Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
137(1)
Published: Sept. 21, 2024
Abstract
Phototheranostics
is
growing
into
a
sparking
frontier
in
disease
treatment.
Developing
single
molecular
species
synchronously
featured
by
powerful
absorption
capacity,
superior
second
near‐infrared
(NIR‐II)
fluorescence
and
prominent
photothermal
conversion
ability
highly
desirable
for
phototheranostics,
yet
remains
formidably
challenging.
In
this
work,
we
propose
design
philosophy
that
the
integration
of
noncovalent
conformational
locks
(NoCLs)
with
aggregation‐induced
emission
(AIE)
formulation
able
to
boost
multiple
photophysical
properties
efficient
phototheranostics.
The
introduction
NoCLs
skeleton
conformation‐locking
feature
center
architecture
indeed
elevates
structural
planarity
rigidity,
which
simultaneously
promotes
capacity
bathochromic‐shifts
wavelength
centered
NIR‐II
region.
Meanwhile,
AIE
tendency
mainly
originated
from
flexibly
propeller‐like
geometry
at
ends
eventually
endows
molecule
satisfactory
intensity
aggregates.
Consequently,
utilizing
optimized
molecule,
unprecedented
performance
on
fluorescence‐photoacoustic‐photothermal
trimodal
imaging‐guided
photothermal‐chemo
synergistic
therapy
demonstrated
precise
tumor
diagnosis
complete
ablation.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Jan. 3, 2024
Abstract
Zinc
metabolism
at
the
cellular
level
is
critical
for
many
biological
processes
in
body.
A
key
observation
disruption
of
homeostasis,
often
coinciding
with
disease
progression.
As
an
essential
factor
maintaining
equilibrium,
zinc
has
been
increasingly
spotlighted
context
development.
Extensive
research
suggests
zinc’s
involvement
promoting
malignancy
and
invasion
cancer
cells,
despite
its
low
tissue
concentration.
This
led
to
a
growing
body
literature
investigating
metabolism,
particularly
functions
transporters
storage
mechanisms
during
transportation
under
control
two
major
transporter
families:
SLC30
(ZnT)
excretion
SLC39
(ZIP)
intake.
Additionally,
this
element
predominantly
mediated
by
metallothioneins
(MTs).
review
consolidates
knowledge
on
signaling
underscores
potential
molecular
pathways
linking
progression,
special
focus
cancer.
We
also
compile
summary
clinical
trials
involving
ions.
Given
main
localization
cell
membrane,
targeted
therapies,
including
small
molecules
monoclonal
antibodies,
offers
promising
avenues
future
exploration.
ChemBioChem,
Journal Year:
2023,
Volume and Issue:
24(18)
Published: June 21, 2023
Abstract
Prodrugs
are
pharmacologically
inactive,
chemically
modified
derivatives
of
active
drugs,
which,
following
in
vivo
administration,
converted
to
the
parent
drugs
through
chemical
or
enzymatic
cleavage.
The
prodrug
approach
holds
tremendous
potential
create
enhanced
version
an
existing
pharmacological
agent
and
leverage
those
improvements
augment
drug
molecules′
bioavailability,
targeting
ability,
therapeutic
efficacy,
safety,
marketability.
Especially
cancer
therapy,
application
has
received
substantial
attention.
A
can
effectively
broaden
window
its
by
enhancing
release
at
targeted
tumor
sites
while
reducing
access
healthy
cells.
spatiotemporally
controlled
be
achieved
manipulating
chemical,
physical,
biological
stimuli
present
site.
critical
strategy
comprises
drug‐carrier
linkages
that
respond
physiological
biochemical
milieu
yield
form.
This
review
will
focus
on
recent
advancements
development
various
fluorophore‐drug
conjugates
widely
used
for
real‐time
monitoring
delivery.
use
different
stimuli‐cleavable
linkers
mechanisms
linker
cleavage
discussed.
