ЧЕТВЕРТИЧНЫЕ ПИРИДИНОВЫЕ СОЛИ. СИНТЕЗ, ФИЗИКО-ХИМИЧЕСКИЕ СВОЙСТВА И БИОЛОГИЧЕСКАЯ АКТИВНОСТЬ / QUATERNARY PYRIDINIUM SALTS. SYNTHESIS, PHYSICAL AND CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITY DOI Open Access
Arpine S. Harutyunyan, Elya Safaryan, Tigranuhi Karapetyan

et al.

Bulletin of the Medical Institute after Mehrabyan, Journal Year: 2023, Volume and Issue: unknown, P. 19 - 41

Published: Jan. 1, 2023

Производные пиридиновых солей представляют интерес как с химической, так и фармакологической точки зрения. Обладая высокой биологической активностью, пиридины обеспечивают развитие синтеза новых систем открытие потенциальных лекарств на их основе. В данной работе комплексно представлены основные исследования, проведенные в последние годы по четвертичным солям пиридина, обладающим активностью. // Derivatives of pyridinium salts are interest both from a chemical and pharmacological point view. Having high biological activity, pyridines ensure the development synthesis new heterocyclic systems discovery potential drugs based on them. All this will facilitate transition to salt forms highly active compounds. This work provides brief overview pyridine salts, including synthesis, nucleophilic reactivity, possible ylide-cyclic photochemical reactions, catalysis, as well application spectrum effects ionic liquids (PyILs). The main research conducted in recent years quaternary with activity is comprehensively presented.

One-pot catalyst-free synthesis of benzopyrroxazine derivatives by a mutually activated sequential annulation process DOI
Fuqiang Li,

Pu-Yuan Xie,

Hui‐Yu Chen

et al.

Organic & Biomolecular Chemistry, Journal Year: 2022, Volume and Issue: 20(23), P. 4709 - 4713

Published: Jan. 1, 2022

A one-pot catalyst-free synthetic method of benzopyrroxazine derivatives is reported, which relies on an efficient self-catalyzed [3 + 2] cycloaddition process.

Language: Английский

Citations

1
Regio- and stereoselective synthesis and evaluation of densely functionalized bispiro[oxindole-isoxazole-indandione] hybrids as anticancer agents DOI
Zhi‐Gang Yin, Xiong-Wei Liu, Lin Chen

et al.

New Journal of Chemistry, Journal Year: 2022, Volume and Issue: 46(40), P. 19442 - 19454

Published: Jan. 1, 2022

This is the combination of three key pharmacophores through bispiro quaternary carbon atoms and evaluation their anticancer activity.

Language: Английский

Citations

1
Diastereoselective Dearomatization of Chalcone‐Based Quinolinium Salts to Assemble Bridged Quinobenzazepine Polycycles DOI Open Access

Chengxiang Luo,

Chaoyang Li, Lijie Zhang

et al.

European Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 13, 2023

Abstract Quinobenzazepines are useful in medicinal chemistry, but their synthesis is very challenging. Herein, we designed and synthesized a range of multi‐functional chalcone‐based quinolinium salts; synthetic application the rapid straightforward construction quinobenzazepines was successfully explored. A wide oxa‐bridged quinobenzazepine polycycles were afforded serendipitously through dearomative cascade reaction our newly developed salts acetylacetone. This strategy features high bond‐ ring‐forming efficiency complete regio‐ diastereoselective control.

Language: Английский

Citations

0
ЧЕТВЕРТИЧНЫЕ ПИРИДИНОВЫЕ СОЛИ. СИНТЕЗ, ФИЗИКО-ХИМИЧЕСКИЕ СВОЙСТВА И БИОЛОГИЧЕСКАЯ АКТИВНОСТЬ / QUATERNARY PYRIDINIUM SALTS. SYNTHESIS, PHYSICAL AND CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITY DOI Open Access
Arpine S. Harutyunyan, Elya Safaryan, Tigranuhi Karapetyan

et al.

Bulletin of the Medical Institute after Mehrabyan, Journal Year: 2023, Volume and Issue: unknown, P. 19 - 41

Published: Jan. 1, 2023

Производные пиридиновых солей представляют интерес как с химической, так и фармакологической точки зрения. Обладая высокой биологической активностью, пиридины обеспечивают развитие синтеза новых систем открытие потенциальных лекарств на их основе. В данной работе комплексно представлены основные исследования, проведенные в последние годы по четвертичным солям пиридина, обладающим активностью. // Derivatives of pyridinium salts are interest both from a chemical and pharmacological point view. Having high biological activity, pyridines ensure the development synthesis new heterocyclic systems discovery potential drugs based on them. All this will facilitate transition to salt forms highly active compounds. This work provides brief overview pyridine salts, including synthesis, nucleophilic reactivity, possible ylide-cyclic photochemical reactions, catalysis, as well application spectrum effects ionic liquids (PyILs). The main research conducted in recent years quaternary with activity is comprehensively presented.

Citations

0