and utilization of alkoxy radicals DOI Creative Commons

Albara A. M. A. El Gehani,

Hussain A. Maashi,

James Harnedy

et al.

Chemical Communications, Journal Year: 2023, Volume and Issue: 59(25), P. 3655 - 3664

Published: Jan. 1, 2023

This highlight summarises electrochemical approaches for the generation and utilization of alkoxy radicals, predominantly focusing on recent advances (2012–present).

Language: Английский

Citations

23
Aromatization-driven deconstructive functionalization of spiro dihydroquinazolinones via dual photoredox/nickel catalysis DOI Creative Commons

Hong-Jie Miao,

Jinhua Zhang, Wenke Li

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: 15(23), P. 8993 - 8999

Published: Jan. 1, 2024

The aromatization-driven deconstructive coupling of spiro carbocycles with organic halides via dual photoredox/nickel catalysis is developed. An in-depth mechanism study revealed that this reaction proceeded a radical-metal crossover pathway.

Language: Английский

Citations

16
Electro-reductive carboxylation of acyclic C(sp3)–C(sp3) bonds in aromatic hydrocarbons with CO2 DOI

Chuan‐Kun Ran,

Quan Qu,

Yang-Yi Tao

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: 67(10), P. 3366 - 3372

Published: Aug. 16, 2024

Language: Английский

Citations

10
Ligand-to-Metal Charge Transfer (LMCT) Catalysis: Harnessing Simple Cerium Catalysts for Selective Functionalization of Inert C–H and C–C Bonds DOI Creative Commons
Qing An, Liang Chang, Hui Pan

et al.

Accounts of Chemical Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 18, 2024

ConspectusChemists have long pursued harnessing light energy and photoexcitation processes for synthetic transformations. Ligand-to-metal charge transfer (LMCT) in high-valent metal complexes often triggers bond homolysis, generating oxidized ligand-centered radicals reduced centers. While photoinduced oxidative activations can be enabled, this process, typically seen as photochemical decomposition, remains underexplored catalytic applications. To mitigate decomposition during LMCT excitation, we developed a cycle integrating situ coordination, LMCT, ligand homolysis to activate ligated alcohols transiently into alkoxy radicals. This approach leverages Ce(IV) excitation highly reactive radical intermediates selective functionalizations of C(sp

Language: Английский

Citations

10
Deacylative arylation and alkynylation of unstrained ketones DOI Creative Commons
B. L. Zhang,

Hui Bai,

Bei‐Bei Zhan

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(17)

Published: April 26, 2024

Ketones are ubiquitous in bioactive natural products, pharmaceuticals, chemical feedstocks, and synthetic intermediates. Hence, deacylative coupling reactions enable the versatile elaboration of a plethora chemicals to access complex drug candidates products. Here, we present arylation alkynylation strategies for synthesis wide range alkyl-tethered arenes alkynes from cyclic ketones methyl under dual nickel/photoredox catalysis. This reaction begins by generating pre-aromatic intermediate (PAI) through condensation ketone

Language: Английский

Citations

9