Heliyon,
Journal Year:
2024,
Volume and Issue:
10(13), P. e33604 - e33604
Published: June 25, 2024
Perilla
seed
meal
is
an
important
agricultural
by-product
of
perilla
oil
extraction.
The
antioxidant
and
anti-aging
activities
protein
hydrolysate
were
investigated,
the
bioactive
peptides
identified
to
maximize
utilization
resources.
Anti-aging
using
a
combination
peptidomics
in
silico
bioinformatics.
Furthermore,
potential
molecular
mechanism
these
was
explored
through
docking
RT-PCR.
results
showed
significant
properties
F2
(MW
3
kDa
∼5
kDa)
by
inhibition
reactive
oxygen
species
(ROS)
production
β-galactosidase
activity.
Nine
novel
from
subsequently
synthesized
explore
their
bioactivities.
two
peptides,
NFF
PMR,
found
promote
proliferation
keratinocytes
(HaCaT
cells)
suppress
level
ROS
activity
β-galactosidase.
Both
exhibited
strong
binding
affinity
with
Keap1
protein.
Additionally,
PMR
downregulated
expression
matrix
metalloproteinases
(MMPs)
degradation
collagens
(COLs).
underlying
might
involve
competitive
facilitate
release
Nrf2
activation
NF-κB
signal
pathway.
This
study
provides
theoretical
basis
for
application
functional
cosmetics
presents
perspective
investigation
additional
food-derived
peptides.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(20), P. 7165 - 7165
Published: Oct. 19, 2023
Peptides
are
at
the
cutting
edge
of
contemporary
research
for
new
potent,
selective,
and
safe
therapeutical
agents.
Their
rise
has
reshaped
pharmaceutical
landscape,
providing
solutions
to
challenges
that
traditional
small
molecules
often
cannot
address.
A
wide
variety
natural
modified
peptides
have
been
obtained
studied,
many
others
advancing
in
clinical
trials,
covering
multiple
therapeutic
areas.
As
demand
peptide-based
therapies
grows,
so
does
need
sustainable
environmentally
friendly
synthesis
methods.
Traditional
peptide
synthesis,
while
effective,
involves
draining
processes,
generating
significant
waste
consuming
vast
resources.
The
integration
green
chemistry
offers
alternatives,
prioritizing
eco-friendly
reduction,
energy
conservation.
This
review
delves
into
transformative
potential
applying
principles
by
discussing
relevant
examples
application
such
approaches
production
active
ingredients
(APIs)
with
a
structure
how
these
efforts
critical
an
effective
transition
era
field.
Chemical Reviews,
Journal Year:
2022,
Volume and Issue:
122(16), P. 13516 - 13546
Published: July 11, 2022
Since
the
last
century,
peptides
have
gained
wide
acceptance
as
drugs,
with
almost
100
already
in
market
and
a
large
number
pipeline.
In
this
context,
peptide
synthesis
has
grown
massively
stringent
field
for
pharmaceuticals
around
globe.
Three
methodologies,
namely,
classical
solution
(CSPS),
solid-phase
(SPPS),
liquid-phase
(LPPS),
made
significant
contributions
to
field.
This
review
provides
comprehensive
integrated
vision
of
LPPS
third
wave
synthesis.
combines
advantages
CSPS
SPPS,
where
elongation
is
carried
out
growing
chain
supported
on
soluble
tag,
which
confers
characteristic
properties.
protocols
allow
large-scale
production
reduce
use
excess
reagents
solvents,
thus
meeting
principles
green
chemistry.
review,
tags
associated
are
broadly
discussed
under
following
headings:
polydisperse
polyethylene
glycol
(PEG),
membrane-enhanced
(MEPS),
fluorous
technology,
ionic
liquids
(ILs),
PolyCarbon,
hydrophobic
polymers,
group-assisted
purification
(GAP).
It
also
highlights
signature
accomplishments
limitations
same.
