Magnesium-Titanium Alloys: A Promising Solution for Biodegradable Biomedical Implants

Materials, Journal Year: 2024, Volume and Issue: 17(21), P. 5157 - 5157

Published: Oct. 23, 2024

Magnesium (Mg) has attracted considerable attention as a biodegradable material for medical implants owing to its excellent biocompatibility, mitigating long-term toxicity and stress shielding. Nevertheless, challenges arise from rapid degradation low corrosion resistance under physiological conditions. To overcome these challenges, titanium (biocompatibility resistance) been integrated into Mg. The incorporation of significantly improves mechanical properties, thereby enhancing performance in biological settings. Mg–Ti alloys are produced through alloying spark plasma sintering (SPS). SPS technique transforms powder mixtures bulk materials while preserving structural integrity, resulting enhanced resistance, particularly Mg80-Ti20 alloy simulated body fluids. Moreover, revealed no more when assessed on pre-osteoblastic cells. Furthermore, the ability Mg–Ti-based create composites with polymers such PLGA (polylactic-co-glycolic acid) widen their biomedical applications by regulating ensuring pH stability. These promote temporary orthopaedic implants, offering initial load-bearing capacity during healing process fractures without requiring second surgery removal. address scalability constraints, further research is necessary investigate additional consolidation methods beyond SPS. It essential evaluate relationship between loading confirm adequacy environments. This review article highlights importance characterization evaluation alloys, reinforcing applicability fracture fixation various implants.

Language: Английский

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Biomimetic Implant Surfaces and Their Role in Biological Integration—A Concise Review

Biomimetics, Journal Year: 2022, Volume and Issue: 7(2), P. 74 - 74

Published: June 6, 2022

Background: The increased use of dental implants in oral rehabilitation has been followed by the development new biomaterials as well improvements performance already use. This triggers need for appropriate analytical approaches to assess biological and, ultimately, clinical benefits these approaches. Aims: To address role physical, chemical, mechanical, and characteristics order determine critical parameters improve responses long-term effectiveness implant surfaces. Data sources methods: Web Science, MEDLINE Lilacs databases were searched last 30 years English, Spanish Portuguese idioms. Results: Chemical composition, wettability, roughness, topography surfaces have all linked regulation cell interactions, osseointegration, bone tissue peri-implant mucosa preservation. Conclusion: Techniques involving subtractive additive methods, especially those laser treatment or embedding bioactive nanoparticles, demonstrated promising results. However, literature is heterogeneous regarding study design methodology, which limits comparisons between studies definition determinants optimal response.

Language: Английский

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Development of bioactive and antimicrobial nano-topography over selective laser melted Ti6Al4V implant and its in-vitro corrosion behavior

Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials, Journal Year: 2023, Volume and Issue: 149, P. 106210 - 106210

Published: Oct. 26, 2023

Language: Английский

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Optimizing Osseointegration in Dental Implantology: A Cross-Disciplinary Review of Current and Emerging Strategies

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 30, 2023

The paper explores the correlation between osteointegration and dental implant stability, investigating relationship its implications for successful outcomes in dentistry. Osteointegration, defined as direct structural functional connection living bone surface, plays a crucial role determining stability long-term success of implants. This review synthesizes current knowledge from scientific literature clinical studies to elucidate factors influencing their impact on stability. Surface characteristics implants, such topography chemistry, well surgical techniques employed during placement, are examined detail, emphasizing significant influence osseointegration subsequent Additionally, host-related quality, systemic conditions, patient-specific considerations explored further comprehend complexity process. abstract underscores importance achieving an optimal bone-implant interface ensure integration Furthermore, emerging technologies materials, computer-guided placement biomimetic surfaces, discussed potential enhance improve

Language: Английский

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Unveiling the pH influence: Enhancing hydroxyapatite-coated titanium biomedical implants through electrochemical deposition

Ceramics International, Journal Year: 2024, Volume and Issue: 50(8), P. 13412 - 13421