Finally,
conclude
with
a
discussion
prospects
challenges
might
impede
future
such
prodrugs.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
64(1)
Published: Sept. 21, 2024
Phototheranostics
is
growing
into
a
sparking
frontier
in
disease
treatment.
Developing
single
molecular
species
synchronously
featured
by
powerful
absorption
capacity,
superior
second
near-infrared
(NIR-II)
fluorescence
and
prominent
photothermal
conversion
ability
highly
desirable
for
phototheranostics,
yet
remains
formidably
challenging.
In
this
work,
we
propose
design
philosophy
that
the
integration
of
noncovalent
conformational
locks
(NoCLs)
with
aggregation-induced
emission
(AIE)
formulation
able
to
boost
multiple
photophysical
properties
efficient
phototheranostics.
The
introduction
NoCLs
skeleton
conformation-locking
feature
center
architecture
indeed
elevates
structural
planarity
rigidity,
which
simultaneously
promotes
capacity
bathochromic-shifts
wavelength
centered
NIR-II
region.
Meanwhile,
AIE
tendency
mainly
originated
from
flexibly
propeller-like
geometry
at
ends
eventually
endows
molecule
satisfactory
intensity
aggregates.
Consequently,
utilizing
optimized
molecule,
unprecedented
performance
on
fluorescence-photoacoustic-photothermal
trimodal
imaging-guided
photothermal-chemo
synergistic
therapy
demonstrated
precise
tumor
diagnosis
complete
ablation.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
14(4)
Published: Nov. 6, 2024
To
address
the
issue
of
nonspecific
biodistribution
a
chemotherapeutic
drug,
stable
[2]pseudorotaxane
complexes
(PK@CAOPP
and
PR@CAOPP)
are
used
to
demonstrate
proof
concept.
Cationic
-PPh3
+
moiety
in
CAOPP
allows
specific
localization
PK@CAOPP/
PR@CAOPP
mitochondrial
membrane
(MM).
Electrostatic
interaction
between
cationic
LysinePK
or
ArgininePR
negatively
charged
phosphoesterCAOPP
functionality
favours
strong
adduct
formation.
The
ALP-induced
hydrolytic
cleavage
phosphoester
cancer
cells
triggers
dephosphorylation
releases
PK/
PR
from
PK@CAOPP/PR@CAOPP.
PK
PR,
derived
Phe-Phe
dipeptide,
formed
fibril-like
molecular
aggregates
MM
induce
dysfunction,
depolarization,
ROS
generation
apoptotic
MCF7
cell
death.
Such
phenomena
were
not
observed
ALP-negative
HEK293
normal
cells.
These
propositions
confirmed
through
control
studies
using
NBDK
PE,
other
guest
molecules.
Smaller
size
inclusion
short
peptides
(PK
PR)
within
hydrophobic
interior
CAOPP,
attributed
their
stability
blood
serum.
Thus,
we
have
demonstrated
use
supramolecular
adducts
as
potential
therapeutic
option
for
treating
without
affecting
healthy
efficacy
was
also
established
with
an
in-vivo
tumour
xenograft
model
Balb/c
nude
mice.
iScience,
Journal Year:
2024,
Volume and Issue:
27(4), P. 109523 - 109523
Published: March 16, 2024
Fabrication
of
stimuli-responsive
superstructure
capable
delivering
chemotherapeutics
directly
to
the
cancer
cell
by
sparing
healthy
cells
is
crucial.
Herein,
we
developed
redox-responsive
hollow
spherical
assemblies
through
self-assembly
disulfide-linked
cysteine-diphenylalanine
(SN).
These
fluorescent
spheres
display
intrinsic
green
fluorescence,
are
proteolytically
stable
and
biocompatible,
allow
for
real-time
monitoring
their
intracellular
entry.
The
disulfide
bond
facilitates
selective
degradation
in
presence
high
glutathione
(GSH)
concentrations,
prevalent
cells.