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(7), P. 996 - 996
Published: July 12, 2023
Cyclic
peptides
are
molecules
that
already
used
as
drugs
in
therapies
approved
for
various
pharmacological
activities,
example,
antibiotics,
antifungals,
anticancer,
and
immunosuppressants.
Interest
these
has
been
growing
due
to
the
improved
pharmacokinetic
pharmacodynamic
properties
of
cyclic
structure
over
linear
by
evolution
chemical
synthesis,
computational,
vitro
methods.
To
date,
53
have
different
regulatory
authorities,
many
others
clinical
trials
a
wide
diversity
conditions.
In
this
review,
potential
is
presented,
general
aspects
their
synthesis
development
discussed.
Furthermore,
an
overview
also
given,
summarized.
World Journal of Advanced Research and Reviews,
Journal Year:
2024,
Volume and Issue:
21(3), P. 010 - 018
Published: March 3, 2024
In
the
realm
of
electronics
manufacturing,
management
chemicals
is
paramount
to
safeguarding
both
worker
health
and
environmental
sustainability.
This
review
delves
into
strategies
challenges
associated
with
chemical
within
this
industry.
The
utilization
various
in
manufacturing
processes
presents
potential
hazards
workers
environment.
From
cleaning
agents
solvents
fluxes,
these
substances
pose
risks
ranging
from
acute
toxicity
long-term
effects
contamination.
Effective
are
therefore
indispensable.
discusses
proactive
measures
implemented
by
manufacturers
mitigate
risks.
It
explores
adoption
alternative,
less
hazardous
implementation
engineering
controls
minimize
exposure.
Additionally,
stringent
protocols
for
handling,
storage,
disposal
essential
components
comprehensive
programs.
Furthermore,
regulatory
frameworks
play
a
pivotal
role
shaping
practices
sector.
Compliance
local
international
regulations
such
as
REACH
(Registration,
Evaluation,
Authorization,
Restriction
Chemicals)
RoHS
(Restriction
Hazardous
Substances)
imperative
ensure
safety
However,
despite
efforts,
persist.
Balancing
need
innovation
productivity
requirements
remains
significant
challenge
manufacturers.
global
supply
chain
complexities
add
another
layer
complexity
efforts.
demands
multi-faceted
approach
encompassing
technological
innovation,
compliance,
commitment
stewardship.
By
addressing
collaboratively,
industry
can
strive
towards
safer
more
sustainable
practices.
Marine Drugs,
Journal Year:
2022,
Volume and Issue:
20(6), P. 397 - 397
Published: June 15, 2022
Oceans
are
a
rich
source
of
structurally
unique
bioactive
compounds
from
the
perspective
potential
therapeutic
agents.
Marine
peptides
particularly
interesting
group
secondary
metabolites
because
their
chemistry
and
wide
range
biological
activities.
Among
them,
cyclic
exhibit
broad
spectrum
antimicrobial
activities,
including
against
bacteria,
protozoa,
fungi,
viruses.
Moreover,
there
several
examples
marine
revealing
activities
numerous
drug-resistant
bacteria
making
these
very
promising
resource
in
search
for
novel
agents
to
revert
multidrug-resistance.
This
review
summarizes
174
with
antibacterial,
antifungal,
antiparasitic,
or
antiviral
properties.
These
natural
products
were
categorized
according
sources—sponges,
mollusks,
crustaceans,
crabs,
fungi—and
chemical
structure—cyclic
depsipeptides.
The
microorganisms,
unusual
structural
characteristics,
hits
more
advanced
(pre)clinical
studies,
highlighted.
Nocathiacins
I–III
(91–93),
unnarmicins
A
(114)
C
(115),
sclerotides
(160)
B
(161),
plitidepsin
(174)
can
be
highlighted
considering
not
only
high
potency
vitro,
but
also
vivo
results.
models
molecular
modifications
and/or
total
synthesis
obtain
potent
compounds,
improved
properties
higher
quantity.
