Synthesis of a Pyrrolo[1,2-a]quinazoline-1,5-dione Derivative by Mechanochemical Double Cyclocondensation Cascade DOI Creative Commons

Vanessza Judit Kolcsár,

György Szőllősi

Molecules, Journal Year: 2022, Volume and Issue: 27(17), P. 5671 - 5671

Published: Sept. 2, 2022

N-heterocyclic compounds, such as quinazolinone derivatives, have significant biological activities. Nowadays, the demand for environmentally benign, sustainable processes increases, application of compounds from renewable sources, easily separable heterogeneous catalysts and efficient, alternative activation methods is great importance. In this study, we developed a convenient, green procedure preparation 3a-methyl-2,3,3a,4-tetrahydropyrrolo[1,2-a]quinazoline-1,5-dione through double cyclocondensation cascade using anthranilamide ethyl levulinate. Screening various Brønsted acid showed that Amberlyst® 15 convenient choice. By applying mechanochemical in N-heterotricyclic compound first time, it was possible to shorten necessary time three hours compared 24 h needed under conventional conditions obtain high yield target product.

Language: Английский

Facile Synthesis of Nanoarchitectured Hydrotalcite/SBA-15 Composites for the Efficient Conversion of Levulinic Acid to Ethyl Levulinate DOI

Marimuthu Manikandan,

P. Sangeetha

Silicon, Journal Year: 2021, Volume and Issue: 14(6), P. 3119 - 3124

Published: April 8, 2021

Language: Английский

Citations

4
Green synthetic approaches in organophosphorus chemistry: recent developments DOI
Goutam Brahmachari

Royal Society of Chemistry eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 287 - 298

Published: Feb. 21, 2024

Organophosphorus chemistry is a broad and exciting field, with potential opportunities for researchers involved in multi-disciplinary areas of scientific endeavour, including organic, medicinal, pharmaceutical, agricultural, industrial chemistry. compounds find extensive applications all these fields owing to their inherent physical biological properties. Since its first development the 90s, green sustainable has grown considerably over past two decades. It become much more prevalent among working branches chemical science. As part noteworthy developments, synthetic organic chemists have been motivated develop eco-friendly methodologies generating phosphorus-functionalised interest, focusing on various principles. result, considerable progress towards accomplished during last decade. In continuation our earlier contributions, this chapter also aims offer an overview such developments approaches organophosphorus reported 2021.

Language: Английский

Citations

0
A Green Chemistry Approach to Catalytic Synthesis of Ethyl Levulinate DOI Open Access

Martina Sušjenka,

Fran Prašnikar,

Martina Jakovljević

et al.

Catalysts, Journal Year: 2024, Volume and Issue: 14(12), P. 842 - 842

Published: Nov. 21, 2024

Esterification of levulinic acid with ethanol was investigated using deep eutectic systems based on choline chloride and oxalic or p-toluenesulfonic as catalysts under conventional heating alternative energy inputs, namely microwave, ultrasound, mechanochemical treatment. The experiments were performed varying operating conditions such catalyst type loading, alcohol to carboxylic molar ratio, temperature, time. obtained results demonstrate the overall better catalytic performance acid-based mixture in comparison analogue. best results: conversion 76% 58%, for containing systems, respectively, 100% selectivity both cases, achieved microwave-assisted synthesis 5 wt.% excess (molar ratio 5), at 413.15 K 10 min. main advantage all activation methods studied (microwaves, ultrasounds, ball mill processing) significant reduction reaction

Language: Английский

Citations

0
OPTIMISATION OF REACTION PARAMETERS FOR THE SYNTHESIS OF SOLKETAL LEVULINATE AS POTENTIAL BIODIESEL ADDITIVE DOI Open Access
Nik Siti Mariam Nek Mat Din

Journal of Oil Palm Research, Journal Year: 2021, Volume and Issue: unknown

Published: Dec. 22, 2021

Glycerol is a major by-product of biodiesel production and finding new uses for glycerol crucial to ensure the sustainability continuance industry.Thus, transformation into ketal compounds that have potential as additive improve properties, could be an option provide outlet increasing stock.This study aims optimise transesterification reaction afford solketal levulinate ester (SoLE) in highest yield by reacting with methyl (ML).The parameters varied are type base catalyst, catalyst concentration, temperature, time reactants molar ratio.Under optimised conditions: 1.5% sodium carbonate (Na 2 CO 3 ) loading, temperature 140°C, 4 hr ratio 3:1 (solketal:ML), high 74.5% 95% purity SoLE was obtained.

Language: Английский

Citations

3
Synthesis of a Pyrrolo[1,2-a]quinazoline-1,5-dione Derivative by Mechanochemical Double Cyclocondensation Cascade DOI Creative Commons

Vanessza Judit Kolcsár,

György Szőllősi

Molecules, Journal Year: 2022, Volume and Issue: 27(17), P. 5671 - 5671

Published: Sept. 2, 2022

N-heterocyclic compounds, such as quinazolinone derivatives, have significant biological activities. Nowadays, the demand for environmentally benign, sustainable processes increases, application of compounds from renewable sources, easily separable heterogeneous catalysts and efficient, alternative activation methods is great importance. In this study, we developed a convenient, green procedure preparation 3a-methyl-2,3,3a,4-tetrahydropyrrolo[1,2-a]quinazoline-1,5-dione through double cyclocondensation cascade using anthranilamide ethyl levulinate. Screening various Brønsted acid showed that Amberlyst® 15 convenient choice. By applying mechanochemical in N-heterotricyclic compound first time, it was possible to shorten necessary time three hours compared 24 h needed under conventional conditions obtain high yield target product.

Language: Английский

Citations

1