We
achieved
efficient
encapsulation
(68.72%)
anticancer
drug
doxorubicin
(Dox)
demonstrated
GSH-dependent,
release
within
cancerous
SN-Dox
exhibited
a
20-fold
lower
effective
concentration
(2.5
μM)
compromising
breast
viability
compared
non-malignant
(50
μM).
ability
initiate
DNA
damage
signaling
trigger
apoptosis
was
comparable
that
unencapsulated
drug.
Our
findings
highlight
potential
SN
creating
site-specific
delivery
vehicles
sustained
therapeutic
release.
Advanced Drug Delivery Reviews,
Journal Year:
2023,
Volume and Issue:
204, P. 115138 - 115138
Published: Nov. 18, 2023
Despite
the
enormous
potential
of
nanomedicines
to
shape
future
medicine,
their
clinical
translation
remains
suboptimal.
Translational
challenges
are
present
in
every
step
development
pipeline,
from
a
lack
understanding
patient
heterogeneity
insufficient
insights
on
nanoparticle
properties
and
impact
material-cell
interactions.
Here,
we
discuss
how
adoption
advanced
optical
microscopy
techniques,
such
as
super-resolution
microscopies,
correlative
high-content
modalities,
could
aid
rational
design
nanocarriers,
by
characterizing
cell,
nanomaterial,
interaction
with
unprecedented
spatial
and/or
temporal
detail.
In
this
nanomedicine
arena,
will
implementation
these
versatility
specificity,
can
yield
high
volumes
multi-parametric
data;
machine
learning
rapid
advances
microscopy:
image
acquisition
data
interpretation.
Bioconjugate Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 11, 2025
Over
past
decades,
a
wide
range
of
nanomaterials
have
been
synthesized
and
exploited
to
augment
the
efficacy
biocompatibility
disease
theranostics
nanomedicine.
The
unique
physicochemical
properties
nanomaterials,
such
as
high
specific
surface
area,
tunable
size
shape,
versatile
chemistry,
enable
controlled
modulation
nanomaterial-biosystem
interactions
and,
consequently,
more
precise
interventions,
particularly
at
cellular
level.
selective
nanomaterial-cell
can
be
leveraged
regulate
internalization,
intracellular
trafficking
localization,
clearance
enhance
therapeutic
minimize
potential
cytotoxicity.
Herein,
we
provide
an
overview
our
recent
understanding
journey
modes
action
in
cells.
Specifically,
highlight
various
pathways
trafficking,
excretion
these
nanomaterials.
different
especially
release
delivery,
photothermal
photodynamic
effects,
immunomodulation,
are
also
discussed.
We
conclude
review
by
offering
some
perspectives
on
current
challenges
opportunities
this
field.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
19(17), P. 16248 - 16266
Published: April 28, 2025
Soft
robotics
has
been
rapidly
advancing,
offering
significant
improvements
over
traditional
rigid
robotic
systems
through
the
use
of
compliant
materials
that
enhance
adaptability
and
interaction
with
environment.
However,
current
approaches
face
critical
challenges,
including
reliance
on
complex
"top-down"
fabrication
techniques
difficulty
wireless
powering
control
at
microscale.
Swarm
introduces
a
paradigm
shift,
leveraging
collective
dynamics
to
achieve
cooperative
adaptable
behaviors
among
multiple
units.
Inspired
by
nature,
this
"bottom-up"
approach
enables
swarm
robots
execute
task-specific
reconfigurations,
enhancing
flexibility
robustness.
Field-driven
active
colloids
emerge
as
promising
platform
for
microrobotics,
capable
self-propulsion
self-organization
into
dynamic
patterns
under
external
field
excitation
manipulation.
These
mimic
biologically
inspired
behaviors,
such
flocking
vortex
formation,
providing
versatile
foundation
designing
innovative
microrobots.
This
review
discusses
principles
electric
magnetic
field-driven
self-organization,
focusing
particle
dynamics,
emergence
patterns,
illustrative
examples
functional
It
concludes
future
perspectives
harnessing
these
adaptive,
scalable,
multifunctional
microrobotic
applications.
