Abstract
Electrosynthesis
of
selenylated‐oxazolone
derivatives
via
cascade
selenylation/cyclization
ynamides
was
disclosed.
A
series
diaryl
diselenides,
dialkyl
and
heteroaryl‐substituted
tolerated
in
this
protocol
delivered
4‐selenyloxazolones
28–83%
yields.
The
scale‐up
reaction
the
oxidation
performed
to
showcase
practicability
method.
Furthermore,
mechanistic
experiments
indicated
that
a
cationic
pathway
instead
radical
probably
involved.
Organic & Biomolecular Chemistry,
Journal Year:
2022,
Volume and Issue:
20(18), P. 3798 - 3802
Published: Jan. 1, 2022
A
visible-light-induced
metal-free
cascade
cyclization
of
cyclic
N-sulfonyl
ketimines
with
N-arylglycines
for
the
construction
N-sulfonamide-fused
imidazolidines
was
developed.
The
procedure
employed
3
mol%
eosin
Y
as
photocatalyst
at
room
temperature
under
visible
light
irradiation,
providing
various
in
good
yields
(32
examples,
up
to
86%
yields).
Chemical Communications,
Journal Year:
2022,
Volume and Issue:
58(69), P. 9658 - 9661
Published: Jan. 1, 2022
Herein,
we
describe
a
novel
O2N˙-triggered
ordered
addition
7-endo
cyclization
reaction
with
excellent
chemo-
and
regioselectivity.
With
such
strategy,
structurally
diverse
nitro-benzo[b]azepines
were
prepared
28
examples.
Large-scale
operation
handy
N-Ts
N-Cbz
deprotection
reveal
the
promising
utility
of
this
methodology.
Mechanistic
studies
suggest
that
proceeds
through
radical
pathway.
ACS Organic & Inorganic Au,
Journal Year:
2022,
Volume and Issue:
2(4), P. 306 - 311
Published: March 29, 2022
A
synthetically
beneficial
visible-light-mediated
protocol
has
been
disclosed
to
achieve
C–H
amination
of
readily
available
feedstocks
cyclic
and
acyclic
ethers.
rarely
identified
N-bromosuccinamide–tetrahydrofuran
electron
donor–acceptor
complex
served
as
an
initiator
functionalize
both
α-diazoketones
dialkyl
azodicarboxylates.
This
developed
methodology
gives
alternative
milder
way
construct
the
C–N
bond
can
be
explored
for
formation
C–C
perform
arylation
allylation
reactions.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(17)
Published: March 11, 2024
Abstract
Molecules
containing
ether
skeletons
are
widely
present
in
drugs,
natural
products,
functional
materials,
and
life
science.
Direct
C(sp
3
)−H
bond
functionalization
is
considered
a
powerful
strategy
for
the
construction
of
novel
derivatives.
Photo‐/electro‐chemical
technology
relatively
green
sustainable
synthesis
method,
which
opens
up
broad
application
prospect
field
direct
bonds.
In
recent
years,
photo‐/electro‐mediated
alkylation,
arylation,
alkynylation,
esterification,
mercaptoylation,
sulfidation,
amination
ethers
have
been
extensively
studied.
this
review,
research
progress
compounds
from
2014
to
2023
systematically
reviewed,
scope,
limitations,
mechanisms
some
reactions
discussed.
New Journal of Chemistry,
Journal Year:
2022,
Volume and Issue:
46(19), P. 9451 - 9460
Published: Jan. 1, 2022
A
cascade
annulation
of
N
-phenylpropiolamides
with
diselenides
leading
to
the
construction
3-arylselenenyl
spiro[4.5]trienones
was
realized
under
mild
conditions
Selectfluor
as
sole
oxidant.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(5), P. 2206 - 2206
Published: Feb. 27, 2023
In
this
work,
we
achieved
a
C3-selenylation
of
pyrido[1,2-a]pyrimidin-4-ones
using
an
electrochemically
driven
external
oxidant-free
strategy.
Various
structurally
diverse
seleno-substituted
N-heterocycles
were
obtained
in
moderate
to
excellent
yields.
Through
radical
trapping
experiments,
GC-MS
analysis
and
cyclic
voltammetry
study,
plausible
mechanism
for
selenylation
was
proposed.
Chemical Communications,
Journal Year:
2023,
Volume and Issue:
59(53), P. 8262 - 8265
Published: Jan. 1, 2023
A
palladium-catalyzed
distal
C(sp2)-H
chalcogenation
of
biphenyl
amines
is
described.
This
protocol
demonstrates
scalability,
excellent
chemo-
and
regio-selectivity,
broad
functional
group
tolerance,
providing
efficient
access
to
valuable
aryl
chalcogenides.
Notably,
the
chalcogenated
could
be
further
transformed
8-membered
N,
Se(S)-heterocycles
through
copper-catalyzed
intramolecular
C-N
cyclization.
Chinese Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
42(9), P. 2715 - 2715
Published: Jan. 1, 2022
Fluorinated
compounds
have
been
widely
used
in
pharmaceuticals,
pesticides
and
other
disciplines
due
to
their
special
physical
chemical
properties,
which
motivates
the
frequent
introduction
of
fluorinated
functionalities
into
lead
improve
properties.The
trifluoromethylthio
(SCF3)
group
with
high
electronegativity
lipophilicity
plays
an
important
role
a
multitude
compounds.The
recent
progress
field
cascade
reaction
unsaturated
hydrocarbon
initiated
by
SCF3
radical,
including
design,
mechanism
outlook,
is
summarized.