Solid-phase
Fmoc-
Boc-protection
is
major
synthetic
strategy
properties,
key
presented
guiding
microbiologist
medicinal
chemists
discovery
new
drug
candidates
sources.
Current Pharmaceutical Design,
Journal Year:
2023,
Volume and Issue:
29(9), P. 652 - 674
Published: Feb. 2, 2023
Bioactive
peptides
are
specific
protein
fragments
that
prove
health-promoting
potential
for
humans.
The
bioactivities
include
antimicrobial,
antioxidant,
anticancer,
immunomodulatory
activities,
etc.
Hence,
bioactive
peptides'
production
technology
and
processes
have
attracted
excessive
attention,
especially
concerning
synthesis,
separation,
identification,
functionality.
This
review
summarizes
the
relevant
investigations
from
above
four
aspects.
Among
of
peptides,
biosynthesis,
chemosynthesis,
separation
purification,
interactions
responsible
peptide-based
nanostructures
emphasized.
Here,
biosynthesis
includes
enzymatic
hydrolysis,
microbial
fermentation,
recombinant
DNA
technology,
chemosynthesis
consists
solution-phase
peptide
synthesis
solid-phase
(SPPS).
commonly
used
enzymes
in
hydrolysis
investigated,
including
pepsin,
trypsin,
alcalase.
microorganisms,
typical
processes,
sources,
advantages
fermentation
analyzed.
Membrane
(including
ultrafiltration
nanofiltration),
chromatography
ion-exchange
chromatography,
gel
filtration
affinity
reverse-phase
high-performance
liquid
(RP-HPLC)),
electrophoresis
detailed
purification
technology.
Mass
spectrometry
(MS),
its
combination
with
method,
nuclear
magnetic
resonance
(NMR)
elucidated
identification
non-covalent
involve
electrostatic
force,
hydrogen
bonds,
π-π
stacking,
hydrophobic
interaction,
van
der
Waals
force.
Afterward,
we
detail
antihypertensive,
antithrombotic,
activities.
activity
analysis
mainly
involves
structural
features,
mechanisms
action,
influencing
factors.
Based
on
functionality
elucidation,
challenges
application
biomedicine
given.
challenge
is
analyzed
aspects
technologies
factors
bioactivities.
Our
work
will
elaborate
advances
their
bioactivities,
which
could
promote
expand
industrial
applications.
Journal of Peptide Science,
Journal Year:
2024,
Volume and Issue:
30(9)
Published: April 25, 2024
On
December
12th,
2023,
the
European
Commission
took
regulatory
action
to
amend
Annex
XVII
of
REACH,
imposing
restrictions
on
use
N
,
‐dimethylformamide
(DMF)
within
EU
market
owing
its
high
toxicity.
Historically,
DMF
has
been
widely
considered
gold
standard
for
solid‐phase
peptide
synthesis
(SPPS).
Being
urgent
propose
alternative
solvents,
we
tested
suitability
non‐hazardous
neat
and
mixed
solvents.
Notably,
binary
solvent
mixtures
containing
dimethyl
sulfoxide
as
one
partners
demonstrated
efficacy
in
solubilizing
reagents
while
maintaining
desired
swelling
characteristics
common
resins.
A
series
were
automated
SPPS,
both
at
room
temperature
temperature,
employing
PurePep®
Chorus
synthesizer,
which
enabled
controlled
induction
heating
between
25
90°C
with
oscillation
mixing.
The
performances
assessed
challenging
sequences,
i.e.,
ACP
(65–74),
longer
aggregating
sequences
like
SARS‐CoV‐2
RBM
(436–507)
β‐amyloid
(1–42).
Furthermore,
part
proposed
sustainable
approach
minimize
utilization
hazardous
coupled
novel
PurePep
EasyClean
catch‐and‐release
purification
technology.
This
work,
addressing
compliance,
emphasizes
crucial
role
green
chemistry
advancing
safer
more
environmentally
friendly
practices
SPPS.
