Multi-Hydroxyl POSS Supported Iridium Complexes as a Recyclable Catalyst for Selective Synthesis of N-/C-Substituted Indoles and the Total Synthesis of HIV-1 Fusion Inhibitor DOI
Jiahao Li, Li Chen, Likui Wang

et al.

Published: Jan. 1, 2023

A novel pyridyl-thiadiazole ligand has been designed, synthesized, and employed in the preparation of a heterogeneous iridium catalyst supported on multi-hydroxyl polyhedral oligomeric silsesquioxane. The as-prepared exhibits excellent catalytic activity one-pot cascade selective synthesis N-/C-substituted indole derivatives from amino alcohols via borrowing hydrogen strategy. Meanwhile, it was observed that this approach good functional group tolerance broad substrate scope. Notably, by employing system, an inhibitor against gp41-mediated HIV-1 fusion core structure could be conveniently synthesized 2-aminophenethyl alcohol benzyl 40.6% total yield for only four steps “borrowing hydrogen” Mechanistic explorations showed transformation undergoes processes, involving N/C-alkylation through strategy, oxidative cyclization. Recycling experiments disclosed easily recovered reused at least seven times with TON.

Language: Английский

SmI2‐mediated C‐alkylation of Ketones with Alcohols under Microwave Conditions: A Novel Route to Alkylated Ketones DOI

Gaurav Pawar,

Shaik Mahammad Ghouse, Swayamsiddha Kar

et al.

Chemistry - An Asian Journal, Journal Year: 2022, Volume and Issue: 17(8)

Published: Feb. 22, 2022

A novel protocol is developed towards the preparation of alkylated ketones from alcohols in presence catalytic amount SmI2 and base with elimination water as a single by-product under microwave irradiation conditions. Furthermore, applicability this methodology to synthesis Donepezil late-stage functionalization Pregnenolone also reported. Successful application Friedländer quinolone using 2-aminobenzyl alcohol various acetophenones expand synthetic utility protocol.

Language: Английский

Citations

6
Hydrosilylative reduction of secondary amides to amines catalyzed by geometry-constrained NNN-cobalt complexes DOI
Shuting Dong,

Zhijian Zong,

Nan Sun

et al.

New Journal of Chemistry, Journal Year: 2023, Volume and Issue: 47(12), P. 5603 - 5610

Published: Jan. 1, 2023

An efficient Co-catalyzed hydrosilylative reduction of secondary amides to amines was achieved utilizing an N , -donor-coordinated cobalt complex as the precatalyst.

Language: Английский

Citations

3
Molecular Iodine‐Catalysed Reductive Alkylation of Indoles: Late‐Stage Diversification for Bioactive Molecules DOI

Xionglve Cheng,

Lili Wang,

Yide Liu

et al.

European Journal of Organic Chemistry, Journal Year: 2022, Volume and Issue: 2022(34)

Published: May 16, 2022

Abstract Herein, we report a molecular iodine‐catalysed reductive alkylation of indoles with carbonyl compounds using Et 3 SiH for the efficient synthesis C3‐alkylated indoles. This metal‐free and environmental‐friendly process exhibits excellent functional group tolerance, mild conditions, wide substrate scope. Notably, synthetic usefulness this strategy to pharmacochemistry was highlighted by late‐stage modification drug‐like molecules.

Language: Английский

Citations

5
Porous Cross-Linked Polymer PPBI@Mn Catalyzed the Selective Synthesis of Bisindolylmethane Derivatives DOI
Kai Zhang, Haiyan Zhu, Dawei Wang

et al.

Catalysis Letters, Journal Year: 2024, Volume and Issue: 154(10), P. 5669 - 5682

Published: July 2, 2024

Language: Английский

Citations

0
Multi-Hydroxyl POSS Supported Iridium Complexes as a Recyclable Catalyst for Selective Synthesis of N-/C-Substituted Indoles and the Total Synthesis of HIV-1 Fusion Inhibitor DOI
Jiahao Li, Li Chen, Likui Wang

et al.

Published: Jan. 1, 2023

A novel pyridyl-thiadiazole ligand has been designed, synthesized, and employed in the preparation of a heterogeneous iridium catalyst supported on multi-hydroxyl polyhedral oligomeric silsesquioxane. The as-prepared exhibits excellent catalytic activity one-pot cascade selective synthesis N-/C-substituted indole derivatives from amino alcohols via borrowing hydrogen strategy. Meanwhile, it was observed that this approach good functional group tolerance broad substrate scope. Notably, by employing system, an inhibitor against gp41-mediated HIV-1 fusion core structure could be conveniently synthesized 2-aminophenethyl alcohol benzyl 40.6% total yield for only four steps “borrowing hydrogen” Mechanistic explorations showed transformation undergoes processes, involving N/C-alkylation through strategy, oxidative cyclization. Recycling experiments disclosed easily recovered reused at least seven times with TON.

Language: Английский

Citations

0