Published: Jan. 23, 2024

Language: Английский

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Osteointegration of Ti Bone Implants: A Study on How Surface Parameters Control the Foreign Body Response

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(8), P. 4662 - 4681

Published: July 30, 2024

The integration of titanium (Ti)-based implants with bone is limited, resulting in implant failure. This lack osteointegration due to the foreign body response (FBR) that occurs after implantation biodevices. process begins protein adsorption, which governed by surface properties, e.g., chemistry, charge, wettability, and/or topography. distribution and composition layer turn influence recruitment, differentiation, modulation immune cells. subsequent events occur at bone–material interface will ultimately determine whether encapsulated or integrate bone. Despite numerous studies evaluating properties various stages FBR, factors affect tissue–material interactions are often studied isolation small correlations technical challenges involved assessing them vitro vivo. Consequently, conformation on Ti design remains an unresolved research question. objective this review comprehensively evaluate existing literature effect parameters its alloys a particular focus adsorption osteoimmunomodulation. evaluation aims systematically describe these effects formation.

Language: Английский

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Strategies for Improving Impaired Osseointegration in Compromised Animal Models

Journal of Dental Research, Journal Year: 2024, Volume and Issue: 103(5), P. 467 - 476

Published: April 15, 2024

Implant osseointegration is reduced in patients with systemic conditions that compromise bone quality, such as osteoporosis, disuse syndrome, and type 2 diabetes. Studies using rodent models designed to mimic these compromised demonstrated bone-to-implant contact (BIC) or a decline mineral density. These adverse effects are consequence of disrupted intercellular communication. A variety approaches have been developed compensate for the altered microenvironment inherent conditions, including use biologics implant surface modification. Chemical physical modification properties at microscale, mesoscale, nanoscale levels closely resemble topography osteoclast resorption pits found has proven be highly effective strategy improving osseointegration. The addition hydrophilicity further enhances osteoblast response bone-implant interface. modifications, applied either alone combination, improve by increasing proliferation osteoblastic differentiation osteoprogenitor cells enhancing angiogenesis while modulating activity achieve net new formation, although specific vary treatment. In direct on surface-attached cells, communication between marrow stromal immunomodulatory sensitive properties. This article reports advances titanium combination novel therapeutics animal human disease affecting quality. It offers clinically translatable perspectives clinicians consider when different strategies long-term performance patients. review supports bioactive coatings, localized pragmatic BIC enhance osteogenic from both structural molecular standpoints.

Language: Английский

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Biomaterials for cardiovascular diseases

Biomedical Technology, Journal Year: 2024, Volume and Issue: 7, P. 1 - 14

Published: June 5, 2024

Cardiovascular disease (CVD) remains a leading cause of mortality worldwide, claiming countless lives and posing formidable health challenge. Extensive efforts have been dedicated to combating this disease, including the development innovative biomaterials for blood vessel stents, drug delivery imaging diagnosis. These advancements substantially addressed issues such as patient rejection contamination. In review, we begin by outlining prevalence various forms CVD. Subsequently, delve into advanced biomaterials—including synthetic biomaterials, natural hybrid biomaterials—and medical instruments used in treatment or alleviation CVD, discussing their advantages limitations. Finally, offer insights future prospects strategies refining these technologies moving forward.

Language: Английский

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Electrospray deposited plant-based polymer nanocomposite coatings with enhanced antibacterial activity for Ti-6Al-4V implants

Progress in Organic Coatings, Journal Year: 2023, Volume and Issue: 186, P. 107965 - 107965

Published: Sept. 20, 2023

Language: Английский

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A novel nanosecond pulsed laser textured moat configurations for enhancing surface wettability, corrosion and tribology behaviour of Ti6Al4V implant material

Materials Today Communications, Journal Year: 2024, Volume and Issue: 39, P. 108701 - 108701

Published: March 22, 2024

Language: Английский

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