Synthetic Communications,
Journal Year:
2022,
Volume and Issue:
52(9-10), P. 1209 - 1244
Published: April 5, 2022
Imidazo[1,2-a]pyridines
are
privileged
aza-fused
heterocyclic
scaffolds
possessing
wide
range
of
applications
in
medicinal
chemistry,
organometallics
and
material
science.
functionalized
with
aroyl
group
perceived
for
their
therapeutic
applications.
However,
inaccessibility
this
aroylated
imidazo[1,2-a]pyridine
by
Friedel-Crafts
reaction
had
left
chemists
an
alternate
three-steps
long
tiresome
protocol
as
the
only
source.
Hence,
review
we
have
discussed
all
rigorous
efforts
made
last
decade
regioselective
straightforward
synthesis
3-aroyl
2-aroyl
imidazo[1,2-a]pyridines
from
readily
accessible
precursors
step-economic
pathway.
Most
importantly,
it
draws
our
attention
towards
challenge
aroylation
at
C-2
position
imidazo[1,2-a]pyridines,
three
methods
reported
till
date.
Advanced Synthesis & Catalysis,
Journal Year:
2021,
Volume and Issue:
363(22), P. 5047 - 5071
Published: Oct. 1, 2021
Abstract
Electrochemical
synthesis
offers
a
mild,
simple,
and
efficient
tool
for
the
preparation
of
interesting
useful
molecules,
thus
eluding
severe
chemical
oxidizing
reducing
agents
used
in
conventional
synthetic
methods.
In
particular,
electrochemical
C−H
activation
is
expected
to
play
an
important
role
direct
functionalization
heterocyclic
compounds.
Over
past
few
decades,
research
interest
imidazopyridine
indazole
has
increased
significantly
due
their
multipurpose
uses
medicinal
industrial
chemistry.
Therefore,
structural
modification
these
heterocycles
using
electro‐oxidation
become
one
topics
among
organic
chemistry
recent
time.
This
review
provides
comprehensive
discussion
indazoles
imidazopyridines
published
so
far.
A
summary
current
challenges
future
direction
development
green
methods
also
presented.
magnified
image
Green Synthesis and Catalysis,
Journal Year:
2022,
Volume and Issue:
3(3), P. 227 - 242
Published: March 19, 2022
Imidazo[1,2-a]pyridines
are
unique
nitrogen-containing
organic
compounds
with
wide
applications
in
pharmaceuticals,
natural
products,
material
science
and
organometallics.
Due
to
their
significant
biological
synthetic
value,
the
construction
of
imidazo[1,2-a]pyridine
scaffolds
has
been
a
highly
intriguing
research
topic,
substantial
progress
had
made
past
decades.
In
this
review,
we
aim
summarize
current
advances
direct
C–H
functionalization
imidazo[1,2-a]pyridines
under
transition-metal-free
conditions.
For
selected
examples,
focused
on
design
catalytic
cycle
mechanism,
as
well
representative
outcomes
applications.
Organic & Biomolecular Chemistry,
Journal Year:
2023,
Volume and Issue:
21(36), P. 7267 - 7289
Published: Jan. 1, 2023
Herein
we
disclose
the
synthesis
and
an
overview
of
all
functionalization
reactions
at
each
carbon
atom,
viz
,
C2,
C3,
C5,
C6,
C7
C8
imidazo[1,2-
a
]pyridine.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(7), P. 4840 - 4850
Published: March 19, 2024
Here,
we
report
controlled
and
site-selective
C–H
alkenylation
dialkenylation
of
indolizines
pyrrolo[1,2-a]quinolines
with
β-alkoxyvinyl
trifluoromethylketones
under
simple
practical
conditions.
Moreover,
this
direct
strategy
can
also
be
extended
to
imidazo[1,2-a]pyridines.
Notably,
without
a
transition
metal
external
oxidant,
efficient
dehydrogenative
β-alkenylation
tertiary
amines
is
presented.
Chinese Journal of Chemistry,
Journal Year:
2021,
Volume and Issue:
40(1), P. 97 - 103
Published: Oct. 5, 2021
Comprehensive
Summary
An
efficient
and
eco‐friendly
carbon
nitride
nanosheet
(NM‐g‐C
3
N
4
)‐catalyzed
decarboxylative
coupling
reaction
of
imidazo‐fused
heterocycles
(
i.e
.,
imidazo[1,2‐
a
]pyridines,
benzo[
d
]imidazo[2,1‐
b
]thiazole)
with
‐phenylglycines
in
dimethyl
carbonate
(DMC)
has
been
developed.
The
toxic
solvents,
external
oxidants,
restricted
conditions
could
be
effectively
avoided
this
powerful
sustainable
protocol.
Remarkably,
NM‐g‐C
straightforwardly
recovered
by
simple
centrifugation
recycled
reused
at
least
7
times
without
an
obvious
decrease
catalytic
activity.
The Journal of Organic Chemistry,
Journal Year:
2021,
Volume and Issue:
86(22), P. 15973 - 15991
Published: June 29, 2021
Oxidation
potential-guided
electrochemical
radical–radical
cross-coupling
reactions
between
N-heteroarenes
and
sodium
sulfinates
have
been
established.
Thus,
simple
cyclic
voltammetry
measurement
of
substrates
predicts
the
likelihood
successful
coupling
reactions,
allowing
direct
synthetic
access
to
3-sulfonylated
imidazopyridines
indolizines.
The
developed
sulfonylated
boast
green
nature
that
are
oxidant-
metal-free.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(11), P. 3461 - 3461
Published: May 27, 2022
Imidazopyridines
constitute
one
of
the
most
important
scaffolds
in
medicinal
chemistry,
as
their
skeleton
could
be
found
a
myriad
biologically
active
molecules.
Although
numerous
strategies
were
elaborated
for
imidazopyridine
preparation
2010s,
novel
eco-compatible
synthetic
approaches
have
emerged,
conscious
climate
change
concerns.
In
this
framework,
photochemical
methods
been
promoted
to
conceive
heterocyclic
motif
over
last
decade.
This
review
covers
recently
published
works
on
synthesizing
highly
functionalized
imidazopyridines
by
light
induction.
